, Volume 29, Issue 5, pp 433-435
Date: 12 Feb 2012

Oocyte retrieval following continued stimulation five days beyond ovulation yields live birth after frozen embryo transfer

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There is often a narrow time window for cancer patients to accomplish fertility preservation before cancer treatment initiation. Despite attempts at pituitary blockade, premature ovulation prior to oocyte retrieval may occur. In that situation, conventional practice dictates cancellation of the cycle. There is no existing literature regarding oocyte quality and yield in stimulated cycles in which ovulation occurs in the early follicular phase prior to hCG trigger. Here we report a case of continued ovarian stimulation 3 days beyond documented ovulation in a woman with breast cancer, with the cycle yielding embryos capable of resulting in a successful twin pregnancy after transfer to a gestational surrogate.

Case report

A 40-year-old gravida1 para 0 who had recently undergone bilateral mastectomy for invasive ductal carcinoma desired fertility preservation prior to chemotherapy and prophylactic bilateral salpingo-oophorectomy. She planned to take adjuvant hormonal therapy for ...

Presented at: Pacific Coast Reproductive Society, 59th annual meeting, April 2011
Where the work was done: Stanford Fertility and Reproductive Medicine Center, Palo Alto, California.
Capsule A 40-year-old with breast cancer underwent retrieval five days after ovulation and frozen embryo transfer to gestational surrogate resulted in live birth of twins. Continuous ovarian stimulation despite ovulation can yield embryos capable of resulting in viable pregnancy.