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Mechanochemical synthesis and in vitro studies of chitosan-coated InAs/ZnS mixed nanocrystals

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Abstract

In this paper, InAs/ZnS mixed nanocrystals were synthesized by dry high-energy milling approach in the first step. The obtained nanocrystals were characterized from structural point of view by X-ray diffraction analysis and Raman spectroscopy, and from the morphological point of view by scanning electron microscopy. In the next step, the nanocrystals were subjected to wet ultra-fine milling in order to obtain a nanosuspension of chitosan-coated InAs/ZnS nanocrystals with bio-imaging properties. The stability of the nanosuspension was examined by zeta potential and particle size distribution measurements. The prepared nanosuspension was stable with high values of zeta potential. Its optical properties were also studied using UV–Vis and PL spectroscopies. The determined fluorescent properties confirming the potential in bio-imaging applications were verified on cancer cell lines Caco-2, HCT116, HeLa, and MCF7.

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Acknowledgements

This work was supported by the Slovak Research and Development Agency under the contract No. APVV-14-0103 and by the Slovak Grant Agency VEGA (project 2/0027/14).

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Authors and Affiliations

  1. Institute of Geotechnics, Slovak Academy of Sciences, Watsonova 45, 04001, Košice, Slovakia

    Zdenka Bujňáková, Erika Dutková, Anna Zorkovská, Matej Baláž, Jaroslav Briančin & Peter Baláž

  2. Institute of Electronics and Photonics, Slovak University of Technology, Ilkovičova 3, 81219, Bratislava, Slovakia

    Jaroslav Kováč Jr.

  3. Faculty of Medicine, P. J. Šafárik University, 04011, Košice, Slovakia

    Martin Kello & Ján Mojžiš

Authors
  1. Zdenka Bujňáková
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  2. Erika Dutková
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  3. Anna Zorkovská
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Correspondence to Zdenka Bujňáková.

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Bujňáková, Z., Dutková, E., Zorkovská, A. et al. Mechanochemical synthesis and in vitro studies of chitosan-coated InAs/ZnS mixed nanocrystals. J Mater Sci 52, 721–735 (2017). https://doi.org/10.1007/s10853-016-0366-x

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  • DOI: https://doi.org/10.1007/s10853-016-0366-x

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