Umbilical cord blood banking: an update
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Umbilical cord blood is a potential vast source of primitive hematopoietic stem and progenitor cells available for clinical application to reconstitute the hematopoietic system and/or restore immunological function in affected individuals requiring treatment. Cord blood can be used as an alternative source for bone marrow transplantation and its use is developing into a new field of treatment for pediatric and adult patients presenting with hematological disorders, immunological defects and specific genetic diseases.
More than 25,000 allogeneic cord blood transplantations have been performed worldwide since the first cord blood transplantation in 1988. There are two banking options for storing umbilical cord blood [private (family) and public]. Cord blood stored in private banks are used for either autologous or allogeneic transplants for the infant donor or related family members but private cord blood banks are not searchable or available to the public. More than 780,000 cord blood units are stored in over 130 private cord blood banks, worldwide, and over 400,000 units in more than 100 quality controlled public cord blood banks.
Researchers continue to evaluate the usefulness of cord blood cells in treating human diseases or disorders for purposes other than hematological disorders including heart disease, strokes, brain or spinal cord injuries and cancer. This review summarizes the status of umbilical cord blood banking, its history and current and potential use in the treatment of human disease.
- Hwang, WY, Samuel, M, Tan, D, Koh, LP, Lim, W, Linn, YC (2007) A meta-analysis of unrelated donor umbilical cord blood transplantation versus unrelated donor bone marrow transplantation in adult and pediatric patients. Biol Blood Marrow Transplant 13: pp. 444-53 CrossRef
- Frangoul, H, Wang, L, Harrell, FE, Manes, B, Calder, C, Domm, J (2010) Unrelated umbilical cord blood transplantation in children with immune deficiency: results of a multicenter study. Bone Marrow Transplant 45: pp. 283-8 CrossRef
- Prasad, VK, Mendizabal, A, Parikh, SH, Szabolcs, P, Driscoll, TA, Page, K (2008) Unrelated donor umbilical cord blood transplantation for inherited metabolic disorders in 159 pediatric patients from a single center: influence of cellular composition of the graft on transplantation outcomes. Blood 112: pp. 2979-89 CrossRef
- Eapen, M, Rubinstein, P, Zhang, MJ, Stevens, C, Kurtzberg, J, Scaradavou, A (2007) Outcomes of transplantation of unrelated donor umbilical cord blood and bone marrow in children with acute leukaemia: a comparison study. Lancet 369: pp. 1947-54 CrossRef
- Laughlin, MJ, Eapen, M, Rubinstein, P, Wagner, JE, Zhang, MJ, Champlin, RE (2004) Outcomes after transplantation of cord blood or bone marrow from unrelated donors in adults with leukemia. N Engl J Med 351: pp. 2265-75 CrossRef
- Wagner, JE, Barker, JN, DeFor, TE, Baker, KS, Blazar, BR, Eide, C (2002) Transplantation of unrelated donor umbilical cord blood in 102 patients with malignant and nonmalignant diseases: influence of CD34 cell dose and HLA disparity on treatment-related mortality and survival. Blood 100: pp. 1611-18
- Smythe, J, Armitage, S, McDonald, D, Pamphilon, D, Guttridge, M, Brown, J (2007) Directed sibling cord blood banking for transplantation: the 10-year experience in the national blood service in England. Stem Cells 25: pp. 2087-93 CrossRef
