Abstract
Purpose
In ablation of atrial fibrillation, the single-ring method aims for isolation of the posterior wall of the left atrium (LA) including the pulmonary veins (PVs) but avoiding posterior LA lesions. The aim of this randomized prospective study was to evaluate safety and efficacy of remote magnetic navigation (RMN)-guided single-ring ablation strategy as compared to standard RMN-guided circumferential PV ablation (PVA).
Methods
Eighty consecutive patients undergoing PVA were enrolled prospectively and randomized equally into two study groups. RMN using the Stereotaxis system and open-irrigated 3.5-mm ablation catheters were used with a 3D mapping system in all procedures. Forty patients underwent RMN-guided single-ring ablation, and 40 patients received RMN-guided circumferential PVA.
Results
In the circumferential group, 3.3 ± 1.1 PVs were successfully isolated at the end of the procedure as compared to 3.1 ± 1.3 in the single-ring (box) group (p = 0.38). All patients in the box group required additional posterior lesions in order to achieve electrical isolation of the PVs. Single-ring ablation was associated with longer procedure duration (p = 0.01) and ablation time (p = 0.001). After a single procedure, the proportion of patients free of any atrial tachycardia (AT)/atrial fibrillation (AF) episode at 12-month follow-up was 57 % in the box group and 58 % in the circ group. Using RMN, only minor complications have been observed.
Conclusions
RMN-guided single-ring PVA provides comparable acute and long-term success rates as compared to RMN-guided circumferential PVA but requires additional posterior lesions to achieve PV isolation and increased procedure and ablation time. Procedural complication rates are low when using RMN.
Similar content being viewed by others
References
Fuster, V., Rydén, L. E., Cannom, D. S., Crijns, H. J., Curtis, A. B., Ellenbogen, K. A., et al. (2006). American College of Cardiology/American Heart Association Task Force on Practice Guidelines; European Society of Cardiology Committee for Practice Guidelines; European Heart Rhythm Association; Heart Rhythm Society. ACC/AHA/ESC 2006 guidelines for the management of patients with atrial fibrillation: a report of the American College of Cardiology/American Heart Association Task Force on practice guidelines and the European society of cardiology committee for practice guidelines (writing committee to revise the 2001 guidelines for the management of patients with atrial fibrillation): developed in collaboration with the European Heart Rhythm Association and the Heart Rhythm Society. Circulation, 114, e257–e354.
Willems, S., Drewitz, I., Steven, D., Hoffmann, B., Meinertz, T., & Rostock, T. (2010). Interventional therapy of atrial fibrillation: possibilities and limitations. Deutsche Medizinische Wochenschrift, 135, S48–S54.
Cappato, R., Calkins, H., Chen, S. A., Davies, W., Iesaka, Y., Kalman, J., et al. (2010). Ablation for human atrial fibrillation. Updated worldwide survey on the methods, efficacy, and safety of catheter. Circulation. Arrhythmia and Electrophysiology, 3, 32–38.
Ernst, S. (2009). The future of atrial fibrillation ablation: new technologies and indications: atrial fibrillation. Heart, 95, 158–163.
Vollmann, D., Lüthje, L., Seegers, J., Hasenfuss, G., & Zabel, M. (2009). Remote magnetic catheter navigation for cavotricuspid isthmus ablation in patients with common-type atrial flutter. Circulation. Arrhythmia and Electrophysiology, 2, 603–610.
Arya, A., Zaker-Shahrak, R., Sommer, P., Bollmann, A., Wetzel, U., Gaspar, T., et al. (2011). Catheter ablation of atrial fibrillation using remote magnetic catheter navigation: a case–control study. Europace, 13, 45–50.
Lüthje, L., Vollmann, D., Seegers, J., Dorenkamp, M., & Sohns, C. (2011). Hasenfuss Get al. Remote magnetic versus manual catheter navigation for circumferential pulmonary vein ablation in patients with atrial fibrillation. Clinical Research in Cardiology, 100, 1003–1011.
Pappone, C., Vicedomini, G., Manguso, F., Gugliotta, F., Mazzone, P., Gulletta, S., et al. (2006). Robotic magnetic navigation for atrial fibrillation ablation. Journal of the American College of Cardiology, 47, 1390–1400.
Chun, K. R., Wissner, E., Koektuerk, B., Konstantinidou, M., Schmidt, B., Zerm, T., et al. (2010). Remote-controlled magnetic pulmonary vein isolation utilizing a new irrigated tip catheter in patients with atrial fibrillation. Circulation. Arrhythmia and Electrophysiology, 3, 458–464.
Di Biase, L., Fahmy, T. S., Patel, D., Bai, R., Civello, K., Wazni, O. M., et al. (2007). Remote magnetic navigation: human experience in pulmonary vein ablation. Journal of the American College of Cardiology, 50, 868–874.
Katsiyiannis, W., Melby, D., Matelski, J., Ervin, V., Laverence, K., & Gornick, C. (2008). Feasibility and safety of remote-controlled magnetic navigation for ablation of atrial fibrillation. American Journal of Cardiology, 102, 1674–1676.
Bauernfeind, T., Akca, F., Schwagten, B., de Groot, N., Van Belle, Y., Valk, S., et al. (2011). The magnetic navigation system allows safety and high efficacy for ablation of arrhythmias. Europace, 13, 1015–1021.
