Abstract
Purpose
Magnetic resonance imaging (MRI) with late gadolinium enhancement is commonly performed in patients with non-ischemic LV ventricular tachycardia/ventricular premature depolarizations (non-ischemic LV-VT/VPDs) to define VT substrate prior to catheter ablation. We investigated the prevalence of abnormal voltage and VT localized to areas of the myocardium not reported to have late gadolinium enhancement (LGE) on routine pre-procedural MRI and sought to determine if quantitative MRI analysis could reduce this discordance.
Methods
Patients with non-ischemic LV-VT/VPD who underwent LV endocardial mapping with VT/VPD ablation and either septal or free wall MRI-voltage discordance were studied. Electroanatomic maps were analyzed post-procedure for areas of electrogram-defined scar and VT localized to areas without reported LGE. Discordant segments were then analyzed offline using delayed signal intensity of >2 and >5 standard deviations above normal myocardium.
Results
Of 90 consecutive patients, 32 (36%) patients with septal (n = 16), free wall (n = 14) or both (n = 2) MRI-voltage + mismatch were identified. All discordant segments demonstrated unipolar voltage abnormalities with 12 patients (6 septal and 6 free wall) also showing low bipolar voltage but no LGE at signal intensity >5 standard deviations. Eleven patients (5 septum, 6 free wall) had VT localized to discordant areas. Ninety-three percent of patients in the septal group (26/48 segments) and 89% of patients in the free wall group (9/13 segments) had a concordant response established by using a signal intensity cutoff of >2 standard deviations.
Conclusions
MRI-voltage discordance was identified in 36% of patients with non-ischemic LV-VT/VPD who underwent VT ablation. In 12% of patients, VT was targeted in areas of abnormal voltage not suggested by routine qualitative MRI. Quantitative MRI analysis using a lower signal intensity threshold increased the sensitivity for detecting areas of clinically relevant VT substrate.
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Data is collected in a registry approved by the University of Pennsylvania Investigational Review Board and informed consent is obtained on all patients prior to procedures.
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Supported in part by The Richard T. and Angela Clark Innovation Fund in Cardiac Electrophysiology and The F. Harlan Batrus Research Fund.
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The authors declare that they have no conflict of interest.
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Betensky, B.P., Dong, W., D’Souza, B.A. et al. Cardiac magnetic resonance imaging and electroanatomic voltage discordance in non-ischemic left ventricle ventricular tachycardia and premature ventricular depolarizations. J Interv Card Electrophysiol 49, 11–19 (2017). https://doi.org/10.1007/s10840-017-0228-8
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DOI: https://doi.org/10.1007/s10840-017-0228-8