Skip to main content
SpringerLink
Log in

Reproductive outcome of women 43 years and beyond undergoing ART treatment with their own oocytes in two Connecticut university programs

  • ASSISTED REPRODUCTION TECHNOLOGIES
  • Published:
Journal of Assisted Reproduction and Genetics Aims and scope Submit manuscript

Abstract

Purpose

The aim of this study was to analyze the outcomes of IVF/ICSI cycles in women aged 43 and beyond.

Methods

Retrospective analysis of clinical pregnancy and live birth rates in168 fresh, non donor, ART cycles performed in two Connecticut university IVF programs.

Results

In women of 43 and 44 years the overall clinical pregnancy and live birth rates were 8.3 % and 5.3 % per initiated cycle, respectively. There were no clinical pregnancies in women ≥45 years old. First cycle characteristics were not different from repeated cycles in terms of duration of ovulation induction, number of collected oocytes and transferred embryos (p > 0.05).

Conclusions

Pregnancies can still be achieved with IVF/ICSI up to the age of 44. Since most pregnancies occurred within the first 3 cycles, another attempt may be a reasonable option before resorting to oocyte donation for patients who failed two previous cycles. Women 45 years and beyond do not benefit from ART procedures using their own oocytes.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Bopp BL, Alper MM, Thompson IE, Mortola J. Success rates with gamete intrafallopian transfer and in vitro fertilization in women of advanced maternal age. Fertil Steril. 1995;63:1278–83.

    PubMed  CAS  Google Scholar 

  2. Doldi N, Persico P, De SL, Rabellotti E, Papaleo E, Ferrari A. Consecutive cycles in in vitro fertilization-embryo transfer. Gynecol Endocrinol. 2005;20:132–6.

    Article  PubMed  Google Scholar 

  3. Elizur SE, Lerner-Geva L, Levron J, Shulman A, Bider D, Dor J. Cumulative live birth rate following in vitro fertilization: study of 5,310 cycles. Gynecol Endocrinol. 2006;22:25–30.

    Article  PubMed  Google Scholar 

  4. Gardner DK, Schoolcraft WB. In vitro culture of human blastocysts. In: Jansen R, Mortimer D, editors. Towards reproductive certainty: Infertility and genetics beyond. Carnforth: Parthenon Press; 1999. p. 378.

    Google Scholar 

  5. Gielchinsky Y, Mazor M, Simon A, Mor-Yossef S, Laufer N. Natural conception after age 45 in Bedouin women, a uniquely fertile population. J Assist Reprod Genet. 2006;23:305–9.

    Article  PubMed  Google Scholar 

  6. Grimbizis G, Vandervorst M, Camus M, Tournaye H, Van SA, Devroey P. Intracytoplasmic sperm injection, results in women older than 39, according to age and the number of embryos replaced in selective or non-selective transfers. Hum Reprod. 1998;13:884–9.

    Article  PubMed  CAS  Google Scholar 

  7. Guzick DS, Wilkes C, Jones Jr HW. Cumulative pregnancy rates for in vitro fertilization. Fertil Steril. 1986;46:663–7.

    PubMed  CAS  Google Scholar 

  8. Handyside AH, Montag M, Magli MC, Repping S, Harper J, Schmutzler A, et al. Multiple meiotic errors caused by predivision of chromatids in women of advanced maternal age undergoing in vitro fertilisation. Eur J Hum Genet. 2012;20(7):742–7.

    Article  PubMed  Google Scholar 

  9. Jain T. Socioeconomic and racial disparities among infertility patients seeking care. Fertil Steril. 2006;85:876–81.

    Article  PubMed  Google Scholar 

  10. Jain T, Harlow BL, Hornstein MD. Insurance coverage and outcomes of in vitro fertilization. N Engl J Med. 2002;347:661–6.

    Article  PubMed  Google Scholar 

  11. Klipstein S, Regan M, Ryley DA, Goldman MB, Alper MM, Reindollar RH. One last chance for pregnancy: a review of 2,705 in vitro fertilization cycles initiated in women age 40 years and above. Fertil Steril. 2005;84:435–45.

    Article  PubMed  Google Scholar 

  12. Lass A, Croucher C, Duffy S, Dawson K, Margara R, Winston RM. One thousand initiated cycles of in vitro fertilization in women > or = 40 years of age. Fertil Steril. 1998;70:1030–4.

    Article  PubMed  CAS  Google Scholar 

  13. Laufer N, Simon A, Samueloff A, Yaffe H, Milwidsky A, Gielchinsky Y. Successful spontaneous pregnancies in women older than 45 years. Fertil Steril. 2004;81:1328–32.

    Article  PubMed  Google Scholar 

  14. Malizia BA, Hacker MR, Penzias AS. Cumulative live-birth rates after in vitro fertilization. N Engl J Med. 2009;360:236–43.