Thomas, S., Lim, T., McCall, R., Seow, S., & Ross, D. (2007). Electrical isolation of the posterior left atrial wall and pulmonary veins for atrial fibrillation: feasibility of and rationale for a single-ring approach. Heart Rhythm, 4, 722–730.
Lim, T. W., Koay, C. H., McCall, R., See, V. A., Ross, D. L., & Thomas, S. P. (2008). Atrial arrhythmias after single-ring isolation of the posterior left atrium and pulmonary veins for atrial fibrillation: mechanisms and management. Circulation. Arrhythmia and Electrophysiology, 1, 120–126.
Eitel, C., Hindricks, G., Sommer, P., Gaspar, T., Kircher, S., Wetzel, U., et al. (2010). Circumferential pulmonary vein isolation and linear left atrial ablation as a single-catheter technique to achieve bidirectional conduction block: the pace-and-ablate approach. Heart Rhythm, 7, 157–164.
Steven, D., Reddy, V. Y., Inada, K., Roberts-Thomson, K. C., Seiler, J., Stevenson, W. G., et al. (2010). Loss of pace capture on the ablation line: a new marker for complete radiofrequency lesions to achieve pulmonary vein isolation. Heart Rhythm, 7, 323–330.
Tamborero, D., Mont, L., Berruezo, A., Matiello, M., Benito, B., Sitges, M., et al. (2009). Left atrial posterior wall isolation does not improve the outcome of circumferential pulmonary vein ablation for atrial fibrillation: a prospective randomized study. Circulation. Arrhythmia and Electrophysiology, 2, 35–40.
Sawhney, N., Anousheh, R., Chen, W., & Feld, G. K. (2010). Circumferential pulmonary vein ablation with additional linear ablation results in an increased incidence of left atrial flutter compared with segmental pulmonary vein isolation as an initial approach to ablation of paroxysmal atrial fibrillation. Circulation. Arrhythmia and Electrophysiology, 3, 243–248.
Chilukuri, K., Scherr, D., Dalal, D., Cheng, A., Spragg, D., Nazarian, S., et al. (2011). Conventional pulmonary vein isolation compared with the “box isolationˮ method: a randomized clinical trial. Journal of Interventional Cardiac Electrophysiology, 32, 137–146.
Kuck, K. H., Reddy, V. Y., Schmidt, B., Natale, A., Neuzil, P., Saoudi, N., et al. (2012). A novel radiofrequency ablation catheter using contact force sensing: Toccata study. Heart Rhythm, 9, 18–23.
Sohns C, Karim R, Harrison J, Arujuna A, Linton N, Sennett R et al. (2013) Quantitative magnetic resonance imaging analysis of the relationship between contact force and left atrial scar formation after catheter ablation of atrial fibrillation. Journal of Cardiovascular Electrophysiology.
Ernst, S., Ouyang, F., Löber, F., Antz, M., & Kuck, K. H. (2003). Catheter-induced linear lesions in the left atrium in patients with atrial fibrillation: an electroanatomic study. Journal of the American College of Cardiology, 42, 1271–1282.
Kumagai, K., Muraoka, S., Mitsutake, C., Takashima, H., & Nakashima, H. (2007). A new approach for complete isolation of the posterior left atrium including pulmonary veins for atrial fibrillation. Journal of Cardiovascular Electrophysiology, 18, 1047–1052.
Lim, T. W., Koay, C. H., See, V. A., McCall, R., Chik, W., Zecchin, R., et al. (2012). Single-ring posterior left atrial (box) isolation results in a different mode of recurrence compared with wide antral pulmonary vein isolation on long-term follow-up: longer atrial fibrillation-free survival time but similar survival time free of any atrial arrhythmia. Circulation. Arrhythmia and Electrophysiology, 5(5), 968–977.
Augello, G., Vicedomini, G., Saviano, M., Crisa, S., Mazzone, P., Ornago, O., et al. (2009). Pulmonary vein isolation after circumferential pulmonary vein ablation: comparison between Lasso and three-dimensional electroanatomical assessment of complete electrical disconnection. Heart Rhythm, 6, 1706–1713.
Hachiya, H., Hirao, K., Takahashi, A., Nagata, Y., Suzuki, K., Maeda, S., et al. (2007). Clinical implications of reconnection between the left atrium and isolated pulmonary veins provoked by adenosine triphosphate after extensive encircling pulmonary vein isolation. Journal of Cardiovascular Electrophysiology, 18, 392–398.
Matsuo, S., Yamane, T., Date, T., Inada, K., Kanzaki, Y., Tokuda, M., et al. (2007). Reduction of AF recurrence after pulmonary vein isolation by eliminating ATP-induced transient venous re-conduction. Journal of Cardiovascular Electrophysiology, 18, 704–708.
Conflict of interest
Drs. Vollmann and Zabel have received moderate grant support from Stereotaxis. The study was supported by an unrestricted research grant by Stereotaxis, Inc.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Sohns, C., Bergau, L., Seegers, J. et al. Single-ring ablation compared with standard circumferential pulmonary vein isolation using remote magnetic catheter navigation. J Interv Card Electrophysiol 41, 75–82 (2014). https://doi.org/10.1007/s10840-014-9915-x
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10840-014-9915-x