Skip to main content
Log in

Cognitive Enhancement Therapy for Adults with Autism Spectrum Disorder: Results of an 18-month Feasibility Study

  • Original Paper
  • Published:
Journal of Autism and Developmental Disorders Aims and scope Submit manuscript

Abstract

Adults with autism experience significant impairments in social and non-social information processing for which few treatments have been developed. This study conducted an 18-month uncontrolled trial of Cognitive Enhancement Therapy (CET), a comprehensive cognitive rehabilitation intervention, in 14 verbal adults with autism spectrum disorder to investigate its feasibility, acceptability, and initial efficacy in treating these impairments. Results indicated that CET was satisfying to participants, with high treatment attendance and retention. Effects on cognitive deficits and social behavior were also large (d = 1.40–2.29) and statistically significant (all p < .001). These findings suggest that CET is a feasible, acceptable, and potentially effective intervention for remediating the social and non-social cognitive impairments in verbal adults with autism.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

Similar content being viewed by others

References

  • American Psychiatric Association. (2000). Diagnostic and statistical manual of mental disorders (4th ed.). Washington, DC: Author.

    Google Scholar 

  • Baron-Cohen, S. (1990). Autism: A specific cognitive disorder of ‘mind-blindness’. International Review of Psychiatry, 2(1), 81–90.

    Article  Google Scholar 

  • Ben-Yishay, Y., Piasetsky, E. B., & Rattok, J. (1985). A systematic method for ameliorating disorders in basic attention. In M. J. Meir, A. L. Benton, & L. Diller (Eds.), Neuropsychological rehabilitation (pp. 165–181). New York: Guilford Press.

    Google Scholar 

  • Berger, H. J. C., Aerts, F. H. T. M., van Spaendonck, K. P. M., Cools, A. R., & Teunisse, J. P. (2003). Central coherence and cognitive shifting in relation to social improvement in high-functioning young adults with autism. Journal of Clinical and Experimental Neuropsychology, 25(4), 502–511.

    Article  PubMed  Google Scholar 

  • Bracy, O. L. (1994). PSSCogRehab [computer software]. Indianapolis, IN: Psychological Software Services Inc.

    Google Scholar 

  • Cicerone, K. D., Dahlberg, C., Malec, J. F., Langenbahn, D. M., Felicetti, T., Kneipp, S., et al. (2005). Evidence-based cognitive rehabilitation: Updated review of the literature from 1998 through 2002. Archives of Physical Medicine and Rehabilitation, 86(8), 1681–1692.

    Article  PubMed  Google Scholar 

  • Couture, S. M., Penn, D. L., Losh, M., Adolphs, R., Hurley, R., & Piven, J. (2010). Comparison of social cognitive functioning in schizophrenia and high functioning autism: more convergence than divergence. Psychological Medicine, 40(4), 569–579.

    Article  PubMed  Google Scholar 

  • Dawson, G., Rogers, S., Munson, J., Smith, M., Winter, J., Greenson, J., et al. (2010). Randomized, controlled trial of an intervention for toddlers with autism: The Early Start Denver Model. Pediatrics, 125(1), e17.

    Article  PubMed  Google Scholar 

  • Dempster, A. P., Laird, N. M., & Rubin, D. B. (1977). Maximum likelihood from incomplete data using the EM algorithm. Journal of the Royal Statistical Society: Series B (Methodological), 39(1), 1–38.

    Google Scholar 

  • Eack, S. M. (2012). Cognitive remediation: A new generation of psychosocial interventions for people with schizophrenia. Social Work, 57(3), 235–246.

    Article  PubMed  Google Scholar 

  • Eack, S. M., Greenwald, D. P., Hogarty, S. S., Cooley, S. J., DiBarry, A. L., Montrose, D. M., et al. (2009). Cognitive Enhancement Therapy for early-course schizophrenia: Effects of a 2-year randomized controlled trial. Psychiatric Services, 60(11), 1468–1476.

    Article  PubMed  Google Scholar 

  • Eack, S. M., Greenwald, D. P., Hogarty, S. S., & Keshavan, M. S. (2010a). One-year durability of the effects of Cognitive Enhancement Therapy on functional outcome in early schizophrenia. Schizophrenia Research, 120(1), 210–216.

    Article  PubMed  Google Scholar 

  • Eack, S. M., Hogarty, G. E., Cho, R. Y., Prasad, K. M. R., Greenwald, D. P., Hogarty, S. S., et al. (2010b). Neuroprotective effects of Cognitive Enhancement Therapy against gray matter loss in early schizophrenia: Results from a 2-year randomized controlled trial. Archives of General Psychiatry, 67(7), 674–682.

