Journal of Computational Neuroscience

, Volume 36, Issue 2, pp 235–257

Mimicking human neuronal pathways in silico: an emergent model on the effective connectivity

  • Önder Gürcan
  • Kemal S. Türker
  • Jean-Pierre Mano
  • Carole Bernon
  • Oğuz Dikenelli
  • Pierre Glize
Article

DOI: 10.1007/s10827-013-0467-3

Cite this article as:
Gürcan, Ö., Türker, K.S., Mano, J. et al. J Comput Neurosci (2014) 36: 235. doi:10.1007/s10827-013-0467-3

Abstract

We present a novel computational model that detects temporal configurations of a given human neuronal pathway and constructs its artificial replication. This poses a great challenge since direct recordings from individual neurons are impossible in the human central nervous system and therefore the underlying neuronal pathway has to be considered as a black box. For tackling this challenge, we used a branch of complex systems modeling called artificial self-organization in which large sets of software entities interacting locally give rise to bottom-up collective behaviors. The result is an emergent model where each software entity represents an integrate-and-fire neuron. We then applied the model to the reflex responses of single motor units obtained from conscious human subjects. Experimental results show that the model recovers functionality of real human neuronal pathways by comparing it to appropriate surrogate data. What makes the model promising is the fact that, to the best of our knowledge, it is the first realistic model to self-wire an artificial neuronal network by efficiently combining neuroscience with artificial self-organization. Although there is no evidence yet of the model’s connectivity mapping onto the human connectivity, we anticipate this model will help neuroscientists to learn much more about human neuronal networks, and could also be used for predicting hypotheses to lead future experiments.

Keywords

Human studiesSelf-organizationAgent-based simulationSpiking neural networksIntegrate-and-fire modelFrequency analysis

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Önder Gürcan
    • 1
    • 3
  • Kemal S. Türker
    • 2
  • Jean-Pierre Mano
    • 4
  • Carole Bernon
    • 3
  • Oğuz Dikenelli
    • 1
  • Pierre Glize
    • 3
  1. 1.Computer Engineering DepartmentEge UniversityBornovaTurkey
  2. 2.School of MedicineKoc UniversitySariyerTurkey
  3. 3.IRIT LaboratoryUniversite Paul SabatierToulouseFrance
  4. 4.UpetecRamonville-Saint-AgneFrance