    Article  PubMed  CAS  Google Scholar 

  15. Martin JR, Bromer JG, Sakkas D, Patrizio P. Insurance coverage and in vitro fertilization outcomes: a U.S. perspective. Fertil Steril. 2011;95:964–9.

    Article  PubMed  Google Scholar 

  16. Orvieto R, Bar-Hava I, Yoeli R, Ashkenazi J, Rabinerson D, Bar J, et al. Results of in vitro fertilization cycles in women aged 43–45 years. Gynecol Endocrinol. 2004;18:75–8.

    Article  PubMed  CAS  Google Scholar 

  17. Patrizio P, Bianchi V, Lalioti MD, Gerasimova T, Sakkas D. High rate of biological loss in assisted reproduction: it is in the seed, not in the soil. Reprod Biomed Online. 2007;14:92–5.

    Article  PubMed  CAS  Google Scholar 

  18. Roest J, Van Heusden AM, Mous H, Zeilmaker GH, Verhoeff A. The ovarian response as a predictor for successful in vitro fertilization treatment after the age of 40 years. Fertil Steril. 1996;66:969–73.

    PubMed  CAS  Google Scholar 

  19. Ron-el R, Raziel A, Strassburger D, Schachter M, Kasterstein E, Friedler S. Outcome of assisted reproductive technology in women over the age of 41. Fertil Steril. 2000;74:471–5.

    Article  PubMed  CAS  Google Scholar 

  20. Schoolcraft WB, Katz-Jaffe MG, Stevens J, Rawlins M, Munne S. Preimplantation aneuploidy testing for infertile patients of advanced maternal age: a randomized prospective trial. Fertil Steril. 2009;92:157–62.

    Article  PubMed  Google Scholar 

  21. Sharma V, Allgar V, Rajkhowa M. Factors influencing the cumulative conception rate and discontinuation of in vitro fertilization treatment for infertility. Fertil Steril. 2002;78:40–6.

    Article  PubMed  Google Scholar 

  22. Society of Assisted Reproductive Technology (SART). 2009. National Data Report https://www.sartcorsonline.com/rptCSR_PublicMultYear.aspx?ClinicPKID=0.

  23. Tan SL, Royston P, Campbell S, Jacobs HS, Betts J, Mason B, et al. Cumulative conception and livebirth rates after in-vitro fertilisation. Lancet. 1992;339:1390–4.

    Article  PubMed  CAS  Google Scholar 

  24. Tsafrir A, Simon A, Revel A, Reubinoff B, Lewin A, Laufer N. Retrospective analysis of 1217 IVF cycles in women aged 40 years and older. Reprod Biomed Online. 2007;14:348–55.

    Article  PubMed  CAS  Google Scholar 

  25. van Dissledorp DJ, Eijkemans MJ, Klinkert ER, te Velde ER, Fauser BC, Broekmans FJ. Cumulative live birth rates following IVF in 41- to 43-year-old women presenting with favourable ovarian reserve characteristics. Reprod Biomed Online. 2007;14:455–63.

    Article  Google Scholar 

  26. Wright VC, Chang J, Jeng G, Macaluso M. Assisted reproductive technology surveillance–United States, 2005. MMWR Surveill Summ. 2008;57:1–23.

    PubMed  Google Scholar 

  27. Zou YL, Liao SL, Yang H, Chen RC, Huang DQ, Li SY, et al. Study on the unintended pregnancy among married women of child-bearing age living in Qingshan district, Wuhan. Zhonghua Liu Xing Bing Xue Za Zhi. 2012;33:291–5.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Obstetrics, Gynecology and Reproductive Sciences, Yale University Fertility Center, New Haven, CT, 06511, USA

    Mehmet B. Cetinkaya, Denny Sakkas & Pasquale Patrizio

  2. School of Medicine, Departments of Obstetrics and Gynecology, University of Ondokuz Mayıs, 55139, Samsun, Turkey

    Mehmet B. Cetinkaya

  3. Center for Advanced Reproductive Services, University of Connecticut Health Center, Farmington, CT, 06030, USA

    Linda J. Siano & Claudio Benadiva

Authors
  1. Mehmet B. Cetinkaya
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Linda J. Siano
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Claudio Benadiva
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Denny Sakkas
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Pasquale Patrizio
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Pasquale Patrizio.

Additional information

Capsule

Women ≥45 years old do not benefit from ART procedures using their own oocytes.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Cetinkaya, M.B., Siano, L.J., Benadiva, C. et al. Reproductive outcome of women 43 years and beyond undergoing ART treatment with their own oocytes in two Connecticut university programs. J Assist Reprod Genet 30, 673–678 (2013). https://doi.org/10.1007/s10815-013-9981-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10815-013-9981-5

Keywords

Search

Navigation