    Article  PubMed  Google Scholar 

  • Eack, S. M., Hogarty, G. E., Greenwald, D. P., Hogarty, S. S., & Keshavan, M. S. (2011). Effects of Cognitive Enhancement Therapy on employment outcomes in early schizophrenia: Results from a 2-year randomized trial. Research on Social Work Practice, 21(3), 32–42.

    Article  PubMed  Google Scholar 

  • Fitzpatrick, L. B., Minshew, N. J., & Eack, S. M. (2013). A systematic review of psychosocial interventions for adults with autism spectrum disorders. Journal of Autism and Developmental Disorders, 43(3), 687–694.

    Google Scholar 

  • Ganz, M. L. (2007). The lifetime distribution of the incremental societal costs of autism. Archives of Pediatrics and Adolescent Medicine, 161(4), 343–349.

    Article  PubMed  Google Scholar 

  • García-Villamisar, D., Rojahn, J., Zaja, R. H., & Jodra, M. (2010). Facial emotion processing and social adaptation in adults with and without autism spectrum disorder. Research in Autism Spectrum Disorders, 4(4), 755–762.

    Article  Google Scholar 

  • Gilotty, L., Kenworthy, L., Sirian, L., Black, D. O., & Wagner, A. E. (2002). Adaptive skills and executive function in autism spectrum disorders. Child Neuropsychology, 8(4), 241–248.

    Article  PubMed  Google Scholar 

  • Goldstein, G., Minshew, N. J., Allen, D. N., & Seaton, B. E. (2002). High-functioning autism and schizophrenia A comparison of an early and late onset neurodevelopmental disorder. Archives of Clinical Neuropsychology, 17(5), 461–475.

    PubMed  Google Scholar 

  • Green, M. F., Nuechterlein, K. H., Gold, J. M., Barch, D. M., Cohen, J., Essock, S., et al. (2004). Approaching a consensus cognitive battery for clinical trials in schizophrenia: The NIMH-MATRICS conference to select cognitive domains and test criteria. Biological Psychiatry, 56(5), 301–307.

    Article  PubMed  Google Scholar 

  • Guilmatre, A., Dubourg, C., Mosca, A. L., Legallic, S., Goldenberg, A., Drouin-Garraud, V., et al. (2009). Recurrent rearrangements in synaptic and neurodevelopmental genes and shared biologic pathways in schizophrenia, autism, and mental retardation. Archives of General Psychiatry, 66(9), 947–956.

    Article  PubMed  Google Scholar 

  • Gur, R. C., Schroeder, L., Turner, T., McGrath, C., Chan, R. M., Turetsky, B. I., et al. (2002). Brain activation during facial emotion processing. Neuroimage, 16(PA3), 651–662.

    Article  PubMed  Google Scholar 

  • Heaton, R. K., Chelune, G. J., Talley, J. L., Kay, G. G., & Curtiss, G. (1993). Wisconsin card sorting test manual: Revised and expanded. Odessa, FL: Psychological Assessment Resources Inc.

    Google Scholar 

  • Hobson, R. P., Ouston, J., & Lee, A. (1988). Emotion recognition in autism: coordinating faces and voices. Psychological Medicine, 18(4), 911–923.

    Article  PubMed  Google Scholar 

  • Hogarty, G. E., Flesher, S., Ulrich, R., Carter, M., Greenwald, D., Pogue-Geile, M., et al. (2004). Cognitive enhancement therapy for schizophrenia. Effects of a 2-year randomized trial on cognition and behavior. Archives of General Psychiatry, 61(9), 866–876.

    Article  PubMed  Google Scholar 

  • Hogarty, G. E., & Greenwald, D. P. (2006). Cognitive Enhancement Therapy: The training manual. University of Pittsburgh Medical Center: Authors. Available through www.CognitiveEnhancementTherapy.com.

  • Hogarty, G. E., Greenwald, D. P., & Eack, S. M. (2006). Durability and mechanism of effects of Cognitive Enhancement Therapy. Psychiatric Services, 57(12), 1751–1757.

    Article  PubMed  Google Scholar 

  • Howlin, P., Goode, S., Hutton, J., & Rutter, M. (2004). Adult outcome for children with autism. Journal of Child Psychology and Psychiatry, 45(2), 212–229.

    Article  PubMed  Google Scholar 

  • Hughes, C., Russell, J., & Robbins, T. W. (1994). Evidence for executive dysfunction in autism. Neuropsychologia, 32(4), 477–492.

