Umbilical cord blood banking: an update
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.Get Access
Umbilical cord blood is a potential vast source of primitive hematopoietic stem and progenitor cells available for clinical application to reconstitute the hematopoietic system and/or restore immunological function in affected individuals requiring treatment. Cord blood can be used as an alternative source for bone marrow transplantation and its use is developing into a new field of treatment for pediatric and adult patients presenting with hematological disorders, immunological defects and specific genetic diseases.
More than 25,000 allogeneic cord blood transplantations have been performed worldwide since the first cord blood transplantation in 1988. There are two banking options for storing umbilical cord blood [private (family) and public]. Cord blood stored in private banks are used for either autologous or allogeneic transplants for the infant donor or related family members but private cord blood banks are not searchable or available to the public. More than 780,000 cord blood units are stored in over 130 private cord blood banks, worldwide, and over 400,000 units in more than 100 quality controlled public cord blood banks.
Researchers continue to evaluate the usefulness of cord blood cells in treating human diseases or disorders for purposes other than hematological disorders including heart disease, strokes, brain or spinal cord injuries and cancer. This review summarizes the status of umbilical cord blood banking, its history and current and potential use in the treatment of human disease.
- Hwang WY, Samuel M, Tan D, Koh LP, Lim W, Linn YC. A meta-analysis of unrelated donor umbilical cord blood transplantation versus unrelated donor bone marrow transplantation in adult and pediatric patients. Biol Blood Marrow Transplant. 2007;13:444–53. CrossRef
- Frangoul H, Wang L, Harrell Jr FE, Manes B, Calder C, Domm J. Unrelated umbilical cord blood transplantation in children with immune deficiency: results of a multicenter study. Bone Marrow Transplant. 2010;45:283–8. CrossRef
- Prasad VK, Mendizabal A, Parikh SH, Szabolcs P, Driscoll TA, Page K, et al. Unrelated donor umbilical cord blood transplantation for inherited metabolic disorders in 159 pediatric patients from a single center: influence of cellular composition of the graft on transplantation outcomes. Blood. 2008;112:2979–89. CrossRef
- Eapen M, Rubinstein P, Zhang MJ, Stevens C, Kurtzberg J, Scaradavou A, et al. Outcomes of transplantation of unrelated donor umbilical cord blood and bone marrow in children with acute leukaemia: a comparison study. Lancet. 2007;369:1947–54. CrossRef
- Laughlin MJ, Eapen M, Rubinstein P, Wagner JE, Zhang MJ, Champlin RE, et al. Outcomes after transplantation of cord blood or bone marrow from unrelated donors in adults with leukemia. N Engl J Med. 2004;351:2265–75. CrossRef
- Wagner JE, Barker JN, DeFor TE, Baker KS, Blazar BR, Eide C, et al. Transplantation of unrelated donor umbilical cord blood in 102 patients with malignant and nonmalignant diseases: influence of CD34 cell dose and HLA disparity on treatment-related mortality and survival. Blood. 2002;100:1611–18.
- Smythe J, Armitage S, McDonald D, Pamphilon D, Guttridge M, Brown J, et al. Directed sibling cord blood banking for transplantation: the 10-year experience in the national blood service in England. Stem Cells. 2007;25:2087–93. CrossRef
- Lauber S, Latta M, Kluter H, Muller-Steinhardt M. The Mannheim cord blood bank: experiences and perspectives for the future. Transfus Med Hemother. 2010;37:90–7. CrossRef
- Bizzetto R, Bonfim C, Rocha V. Outcomes after related and unrelated umbilical cord blood transplantation for heredity bone marrow failure syndromes other than Fanconi anemia. Haematologica. 2011;96:134–41. CrossRef
- Cohen YC, Scaradavou A, Stevens CE. Factors affecting mortality following myeloablative cord blood transplantation in adults: a pooled analysis of three international registries. Bone Marrow Transplant. 2011;46:70–6. CrossRef
- Kurtzberg J, Prasad VK, Carter SL. Results of Cord Blood Transplantation Study (COBLT): clinical outcomes of unrelated donor umbilical cord blood transplantation in pediatric patients with hematologic malignancies. Blood. 2008;112:4318–27. CrossRef
- Eapen M, Rocha R, Sanz G, Scaradavou A, Zhang M, Arcese W, et al. Effect of graft source on unrelated donor haemopoietic stem-cell transplantation in adults with acute leukaemia: a retrospective analysis. Lancet Oncol. 2010;11:653–60. CrossRef
- Brunstein CG, Miller JS, Cao Q. Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics. Blood. 2011;117:1061–70. CrossRef
- Verneris MR, Brunstein CG, Barker J, MacMillan ML. Relapse risk after umbilical cord blood transplantation: enhanced graft-versus-leukemia effect in recipients of 2 units. Blood. 2009;114:4293–99. CrossRef
- Johansen KA, Schneider JF, McCaffree MA, Woods GL. Efforts of the United States’ National Marrow Donor Program and Registry to improve utilization and representation of minority donors. Transfus Med. 2008;18:250–59. CrossRef
- Moise Jr KJ. Umbilical cord stem cells. Obstet Gynecol. 2005;106:1393–407. CrossRef
- Salfilippo JS, Barnhard Y, Bahceci E, Bayer-Zwirello L, Donnenfeld AE, Mason BA et al. Family cord blood banking: What you need to know? OBG Management (Suppl). Nov. 2007; S1-S8.
