Abstract
Adults with autism experience significant impairments in social and non-social information processing for which few treatments have been developed. This study conducted an 18-month uncontrolled trial of Cognitive Enhancement Therapy (CET), a comprehensive cognitive rehabilitation intervention, in 14 verbal adults with autism spectrum disorder to investigate its feasibility, acceptability, and initial efficacy in treating these impairments. Results indicated that CET was satisfying to participants, with high treatment attendance and retention. Effects on cognitive deficits and social behavior were also large (d = 1.40–2.29) and statistically significant (all p < .001). These findings suggest that CET is a feasible, acceptable, and potentially effective intervention for remediating the social and non-social cognitive impairments in verbal adults with autism.
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References
American Psychiatric Association. (2000). Diagnostic and statistical manual of mental disorders (4th ed.). Washington, DC: Author.
Baron-Cohen, S. (1990). Autism: A specific cognitive disorder of ‘mind-blindness’. International Review of Psychiatry, 2(1), 81–90.
Ben-Yishay, Y., Piasetsky, E. B., & Rattok, J. (1985). A systematic method for ameliorating disorders in basic attention. In M. J. Meir, A. L. Benton, & L. Diller (Eds.), Neuropsychological rehabilitation (pp. 165–181). New York: Guilford Press.
Berger, H. J. C., Aerts, F. H. T. M., van Spaendonck, K. P. M., Cools, A. R., & Teunisse, J. P. (2003). Central coherence and cognitive shifting in relation to social improvement in high-functioning young adults with autism. Journal of Clinical and Experimental Neuropsychology, 25(4), 502–511.
Bracy, O. L. (1994). PSSCogRehab [computer software]. Indianapolis, IN: Psychological Software Services Inc.
Cicerone, K. D., Dahlberg, C., Malec, J. F., Langenbahn, D. M., Felicetti, T., Kneipp, S., et al. (2005). Evidence-based cognitive rehabilitation: Updated review of the literature from 1998 through 2002. Archives of Physical Medicine and Rehabilitation, 86(8), 1681–1692.
Couture, S. M., Penn, D. L., Losh, M., Adolphs, R., Hurley, R., & Piven, J. (2010). Comparison of social cognitive functioning in schizophrenia and high functioning autism: more convergence than divergence. Psychological Medicine, 40(4), 569–579.
Dawson, G., Rogers, S., Munson, J., Smith, M., Winter, J., Greenson, J., et al. (2010). Randomized, controlled trial of an intervention for toddlers with autism: The Early Start Denver Model. Pediatrics, 125(1), e17.
Dempster, A. P., Laird, N. M., & Rubin, D. B. (1977). Maximum likelihood from incomplete data using the EM algorithm. Journal of the Royal Statistical Society: Series B (Methodological), 39(1), 1–38.
Eack, S. M. (2012). Cognitive remediation: A new generation of psychosocial interventions for people with schizophrenia. Social Work, 57(3), 235–246.
Eack, S. M., Greenwald, D. P., Hogarty, S. S., Cooley, S. J., DiBarry, A. L., Montrose, D. M., et al. (2009). Cognitive Enhancement Therapy for early-course schizophrenia: Effects of a 2-year randomized controlled trial. Psychiatric Services, 60(11), 1468–1476.
Eack, S. M., Greenwald, D. P., Hogarty, S. S., & Keshavan, M. S. (2010a). One-year durability of the effects of Cognitive Enhancement Therapy on functional outcome in early schizophrenia. Schizophrenia Research, 120(1), 210–216.
Eack, S. M., Hogarty, G. E., Cho, R. Y., Prasad, K. M. R., Greenwald, D. P., Hogarty, S. S., et al. (2010b). Neuroprotective effects of Cognitive Enhancement Therapy against gray matter loss in early schizophrenia: Results from a 2-year randomized controlled trial. Archives of General Psychiatry, 67(7), 674–682.
Eack, S. M., Hogarty, G. E., Greenwald, D. P., Hogarty, S. S., & Keshavan, M. S. (2011). Effects of Cognitive Enhancement Therapy on employment outcomes in early schizophrenia: Results from a 2-year randomized trial. Research on Social Work Practice, 21(3), 32–42.
Fitzpatrick, L. B., Minshew, N. J., & Eack, S. M. (2013). A systematic review of psychosocial interventions for adults with autism spectrum disorders. Journal of Autism and Developmental Disorders, 43(3), 687–694.
