Date: 27 May 2011
Umbilical cord blood banking: an update
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.Get Access
Umbilical cord blood is a potential vast source of primitive hematopoietic stem and progenitor cells available for clinical application to reconstitute the hematopoietic system and/or restore immunological function in affected individuals requiring treatment. Cord blood can be used as an alternative source for bone marrow transplantation and its use is developing into a new field of treatment for pediatric and adult patients presenting with hematological disorders, immunological defects and specific genetic diseases.
More than 25,000 allogeneic cord blood transplantations have been performed worldwide since the first cord blood transplantation in 1988. There are two banking options for storing umbilical cord blood [private (family) and public]. Cord blood stored in private banks are used for either autologous or allogeneic transplants for the infant donor or related family members but private cord blood banks are not searchable or available to the public. More than 780,000 cord blood units are stored in over 130 private cord blood banks, worldwide, and over 400,000 units in more than 100 quality controlled public cord blood banks.
Researchers continue to evaluate the usefulness of cord blood cells in treating human diseases or disorders for purposes other than hematological disorders including heart disease, strokes, brain or spinal cord injuries and cancer. This review summarizes the status of umbilical cord blood banking, its history and current and potential use in the treatment of human disease.
Capsule Umbilical cord blood which is readily available and stored in either private or public cord blood banks is an alternative source of cells for transplantation purposes for pediatric and adult patients with malignancies, hemoglobinopathies, metabolic disorders, immune deficiences and potentially for regenerative applications.
Prasad VK, Mendizabal A, Parikh SH, Szabolcs P, Driscoll TA, Page K, et al. Unrelated donor umbilical cord blood transplantation for inherited metabolic disorders in 159 pediatric patients from a single center: influence of cellular composition of the graft on transplantation outcomes. Blood. 2008;112:2979–89.PubMedCrossRef
Wagner JE, Barker JN, DeFor TE, Baker KS, Blazar BR, Eide C, et al. Transplantation of unrelated donor umbilical cord blood in 102 patients with malignant and nonmalignant diseases: influence of CD34 cell dose and HLA disparity on treatment-related mortality and survival. Blood. 2002;100:1611–18.PubMed
Salfilippo JS, Barnhard Y, Bahceci E, Bayer-Zwirello L, Donnenfeld AE, Mason BA et al. Family cord blood banking: What you need to know? OBG Management (Suppl). Nov. 2007; S1-S8.
Rubinstein P, Taylor PE, Scaradavou A, Adamson JW, Migliaccio G, Emanuel D, et al. Unrelated placental blood for bone marrow reconstitution: organization of the placental blood program. Blood Cells. 1994;20:587–96.PubMed
NETCORD-Fact: Internatioanal Standards for Cord Blood Collection, Processing, Testing, Banking, Selection and Release, 4th ed. Omaha, FACT, 2008. http://www.factwebsite.org/Standards/. Accessed January 7, 2011.
Greaves M. Pre-natal origins of childhood leukemia. Rev Clin Exp Hematol. 2003;7:233–45.PubMed
Samuel GN, Kerridge IH, O’Brien TA. Umbilical cord blood banking: public good or private benefit? Med J Aust. 2008;188:533–55.PubMed
Sun J, Allison J, McLaughlin C, Sledge L, Waters-Pick B, Wease S, et al. Differences in quality between privately and publicly banked umbilical cord blood units: a pilot study of autologous cord blood infusion in children with acquired neurologic disorders. Transfusion. 2010;50:1980–87.PubMedCrossRef
Yang H, Loutfy MR, Mayerhofer S, Shuen P. Factors affecting banking quality of umbilical cord blood for transplantation. Transfusion. 2011;51:286–92.CrossRef
Reagan DM, Wofford JD, Wall DA. Comparison of cord blood thawing methods on cell recovery, potency, and infusion. Transfusion. 2010;50:2670–75.CrossRef
Wofford JD. Adult transplant outcomes, single versus pooled blood transplants. Biol Blood Marrow Transplant. 2005;11(Suppl1):2.CrossRef
Peters C, Shapiro EG, Anderson J, Henslee-Downey PJ, Klemperer MR, Cowan MJ, et al. Hurler syndrome: II. Outcome of HLA-genotypically identical sibling and HLA-haploidentical related donor bone marrow transplantation in fifty-four children. The Storage Disease Collaborative Study Group. Blood. 1998;91:2601–08.PubMed
Newcomb JD, Willing AE, Sanberg PR. Umbilical cord blood cells. Meth Mol Biol. 2009;549:119–36.CrossRef
Copeland N, Harris D, Gaballa MA. Human umbilical cord blood stem cells, myocardial infarction and stroke. Clin Med. 2009;9:342–45.PubMed
Sanberg PR, Eve DJ, Willing AE, Garbuzova-Davis S, Tan J, Sanberg CD et al. The treatment of neurodegenerative disorders using umbilical cord blood and menstrual blood-derived stem cells. Cell Transplant. 2010; Sep 30 [Epub ahead of print].
Ende N, Chen R. Parkinson’s disease mice and human umbilical cord blood. J Med. 2002;33:173–80.PubMed
Ende N, Chen R, Ende-Harris D. Human umbilical cord blood cells ameliorate Alzheimer’s disease in transgenic mice. J Med. 2001;32:241–47.PubMed
Ende N, Chen R. Human umbilical cord blood cells ameliorate Huntington’s disease in transgenic mice. J Med. 2001;32:231–40.PubMed
Chen R, Ende N. The potential for the use of mononuclear cells from human umbilical cord blood in the treatment of amyotrophic lateral sclerosis in SOD1 mice. J Med. 2000;31:21–30.PubMed
Arien-Zakay H, Lazarovici P, Nagler A. Tissue regeneration potential in human umbilical cord blood. 2010;23:291–303.
Forraz N, McGuckin CP. The umbilical cord: a rich and ethical stem cell source to advance regenerative medicine. 2011;44(Suppl 1):66–9.
US National Institues of Health. Umbilical cord blood infusion to treat type 1 diabetes. http://www.clinicaltrials.gov/ct2/search, NCT0030544. Accessed January 7, 2011.
National Guidelines Clearing House. Cord blood banking for potential future transplantation. http://www.guidelines.gov/content.aspx?id=10389. Accessed January 7, 2011.
- Umbilical cord blood banking: an update
Journal of Assisted Reproduction and Genetics
Volume 28, Issue 8 , pp 669-676
- Cover Date
- Print ISSN
- Online ISSN
- Springer US
- Additional Links
- Umbilical cord blood
- Public and private cord blood banks
- Clinical applications
- Regenerative medicine
- Industry Sectors