    Article  PubMed  Google Scholar 

  • Kanner, L., Rodriguez, A., & Ashenden, B. (1972). How far can autistic children go in matters of social adaptation? Journal of Autism and Developmental Disorders, 2(1), 9–33.

    Article  Google Scholar 

  • Kasari, C., & Lawton, K. (2010). New directions in behavioral treatment of autism spectrum disorders. Current Opinion in Neurology, 23(2), 137–143.

    Article  PubMed  Google Scholar 

  • Kohler, C. G., Turner, T. H., Bilker, W. B., Brensinger, C. M., Siegel, S. J., Kanes, S. J., et al. (2003). Facial emotion recognition in schizophrenia: Intensity effects and error pattern. American Journal of Psychiatry, 160, 1768–1774.

    Article  PubMed  Google Scholar 

  • Larsen, D. L., Attkisson, C. C., Hargreaves, W. A., & Nguyen, T. D. (1979). Assessment of client/patient satisfaction: Development of a general scale. Evaluation and Program Planning, 2(3), 197–207.

    Article  PubMed  Google Scholar 

  • Lord, C., Risi, S., Lambrecht, L., Cook, E. H., Leventhal, B. L., DiLavore, P. C., et al. (2000). The autism diagnostic observation schedule—generic: A standard measure of social and communication deficits associated with the spectrum of autism. Journal of Autism and Developmental Disorders, 30(3), 205–223.

    Article  PubMed  Google Scholar 

  • Lord, C., Rutter, M., & Couteur, A. (1994). Autism diagnostic interview-revised: A revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. Journal of Autism and Developmental Disorders, 24(5), 659–685.

    Article  PubMed  Google Scholar 

  • Mayer, J. D., Salovey, P., Caruso, D. R., & Sitarenios, G. (2003). Measuring emotional intelligence with the MSCEIT V2.0. Emotion, 3(1), 97–105.

    Article  PubMed  Google Scholar 

  • Mayes, S. D., & Calhoun, S. L. (2007). Learning, attention, writing, and processing speed in typical children and children with ADHD, autism, anxiety, depression, and oppositional-defiant disorder. Child Neuropsychology, 13(6), 469–493.

    Article  PubMed  Google Scholar 

  • Minshew, N. J., Goldstein, G., & Siegel, D. J. (1997). Neuropsychologic functioning in autism: Profile of a complex information processing disorder. Journal of the International Neuropsychological Society, 3(4), 303–316.

    PubMed  Google Scholar 

  • Minshew, N. J., & Williams, D. L. (2007). The new neurobiology of autism. Archives of Neurology, 64(7), 945–950.

    Article  PubMed  Google Scholar 

  • Mizuno, A., Liu, Y., Williams, D. L., Keller, T. A., Minshew, N. J., & Just, M. A. (2011). The neural basis of deictic shifting in linguistic perspective-taking in high-functioning autism. Brain, 134(8), 2422–2435.

    Article  PubMed  Google Scholar 

  • Olazaran, J., Muniz, R., Reisberg, B., Pena-Casanova, J., del Ser, T., Cruz-Jentoft, A. J., et al. (2004). Benefits of cognitive-motor intervention in MCI and mild to moderate Alzheimer disease. Neurology, 63(12), 2348–2353.

    Article  PubMed  Google Scholar 

  • Ozonoff, S. (1995). Executive functions in autism. In E. Schopler & G. B. Mesibov (Eds.), Learning and cognition in autism (pp. 3–27). New York: Plenum Press.

    Google Scholar 

  • Penn, D. L., Corrigan, P. W., Bentall, R. P., Racenstein, J., & Newman, L. (1997). Social cognition in schizophrenia. Psychological Bulletin, 121(1), 114–132.

    Article  PubMed  Google Scholar 

  • Pilowsky, T., Yirmiya, N., Arbelle, S., & Mozes, T. (2000). Theory of mind abilities of children with schizophrenia, children with autism, and normally developing children. Schizophrenia Research, 42(2), 145–155.

    Article  PubMed  Google Scholar 

  • Pinkham, A. E., Hopfinger, J. B., Pelphrey, K. A., Piven, J., & Penn, D. L. (2007). Neural bases for impaired social cognition in schizophrenia and autism spectrum disorders. Schizophrenia Research, 99(1–3), 164–175.

    PubMed  Google Scholar 

  • Rapp, S., Brenes, G., & Marsh, A. P. (2002). Memory enhancement training for older adults with mild cognitive impairment: a preliminary study. Aging and Mental Health, 6(1), 5–11.