- Lauber, S, Latta, M, Kluter, H, Muller-Steinhardt, M (2010) The Mannheim cord blood bank: experiences and perspectives for the future. Transfus Med Hemother 37: pp. 90-7 CrossRef
- Bizzetto, R, Bonfim, C, Rocha, V (2011) Outcomes after related and unrelated umbilical cord blood transplantation for heredity bone marrow failure syndromes other than Fanconi anemia. Haematologica 96: pp. 134-41 CrossRef
- Cohen, YC, Scaradavou, A, Stevens, CE (2011) Factors affecting mortality following myeloablative cord blood transplantation in adults: a pooled analysis of three international registries. Bone Marrow Transplant 46: pp. 70-6 CrossRef
- Kurtzberg, J, Prasad, VK, Carter, SL (2008) Results of Cord Blood Transplantation Study (COBLT): clinical outcomes of unrelated donor umbilical cord blood transplantation in pediatric patients with hematologic malignancies. Blood 112: pp. 4318-27 CrossRef
- Eapen, M, Rocha, R, Sanz, G, Scaradavou, A, Zhang, M, Arcese, W (2010) Effect of graft source on unrelated donor haemopoietic stem-cell transplantation in adults with acute leukaemia: a retrospective analysis. Lancet Oncol 11: pp. 653-60 CrossRef
- Brunstein, CG, Miller, JS, Cao, Q (2011) Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics. Blood 117: pp. 1061-70 CrossRef
- Verneris, MR, Brunstein, CG, Barker, J, MacMillan, ML (2009) Relapse risk after umbilical cord blood transplantation: enhanced graft-versus-leukemia effect in recipients of 2 units. Blood 114: pp. 4293-99 CrossRef
- Johansen, KA, Schneider, JF, McCaffree, MA, Woods, GL (2008) Efforts of the United States’ National Marrow Donor Program and Registry to improve utilization and representation of minority donors. Transfus Med 18: pp. 250-59 CrossRef
- Moise, KJ (2005) Umbilical cord stem cells. Obstet Gynecol 106: pp. 1393-407 CrossRef
- Salfilippo JS, Barnhard Y, Bahceci E, Bayer-Zwirello L, Donnenfeld AE, Mason BA et al. Family cord blood banking: What you need to know? OBG Management (Suppl). Nov. 2007; S1-S8.
- Gluckman, E, Broxmeyer, HA, Auerbach, AD, Friedman, HS, Douglas, GW, Devergie, A (1989) Hematopoietic reconstitution in a patient with Fanconi’s anemia by means of umbilical-cord blood from an HLA-identical sibling. N Engl J Med 321: pp. 1174-78 CrossRef
- Rubinstein, P, Taylor, PE, Scaradavou, A, Adamson, JW, Migliaccio, G, Emanuel, D, Berkowitz, RL (1994) Unrelated placental blood for bone marrow reconstitution: organization of the placental blood program. Blood Cells 20: pp. 587-96
- Kurtzberg, J, Laughlin, M, Graham, ML, Smith, C, Olson, JF, Halperin, EC (1996) Placental blood as a source of hematopoietic stem cells for transplantation into unrelated recipients. N Engl J Med 335: pp. 157-66 CrossRef
- Rubinstein, P (2009) Cord blood banking for clinical transplantation. Bone Marrow Transplant 44: pp. 635-42 CrossRef
- Navarrete, C, Contreras, M (2009) Cord blood banking. A historical perspective. Br J Haematol. 147: pp. 236-45 CrossRef
- Garcia, J (2010) Allogeneic unrelated cord blood banking worldwide: an update. Transfus Apher Sci 42: pp. 257-63 CrossRef
- NETCORD-Fact: Internatioanal Standards for Cord Blood Collection, Processing, Testing, Banking, Selection and Release, 4th ed. Omaha, FACT, 2008. http://www.factwebsite.org/Standards/. Accessed January 7, 2011.
