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Left atrial posterior wall isolation reduces the recurrence of atrial fibrillation: a meta-analysis

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Abstract

Purpose

The posterior wall of left atrium plays an important role in atrial fibrillation (AF) recurrence, but the benefit of left atrial posterior wall isolation (PWI) remains still unclear. The objective was to evaluate the benefit of PWI in radiofrequency ablation.

Methods

PubMed and the Web of Science were searched in September 2015. Studies comparing catheter ablation with PWI [PWI(+)] vs. ablation without PWI [PWI(−)] were included. We performed a meta-analysis to assess atrial arrhythmia recurrence, procedure-related complications, and procedural time.

Results

Five studies with 594 AF patients were included. Compared with PWI(−), PWI(+) resulted in a significantly lower atrial arrhythmia recurrence rate (relative risk [RR] 0.81, 95 % confidence interval [CI] 0.68–0.97, p = 0.02), which was largely driven by the decreased AF recurrence (RR 0.55, 95 % CI 0.35–0.86, p = 0.009). Recurrence rates of atrial tachycardia/flutter (AT/AFL) were comparable between two groups (RR 1.16, 95 % CI 0.85–1.58, p = 0.34). There were no significant differences in procedure-related complications (RR 1.07, 95 % CI 0.45–2.53, p = 0.89) and procedural times (weight mean difference 0.88, 95 % CI −7.29–9.06, p = 0.83).

Conclusions

This meta-analysis shows that with comparable procedure-related complications and procedural time, ablation with PWI reduces AF recurrence.

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Abbreviations

AF:

Atrial fibrillation

PWI:

Posterior wall isolation

PVI:

Pulmonary vein isolation

AT:

Atrial tachycardia

AFL:

Atrial flutter

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Authors and Affiliations

  1. Department of Cardiology, The First Affiliated Hospital of Sun Yat-sen University, No.58, 2nd Zhongshan Road, Yuexiu District, Guangzhou, Guangdong, China

    Xin He, Yue Zhou, Yili Chen, Lingling Wu & Jiangui He

  2. Emergency Department, The First Affiliated Hospital of Sun Yat-sen University, No.58, 2nd Zhongshan Road, Yuexiu District, Guangzhou, Guangdong, China

    Yiyi Huang

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  1. Xin He
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Correspondence to Jiangui He.

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He, X., Zhou, Y., Chen, Y. et al. Left atrial posterior wall isolation reduces the recurrence of atrial fibrillation: a meta-analysis. J Interv Card Electrophysiol 46, 267–274 (2016). https://doi.org/10.1007/s10840-016-0124-7

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  • DOI: https://doi.org/10.1007/s10840-016-0124-7

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