Ganz, M. L. (2007). The lifetime distribution of the incremental societal costs of autism. Archives of Pediatrics and Adolescent Medicine, 161(4), 343–349.
García-Villamisar, D., Rojahn, J., Zaja, R. H., & Jodra, M. (2010). Facial emotion processing and social adaptation in adults with and without autism spectrum disorder. Research in Autism Spectrum Disorders, 4(4), 755–762.
Gilotty, L., Kenworthy, L., Sirian, L., Black, D. O., & Wagner, A. E. (2002). Adaptive skills and executive function in autism spectrum disorders. Child Neuropsychology, 8(4), 241–248.
Goldstein, G., Minshew, N. J., Allen, D. N., & Seaton, B. E. (2002). High-functioning autism and schizophrenia A comparison of an early and late onset neurodevelopmental disorder. Archives of Clinical Neuropsychology, 17(5), 461–475.
Green, M. F., Nuechterlein, K. H., Gold, J. M., Barch, D. M., Cohen, J., Essock, S., et al. (2004). Approaching a consensus cognitive battery for clinical trials in schizophrenia: The NIMH-MATRICS conference to select cognitive domains and test criteria. Biological Psychiatry, 56(5), 301–307.
Guilmatre, A., Dubourg, C., Mosca, A. L., Legallic, S., Goldenberg, A., Drouin-Garraud, V., et al. (2009). Recurrent rearrangements in synaptic and neurodevelopmental genes and shared biologic pathways in schizophrenia, autism, and mental retardation. Archives of General Psychiatry, 66(9), 947–956.
Gur, R. C., Schroeder, L., Turner, T., McGrath, C., Chan, R. M., Turetsky, B. I., et al. (2002). Brain activation during facial emotion processing. Neuroimage, 16(PA3), 651–662.
Heaton, R. K., Chelune, G. J., Talley, J. L., Kay, G. G., & Curtiss, G. (1993). Wisconsin card sorting test manual: Revised and expanded. Odessa, FL: Psychological Assessment Resources Inc.
Hobson, R. P., Ouston, J., & Lee, A. (1988). Emotion recognition in autism: coordinating faces and voices. Psychological Medicine, 18(4), 911–923.
Hogarty, G. E., Flesher, S., Ulrich, R., Carter, M., Greenwald, D., Pogue-Geile, M., et al. (2004). Cognitive enhancement therapy for schizophrenia. Effects of a 2-year randomized trial on cognition and behavior. Archives of General Psychiatry, 61(9), 866–876.
Hogarty, G. E., & Greenwald, D. P. (2006). Cognitive Enhancement Therapy: The training manual. University of Pittsburgh Medical Center: Authors. Available through www.CognitiveEnhancementTherapy.com.
Hogarty, G. E., Greenwald, D. P., & Eack, S. M. (2006). Durability and mechanism of effects of Cognitive Enhancement Therapy. Psychiatric Services, 57(12), 1751–1757.
Howlin, P., Goode, S., Hutton, J., & Rutter, M. (2004). Adult outcome for children with autism. Journal of Child Psychology and Psychiatry, 45(2), 212–229.
Hughes, C., Russell, J., & Robbins, T. W. (1994). Evidence for executive dysfunction in autism. Neuropsychologia, 32(4), 477–492.
Kanner, L., Rodriguez, A., & Ashenden, B. (1972). How far can autistic children go in matters of social adaptation? Journal of Autism and Developmental Disorders, 2(1), 9–33.
Kasari, C., & Lawton, K. (2010). New directions in behavioral treatment of autism spectrum disorders. Current Opinion in Neurology, 23(2), 137–143.
Kohler, C. G., Turner, T. H., Bilker, W. B., Brensinger, C. M., Siegel, S. J., Kanes, S. J., et al. (2003). Facial emotion recognition in schizophrenia: Intensity effects and error pattern. American Journal of Psychiatry, 160, 1768–1774.
Larsen, D. L., Attkisson, C. C., Hargreaves, W. A., & Nguyen, T. D. (1979). Assessment of client/patient satisfaction: Development of a general scale. Evaluation and Program Planning, 2(3), 197–207.
Lord, C., Risi, S., Lambrecht, L., Cook, E. H., Leventhal, B. L., DiLavore, P. C., et al. (2000). The autism diagnostic observation schedule—generic: A standard measure of social and communication deficits associated with the spectrum of autism. Journal of Autism and Developmental Disorders, 30(3), 205–223.