- Hollands, P, McCauley, C (2009) Private cord blood banking: current use and clinical future. Stem Cell Rev 5: pp. 195-03 CrossRef
- Ballen, KK, Barker, JN, Stewart, SK, Greene, MF, Lane, TA (2008) Collection and preservation of cord blood for personal use. Biol Blood Marrow Transplant 14: pp. 356-63 CrossRef
- Johnson, FL (1997) Placental blood transplantation and autologous banking–caveat emptor. J Pediatr Hematol Oncol 19: pp. 183-86 CrossRef
- Greaves, M (2003) Pre-natal origins of childhood leukemia. Rev Clin Exp Hematol 7: pp. 233-45
- Samuel, GN, Kerridge, IH, O’Brien, TA (2008) Umbilical cord blood banking: public good or private benefit?. Med J Aust 188: pp. 533-55
- Lubin, BH, Shearer, WT (2007) Cord blood banking for potential future tranpslantation. Pediatrics 119: pp. 165-70 CrossRef
- Sun, J, Allison, J, McLaughlin, C, Sledge, L, Waters-Pick, B, Wease, S (2010) Differences in quality between privately and publicly banked umbilical cord blood units: a pilot study of autologous cord blood infusion in children with acquired neurologic disorders. Transfusion 50: pp. 1980-87 CrossRef
- Yang, H, Loutfy, MR, Mayerhofer, S, Shuen, P (2011) Factors affecting banking quality of umbilical cord blood for transplantation. Transfusion 51: pp. 286-92 CrossRef
- Broxmeyer, HE, Srour, EF, Hangoc, G, Cooper, S, Anderson, SA, Bodine, DM (2003) High-efficiency recovery of functional hematopoietic progenitor and stem cells from human cord blood cryopreserved for 15 years. Proc Natl Acad Sci USA 100: pp. 645-50 CrossRef
- Reagan, DM, Wofford, JD, Wall, DA (2010) Comparison of cord blood thawing methods on cell recovery, potency, and infusion. Transfusion 50: pp. 2670-75 CrossRef
- Wofford, JD (2005) Adult transplant outcomes, single versus pooled blood transplants. Biol Blood Marrow Transplant 11: pp. 2 CrossRef
- Beatty, PG, Boucher, KM, Mori, M, Milford, EL (2000) Probability of finding HLA-mismatched related or unrelated marrow or cord blood donors. Hum Immunol 61: pp. 834-40 CrossRef
- Thornley, I, Eapen, M, Sung, L, Lee, SJ, Davies, SM, Joffe, S (2009) Private cord blood banking: experiences and views of pediatric hematopoietic cell transplantation physicians. Pediatrics 123: pp. 1011-17 CrossRef
- Vellodi, A (2005) Lysosomal storage disorders. Br J Haematol. 128: pp. 413-31 CrossRef
- Whitley, CB, Belani, KG, Chang, PN, Summers, CG, Blazar, BR, Tsai, MY (1993) Long-term outcome of Hurler syndrome following bone marrow transplantation. Am J Med Genet 46: pp. 209-18 CrossRef
- Peters, C, Shapiro, EG, Anderson, J, Henslee-Downey, PJ, Klemperer, MR, Cowan, MJ (1998) Hurler syndrome: II. Outcome of HLA-genotypically identical sibling and HLA-haploidentical related donor bone marrow transplantation in fifty-four children. The Storage Disease Collaborative Study Group. Blood 91: pp. 2601-08
- Peters, C, Charnas, LR, Tan, Y, Ziegler, RS, Shapiro, EG, DeFor, T (2004) Cerebral X-linked adrenoleukodystrophy: the international hematopoietic cell transplantation experience from 1982 to 1999. Blood 104: pp. 881-88 CrossRef
- Krivit, W, Pierpont, ME, Ayaz, K, Tsai, M, Ramsay, NK, Kersey, JH (1984) Bone-marrow transplantation in the Maroteaux-Lamy syndrome (mucopolysaccharidosis type VI). Biochemical and clinical status 24 months after transplantation. N Engl J Med 311: pp. 1606-11 CrossRef
- Prasad, VK, Kurtzberg, J (2008) Emerging trends in transplantation of inherited metabolic diseases. Bone Marrow Transplant 41: pp. 99-08 CrossRef
