What is the role of regulatory T cells in the success of implantation and early pregnancy?
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.Get Access
The immune system is well controlled by the balance between immunostimulation and immunoregulation. CD4+CD25+ regulatory T (Treg) cells and an enzyme called indoleamine-2, 3-dioxygenase (IDO) mediate maternal tolerance of the allogeneic fetus. Treg cells, therefore, may prevent early pregnancy loss due to maternal ‘rejection.’
The latest understanding of tolerance during pregnancy is reviewed.
Results and conclusions
Recent data show that CD4+CD25+ Treg cells play essential roles in the induction and maintenance of tolerance, and that they augment the IDO activity in dendritic cells and macrophages. Therefore, CD4+CD25+ Treg cells and IDO enzyme may cooperate in the induction of tolerance during pregnancy. Treg deficiency is associated with very early post-implantation loss and spontaneous abortion in animal models, and low Treg levels are associated with recurrent miscarriages in humans.
- What is the role of regulatory T cells in the success of implantation and early pregnancy?
Journal of Assisted Reproduction and Genetics
Volume 24, Issue 9 , pp 379-386
- Cover Date
- Print ISSN
- Online ISSN
- Springer US
- Additional Links
- CD4+CD25+ regulatory T cell
- Industry Sectors
- Author Affiliations
- 1. Department of Obstetrics and Gynecology, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan
- 2. Center of Excellence (COE) 21st Program, Morioka, Japan