    Article  PubMed  Google Scholar 

  • Raudenbush, D. S. W., & Bryk, D. A. S. (2002). Hierarchical linear models: Applications and data analysis methods. Thousand Oaks, CA: Sage.

    Google Scholar 

  • Samson, A. C., Huber, O., & Gross, J. J. (2012). Emotion regulation in Asperger’s syndrome and high-functioning autism. Emotion, 12(4), 659–665.

    Article  PubMed  Google Scholar 

  • Sasson, N., Tsuchiya, N., Hurley, R., Couture, S. M., Penn, D. L., Adolphs, R., et al. (2007). Orienting to social stimuli differentiates social cognitive impairment in autism and schizophrenia. Neuropsychologia, 45(11), 2580–2588.

    Article  PubMed  Google Scholar 

  • Schneider, S. G., & Asarnow, R. F. (1987). A comparison of cognitive/neuropsychological impairments of nonretarded autistic and schizophrenic children. Journal of Abnormal Child Psychology, 15(1), 29–45.

    Article  PubMed  Google Scholar 

  • Selman, R. L., & Schultz, L. H. (1990). Making a friend in youth. Chicago, IL: University of Chicago Press.

    Google Scholar 

  • Sergi, M. J., Rassovsky, Y., Nuechterlein, K. H., & Green, M. F. (2006). Social perception as a mediator of the influence of early visual processing on functional status in schizophrenia. American Journal of Psychiatry, 163(3), 448–454.

    Article  PubMed  Google Scholar 

  • Shattuck, P. T., Wagner, M., Narendorf, S., Sterzing, P., & Hensley, M. (2011). Post-high school service use among young adults with an autism spectrum disorder. Archives of Pediatrics and Adolescent Medicine, 165(2), 141–146.

    Article  PubMed  Google Scholar 

  • Simon, H. A. (1979). Information processing models of cognition. Annual Review of Psychology, 30(1), 363–396.

    Article  PubMed  Google Scholar 

  • Sugranyes, G., Kyriakopoulos, M., Corrigall, R., Taylor, E., & Frangou, S. (2011). Autism spectrum disorders and schizophrenia: Meta-analysis of the neural correlates of social cognition. PLoS ONE, 6(10), e25322.

    Article  PubMed  Google Scholar 

  • Temple, E., Deutsch, G. K., Poldrack, R. A., Miller, S. L., Tallal, P., Merzenich, M. M., et al. (2003). Neural deficits in children with dyslexia ameliorated by behavioral remediation: Evidence from functional MRI. Proceedings of the National Academy of Sciences, 100(5), 2860–2865.

    Article  Google Scholar 

  • Volkmar, F. R., Lord, C., Bailey, A., Schultz, R. T., & Klin, A. (2004). Autism and pervasive developmental disorders. Journal of Child Psychology and Psychiatry, 45(1), 135–170.

    Article  PubMed  Google Scholar 

  • Wang, A. T., Lee, S. S., Sigman, M., & Dapretto, M. (2006). Neural basis of irony comprehension in children with autism: the role of prosody and context. Brain, 129(4), 932–943.

    Article  PubMed  Google Scholar 

  • Wechsler, D. (1999). Manual for the Wechsler abbreviated intelligence scale. San Antonio, TX: The Psychological Corporation.

    Google Scholar 

  • Williams, D. L., Goldstein, G., Carpenter, P. A., & Minshew, N. J. (2005). Verbal and spatial working memory in autism. Journal of Autism and Developmental Disorders, 35(6), 747–756.

    Article  PubMed  Google Scholar 

  • Wykes, T., Huddy, V., Cellard, C., McGurk, S. R., & Czobor, P. (2011). A meta-analysis of cognitive remediation for schizophrenia: Methodology and effect sizes. American Journal of Psychiatry, 168(5), 472–485.

    Article  PubMed  Google Scholar 

Download references

Acknowledgments

This work was supported by NIH grants MH-85851 (NJM and SME), RR-24154 (SME), MH-95783 (SME) and HD-55748 (NJM), as well as grants from Autism Speaks (NJM and SME), the Department of Defense (NJM and SME), and the Pennsylvania Department of Health (NJM).

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Shaun M. Eack.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Eack, S.M., Greenwald, D.P., Hogarty, S.S. et al. Cognitive Enhancement Therapy for Adults with Autism Spectrum Disorder: Results of an 18-month Feasibility Study. J Autism Dev Disord 43, 2866–2877 (2013). https://doi.org/10.1007/s10803-013-1834-7

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10803-013-1834-7

Keywords

Navigation