- McKenna, DH, Brunstein, CG (2011) Umbilical cord blood: current status and future directions. Vox Sang 100: pp. 150-62 CrossRef
- McGuckin, CP, Forraz, N, Baradez, MO, Navran, S, Zhao, J, Urban, R (2005) Production of stem cells with embryonic characteristics from human umbilical cord blood. Cell Prolif 38: pp. 245-55 CrossRef
- Sanchez-Ramos, JR (2002) Neural cells derived from adult bone marrow and umbilical cord blood. J Neurosci Res 69: pp. 880-93 CrossRef
- Newcomb, JD, Willing, AE, Sanberg, PR (2009) Umbilical cord blood cells. Meth Mol Biol 549: pp. 119-36 CrossRef
- Park, DH, Borlongan, CV, Willing, AE, Eve, DJ, Cruz, LE, Sanberg, CD (2009) Human umbilical cord blood cell grafts for brain ischemia. Cell Transplant 18: pp. 985-98 CrossRef
- Copeland, N, Harris, D, Gaballa, MA (2009) Human umbilical cord blood stem cells, myocardial infarction and stroke. Clin Med 9: pp. 342-45
- Sanberg PR, Eve DJ, Willing AE, Garbuzova-Davis S, Tan J, Sanberg CD et al. The treatment of neurodegenerative disorders using umbilical cord blood and menstrual blood-derived stem cells. Cell Transplant. 2010; Sep 30 [Epub ahead of print].
- Chen, J, Sanberg, PR, Li, Y, Wang, L, Lu, M, Willing, AE (2001) Intravenous administration of human umbilical cord blood reduces behavioral deficits after stroke in rats. Stroke 32: pp. 2682-88 CrossRef
- Ende, N, Chen, R (2002) Parkinson’s disease mice and human umbilical cord blood. J Med 33: pp. 173-80
- Ende, N, Chen, R, Ende-Harris, D (2001) Human umbilical cord blood cells ameliorate Alzheimer’s disease in transgenic mice. J Med 32: pp. 241-47
- Ende, N, Chen, R (2001) Human umbilical cord blood cells ameliorate Huntington’s disease in transgenic mice. J Med 32: pp. 231-40
- Chen, R, Ende, N (2000) The potential for the use of mononuclear cells from human umbilical cord blood in the treatment of amyotrophic lateral sclerosis in SOD1 mice. J Med 31: pp. 21-30
- Campli, C, Piscaglia, AC, Pierelli, L, Rutella, S, Bonanno, G, Alison, MR (2004) A human umbilical cord stem cell rescue therapy in a murine model of toxic liver injury. Dig Liver Dis 36: pp. 603-13 CrossRef
- Ende, N, Chen, R, Reddi, AS (2004) Effect of human umbilical cord blood cells on glycemia and insulitis in type1diabetic mice. Biochem Biophys Res Commun 325: pp. 665-69 CrossRef
- Zhao, Y, Mazzone, T (2010) Human cord blood stem cells and the journey to a cure for type 1 diabetes. Autoimmun Rev 10: pp. 103-07 CrossRef
- Amado, LC, Saliaris, AP, Schuleri, KH, St John, M, Xie, JS, Cattaneo, S (2005) Cardiac repair with intramyocardial injection of allogeneic mesenchymal stem cells after myocardial infarction. Proc Natl Acad Sci USA 102: pp. 11474-79 CrossRef
- Arien-Zakay H, Lazarovici P, Nagler A. Tissue regeneration potential in human umbilical cord blood. 2010;23:291–303.
- Forraz N, McGuckin CP. The umbilical cord: a rich and ethical stem cell source to advance regenerative medicine. 2011;44(Suppl 1):66–9.
- US National Institues of Health. Umbilical cord blood infusion to treat type 1 diabetes. http://www.clinicaltrials.gov/ct2/search, NCT0030544. Accessed January 7, 2011.
- National Guidelines Clearing House. Cord blood banking for potential future transplantation. http://www.guidelines.gov/content.aspx?id=10389. Accessed January 7, 2011.
- Umbilical cord blood banking: an update
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