- Gluckman E, Broxmeyer HA, Auerbach AD, Friedman HS, Douglas GW, Devergie A, et al. Hematopoietic reconstitution in a patient with Fanconi’s anemia by means of umbilical-cord blood from an HLA-identical sibling. N Engl J Med. 1989;321:1174–78. CrossRef
- Rubinstein P, Taylor PE, Scaradavou A, Adamson JW, Migliaccio G, Emanuel D, et al. Unrelated placental blood for bone marrow reconstitution: organization of the placental blood program. Blood Cells. 1994;20:587–96.
- Kurtzberg J, Laughlin M, Graham ML, Smith C, Olson JF, Halperin EC, et al. Placental blood as a source of hematopoietic stem cells for transplantation into unrelated recipients. N Engl J Med. 1996;335:157–66. CrossRef
- Rubinstein P. Cord blood banking for clinical transplantation. Bone Marrow Transplant. 2009;44:635–42. CrossRef
- Navarrete C, Contreras M. Cord blood banking. A historical perspective. Br J Haematol. 2009;147:236–45. CrossRef
- Garcia J. Allogeneic unrelated cord blood banking worldwide: an update. Transfus Apher Sci. 2010;42:257–63. CrossRef
- NETCORD-Fact: Internatioanal Standards for Cord Blood Collection, Processing, Testing, Banking, Selection and Release, 4th ed. Omaha, FACT, 2008. http://www.factwebsite.org/Standards/. Accessed January 7, 2011.
- Hollands P, McCauley C. Private cord blood banking: current use and clinical future. Stem Cell Rev. 2009;5:195–03. CrossRef
- Ballen KK, Barker JN, Stewart SK, Greene MF, Lane TA. Collection and preservation of cord blood for personal use. Biol Blood Marrow Transplant. 2008;14:356–63. CrossRef
- Johnson FL. Placental blood transplantation and autologous banking–caveat emptor. J Pediatr Hematol Oncol. 1997;19:183–86. CrossRef
- Greaves M. Pre-natal origins of childhood leukemia. Rev Clin Exp Hematol. 2003;7:233–45.
- Samuel GN, Kerridge IH, O’Brien TA. Umbilical cord blood banking: public good or private benefit? Med J Aust. 2008;188:533–55.
- American Academy of Pediatrics Secton on Hematology/Oncology, American Academy of Pediatrics Section on Allergy/Immunology, Lubin BH, Shearer WT. Cord blood banking for potential future tranpslantation. Pediatrics. 2007;119:165–70. CrossRef
- Sun J, Allison J, McLaughlin C, Sledge L, Waters-Pick B, Wease S, et al. Differences in quality between privately and publicly banked umbilical cord blood units: a pilot study of autologous cord blood infusion in children with acquired neurologic disorders. Transfusion. 2010;50:1980–87. CrossRef
- Yang H, Loutfy MR, Mayerhofer S, Shuen P. Factors affecting banking quality of umbilical cord blood for transplantation. Transfusion. 2011;51:286–92. CrossRef
- Broxmeyer HE, Srour EF, Hangoc G, Cooper S, Anderson SA, Bodine DM. High-efficiency recovery of functional hematopoietic progenitor and stem cells from human cord blood cryopreserved for 15 years. Proc Natl Acad Sci USA. 2003;100:645–50. CrossRef
- Reagan DM, Wofford JD, Wall DA. Comparison of cord blood thawing methods on cell recovery, potency, and infusion. Transfusion. 2010;50:2670–75. CrossRef
- Wofford JD. Adult transplant outcomes, single versus pooled blood transplants. Biol Blood Marrow Transplant. 2005;11(Suppl1):2. CrossRef
- Beatty PG, Boucher KM, Mori M, Milford EL. Probability of finding HLA-mismatched related or unrelated marrow or cord blood donors. Hum Immunol. 2000;61:834–40. CrossRef
- Thornley I, Eapen M, Sung L, Lee SJ, Davies SM, Joffe S. Private cord blood banking: experiences and views of pediatric hematopoietic cell transplantation physicians. Pediatrics. 2009;123:1011–17. CrossRef
- Vellodi A. Lysosomal storage disorders. Br J Haematol. 2005;128:413–31. CrossRef
- Whitley CB, Belani KG, Chang PN, Summers CG, Blazar BR, Tsai MY, et al. Long-term outcome of Hurler syndrome following bone marrow transplantation. Am J Med Genet. 1993;46:209–18. CrossRef
- Peters C, Shapiro EG, Anderson J, Henslee-Downey PJ, Klemperer MR, Cowan MJ, et al. Hurler syndrome: II. Outcome of HLA-genotypically identical sibling and HLA-haploidentical related donor bone marrow transplantation in fifty-four children. The Storage Disease Collaborative Study Group. Blood. 1998;91:2601–08.
