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Contribution of TIMP3 polymorphisms to the development of preeclampsia in Han Chinese women

  • Genetics
  • Published:
Journal of Assisted Reproduction and Genetics Aims and scope Submit manuscript

Abstract

Purpose

The aim of this study was to investigate whether polymorphisms in the tissue inhibitor of metalloproteinase 3 gene (TIMP3) are associated with the risk of preeclampsia (PE) in Han Chinese women.

Methods

Nine single TIMP3 tag-single nucleotide polymorphisms were selected by Haploview and genotyped using the Sequenom method in 181 preeclamptic and 203 healthy pregnant women from eastern China.

Results

The allele frequencies of the tag-single nucleotide polymorphisms were not significantly different between groups (P > 0.05). However, the genotype distribution of rs135025 was shown to differ between the multigravidity PE subgroup (>3) and controls under additive (P = 0.018) and recessive models (P = 0.008), while the genotype distribution of rs80272 differed significantly between the severe PE subgroup and controls under additive (P = 0.014) and dominant models (P = 0.041). Moreover, the H2 haplotype (A-C-G-T-A-A-G-C-G) was found to be associated with the risk of PE (P = 0.035).

Conclusions

Genotypes of rs135025 and rs80272 in TIMP3 may therefore influence susceptibility to PE, and pregnant women carrying the H2 haplotype might be more prone to developing PE.

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Acknowledgments

We thank Professor Hui Li from Shengjing Hospital of China Medical University for providing samples. We especially thank all of the participants for their contributions to the research. This study was supported by the National International Scientific and Technological Cooperation Programme 2012DFB30130.

Conflict of interest

The authors declare that they have no conflict of interest.

Author information

Authors and Affiliations

  1. National Research Institute for Family Planning, 12 Dahuisi Road, Haidian, Beijing, 100081, China

    Changlong Guo, Xiaofang Cao, Qidi Wang, Guangyu Wang, Lisha An, Meng Du, Yue Qiu, Ying Yang, Xingyu Wang & Xu Ma

  2. Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China

    Hui Li, Yuting Wang & Shuo Wang

  3. Graduate School of Peking Union Medical College, Beijing, China

    Xu Ma

  4. World Health Organization Collaborating Centre for Research in Human Reproduction, Beijing, China

    Xu Ma

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  1. Changlong Guo
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  2. Xiaofang Cao
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  4. Guangyu Wang
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Corresponding authors

Correspondence to Xingyu Wang or Xu Ma.

Additional information

Capsule TIMP3 rs135025 and rs80272 polymorphisms may influence susceptibility to PE in Han Chinesewomen.

Changlong Guo and Xiaofang Cao These two authors equally contributed to this work.

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Guo, C., Cao, X., Wang, Q. et al. Contribution of TIMP3 polymorphisms to the development of preeclampsia in Han Chinese women. J Assist Reprod Genet 32, 1525–1530 (2015). https://doi.org/10.1007/s10815-015-0529-8

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