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In vitro apatite forming ability of type I collagen hydrogels containing bioactive glass and silica sol-gel particles

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Abstract

Type I collagen hydrogel containing bioactive glass (CaO-P2O5-SiO2) and silica sol-gel micrometric particles were prepared and their in vitroapatite-forming ability in simulated body fluid assessed. X-ray diffraction and scanning electron microscopy analysis showed that bioactive glass particles entrapment in collagen matrix did not inhibit calcium phosphate formation and induced morphology variations on the crystalline phase precipitated on the hydrogel surface. The silica—collagen hydrogel composite precipitated calcium phosphate whereas silica particles and collagen hydrogel alone did not, indicating a possible synergetic effect between collagen and silica on the apatite-forming ability. Mechanisms of calcium phosphate precipitation and its relevance to biomaterial development are discussed.

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  1. Laboratoire de Chimie de la Matière Condensée, CNRS-UMR 7574, Université Pierre et Marie Curie, 4, Place Jussieu, F-75252, Paris, cedex 05, France

    David Eglin, Sonia Maalheem, Jacques Livage & Thibaud Coradin

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  1. David Eglin
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  2. Sonia Maalheem
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  3. Jacques Livage
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  4. Thibaud Coradin
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Correspondence to Thibaud Coradin.

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Eglin, D., Maalheem, S., Livage, J. et al. In vitro apatite forming ability of type I collagen hydrogels containing bioactive glass and silica sol-gel particles. J Mater Sci: Mater Med 17, 161–167 (2006). https://doi.org/10.1007/s10856-006-6820-6

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  • DOI: https://doi.org/10.1007/s10856-006-6820-6

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