- Peters C, Charnas LR, Tan Y, Ziegler RS, Shapiro EG, DeFor T, et al. Cerebral X-linked adrenoleukodystrophy: the international hematopoietic cell transplantation experience from 1982 to 1999. Blood. 2004;104:881–88. CrossRef
- Krivit W, Pierpont ME, Ayaz K, Tsai M, Ramsay NK, Kersey JH, et al. Bone-marrow transplantation in the Maroteaux-Lamy syndrome (mucopolysaccharidosis type VI). Biochemical and clinical status 24 months after transplantation. N Engl J Med. 1984;311:1606–11. CrossRef
- Prasad VK, Kurtzberg J. Emerging trends in transplantation of inherited metabolic diseases. Bone Marrow Transplant. 2008;41:99–08. CrossRef
- McKenna DH, Brunstein CG. Umbilical cord blood: current status and future directions. Vox Sang. 2011;100:150–62. CrossRef
- McGuckin CP, Forraz N, Baradez MO, Navran S, Zhao J, Urban R, et al. Production of stem cells with embryonic characteristics from human umbilical cord blood. Cell Prolif. 2005;38:245–55. CrossRef
- Sanchez-Ramos JR. Neural cells derived from adult bone marrow and umbilical cord blood. J Neurosci Res. 2002;69:880–93. CrossRef
- Newcomb JD, Willing AE, Sanberg PR. Umbilical cord blood cells. Meth Mol Biol. 2009;549:119–36. CrossRef
- Park DH, Borlongan CV, Willing AE, Eve DJ, Cruz LE, Sanberg CD, et al. Human umbilical cord blood cell grafts for brain ischemia. Cell Transplant. 2009;18:985–98. CrossRef
- Copeland N, Harris D, Gaballa MA. Human umbilical cord blood stem cells, myocardial infarction and stroke. Clin Med. 2009;9:342–45.
- Sanberg PR, Eve DJ, Willing AE, Garbuzova-Davis S, Tan J, Sanberg CD et al. The treatment of neurodegenerative disorders using umbilical cord blood and menstrual blood-derived stem cells. Cell Transplant. 2010; Sep 30 [Epub ahead of print].
- Chen J, Sanberg PR, Li Y, Wang L, Lu M, Willing AE, et al. Intravenous administration of human umbilical cord blood reduces behavioral deficits after stroke in rats. Stroke. 2001;32:2682–88. CrossRef
- Ende N, Chen R. Parkinson’s disease mice and human umbilical cord blood. J Med. 2002;33:173–80.
- Ende N, Chen R, Ende-Harris D. Human umbilical cord blood cells ameliorate Alzheimer’s disease in transgenic mice. J Med. 2001;32:241–47.
- Ende N, Chen R. Human umbilical cord blood cells ameliorate Huntington’s disease in transgenic mice. J Med. 2001;32:231–40.
- Chen R, Ende N. The potential for the use of mononuclear cells from human umbilical cord blood in the treatment of amyotrophic lateral sclerosis in SOD1 mice. J Med. 2000;31:21–30.
- Di Campli C, Piscaglia AC, Pierelli L, Rutella S, Bonanno G, Alison MR, et al. A human umbilical cord stem cell rescue therapy in a murine model of toxic liver injury. Dig Liver Dis. 2004;36:603–13. CrossRef
- Ende N, Chen R, Reddi AS. Effect of human umbilical cord blood cells on glycemia and insulitis in type1diabetic mice. Biochem Biophys Res Commun. 2004;325:665–69. CrossRef
- Zhao Y, Mazzone T. Human cord blood stem cells and the journey to a cure for type 1 diabetes. Autoimmun Rev. 2010;10:103–07. CrossRef
- Amado LC, Saliaris AP, Schuleri KH, St John M, Xie JS, Cattaneo S, et al. Cardiac repair with intramyocardial injection of allogeneic mesenchymal stem cells after myocardial infarction. Proc Natl Acad Sci USA. 2005;102:11474–79. CrossRef
- Arien-Zakay H, Lazarovici P, Nagler A. Tissue regeneration potential in human umbilical cord blood. 2010;23:291–303.
- Forraz N, McGuckin CP. The umbilical cord: a rich and ethical stem cell source to advance regenerative medicine. 2011;44(Suppl 1):66–9.
- US National Institues of Health. Umbilical cord blood infusion to treat type 1 diabetes. http://www.clinicaltrials.gov/ct2/search, NCT0030544. Accessed January 7, 2011.
- National Guidelines Clearing House. Cord blood banking for potential future transplantation. http://www.guidelines.gov/content.aspx?id=10389. Accessed January 7, 2011.
- Umbilical cord blood banking: an update
Journal of Assisted Reproduction and Genetics
Volume 28, Issue 8 , pp 669-676
- Cover Date
- Print ISSN
- Online ISSN
- Springer US
- Additional Links
- Umbilical cord blood
- Public and private cord blood banks
- Clinical applications
- Regenerative medicine
- Industry Sectors