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Novel antibacterial electrospun mats based on poly(d,l-lactide) nanofibers and zinc oxide nanoparticles

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Abstract

This investigation addresses the morphological, mechanical, and antibacterial evaluation of nanocomposite mats based on poly(d,l-lactide) nanofibers with different zinc oxide nanoparticles (nano-ZnO) concentration, that were elaborated by two techniques, i.e., electrospinning of polymer/ZnO solutions and the combination of electrospinning of polymer solutions with electrospraying of nano-ZnO dispersions. The analysis of the precursory solutions was carried out in order to understand the achieved morphology of nanofibers. The obtained poly(d,l-lactide)/ZnO fibrous mats showed a uniform morphology with an average porosity ca. 55 % and average pore size around 45 μm. The presence of ZnO nanoparticles increased the toughness of the mats, and an optimal nano-ZnO concentration (i.e., 3 wt%) was observed at which the tensile strength and Young’s modulus could be improved. Concerning to the antibacterial properties, a relatively low concentration of nanoparticles provoked a growth inhibition of the Gram-negative Escherichia coli and the Gram-positive Staphylococcus aureus bacteria. The mats have potential features for use as antimicrobial wound dressings.

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Acknowledgements

The authors thank CONACyT (México) for providing H. Rodríguez-Tobías with a Ph.D. Grant as well as a financial support for the research stay in the ICMPE (Thiais, France). The authors also thank Jesús Cepeda, Myriam Lozano, María Luisa López (CIQA, México), and Marie-France Trichet (ICMPE, France) for their technical assistance in issues related to electron microscopy characterization, as well as Enrique Jiménez and Arely Velazquez (CIQA, México) for the facilities concerning viscosity measurements, and finally Jesús Quiróz and Gabriela Padrón (CIQA, México) for their technical support in the evaluation of the mechanical and antibacterial properties, respectively.

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Authors and Affiliations

  1. Centro de Investigación en Química Aplicada, Blvd. Enrique Reyna No. 140, C.P. 25294, Saltillo, COAH, Mexico

    Heriberto Rodríguez-Tobías, Graciela Morales, Antonio Ledezma & Jorge Romero

  2. Institut de Chimie et des Matériaux Paris-Est, UMR 7182 CNRS-Université Paris-Est Créteil, 2, rue Henri Dunant, 94320, Thiais, France

    Daniel Grande

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  1. Heriberto Rodríguez-Tobías
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  2. Graciela Morales
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Correspondence to Graciela Morales.

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Rodríguez-Tobías, H., Morales, G., Ledezma, A. et al. Novel antibacterial electrospun mats based on poly(d,l-lactide) nanofibers and zinc oxide nanoparticles. J Mater Sci 49, 8373–8385 (2014). https://doi.org/10.1007/s10853-014-8547-y

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  • DOI: https://doi.org/10.1007/s10853-014-8547-y

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