Lord, C., Rutter, M., & Couteur, A. (1994). Autism diagnostic interview-revised: A revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. Journal of Autism and Developmental Disorders, 24(5), 659–685.
Mayer, J. D., Salovey, P., Caruso, D. R., & Sitarenios, G. (2003). Measuring emotional intelligence with the MSCEIT V2.0. Emotion, 3(1), 97–105.
Mayes, S. D., & Calhoun, S. L. (2007). Learning, attention, writing, and processing speed in typical children and children with ADHD, autism, anxiety, depression, and oppositional-defiant disorder. Child Neuropsychology, 13(6), 469–493.
Minshew, N. J., Goldstein, G., & Siegel, D. J. (1997). Neuropsychologic functioning in autism: Profile of a complex information processing disorder. Journal of the International Neuropsychological Society, 3(4), 303–316.
Minshew, N. J., & Williams, D. L. (2007). The new neurobiology of autism. Archives of Neurology, 64(7), 945–950.
Mizuno, A., Liu, Y., Williams, D. L., Keller, T. A., Minshew, N. J., & Just, M. A. (2011). The neural basis of deictic shifting in linguistic perspective-taking in high-functioning autism. Brain, 134(8), 2422–2435.
Olazaran, J., Muniz, R., Reisberg, B., Pena-Casanova, J., del Ser, T., Cruz-Jentoft, A. J., et al. (2004). Benefits of cognitive-motor intervention in MCI and mild to moderate Alzheimer disease. Neurology, 63(12), 2348–2353.
Ozonoff, S. (1995). Executive functions in autism. In E. Schopler & G. B. Mesibov (Eds.), Learning and cognition in autism (pp. 3–27). New York: Plenum Press.
Penn, D. L., Corrigan, P. W., Bentall, R. P., Racenstein, J., & Newman, L. (1997). Social cognition in schizophrenia. Psychological Bulletin, 121(1), 114–132.
Pilowsky, T., Yirmiya, N., Arbelle, S., & Mozes, T. (2000). Theory of mind abilities of children with schizophrenia, children with autism, and normally developing children. Schizophrenia Research, 42(2), 145–155.
Pinkham, A. E., Hopfinger, J. B., Pelphrey, K. A., Piven, J., & Penn, D. L. (2007). Neural bases for impaired social cognition in schizophrenia and autism spectrum disorders. Schizophrenia Research, 99(1–3), 164–175.
Rapp, S., Brenes, G., & Marsh, A. P. (2002). Memory enhancement training for older adults with mild cognitive impairment: a preliminary study. Aging and Mental Health, 6(1), 5–11.
Raudenbush, D. S. W., & Bryk, D. A. S. (2002). Hierarchical linear models: Applications and data analysis methods. Thousand Oaks, CA: Sage.
Samson, A. C., Huber, O., & Gross, J. J. (2012). Emotion regulation in Asperger’s syndrome and high-functioning autism. Emotion, 12(4), 659–665.
Sasson, N., Tsuchiya, N., Hurley, R., Couture, S. M., Penn, D. L., Adolphs, R., et al. (2007). Orienting to social stimuli differentiates social cognitive impairment in autism and schizophrenia. Neuropsychologia, 45(11), 2580–2588.
Schneider, S. G., & Asarnow, R. F. (1987). A comparison of cognitive/neuropsychological impairments of nonretarded autistic and schizophrenic children. Journal of Abnormal Child Psychology, 15(1), 29–45.
Selman, R. L., & Schultz, L. H. (1990). Making a friend in youth. Chicago, IL: University of Chicago Press.
Sergi, M. J., Rassovsky, Y., Nuechterlein, K. H., & Green, M. F. (2006). Social perception as a mediator of the influence of early visual processing on functional status in schizophrenia. American Journal of Psychiatry, 163(3), 448–454.
Shattuck, P. T., Wagner, M., Narendorf, S., Sterzing, P., & Hensley, M. (2011). Post-high school service use among young adults with an autism spectrum disorder. Archives of Pediatrics and Adolescent Medicine, 165(2), 141–146.
Simon, H. A. (1979). Information processing models of cognition. Annual Review of Psychology, 30(1), 363–396.
Sugranyes, G., Kyriakopoulos, M., Corrigall, R., Taylor, E., & Frangou, S. (2011). Autism spectrum disorders and schizophrenia: Meta-analysis of the neural correlates of social cognition. PLoS ONE, 6(10), e25322.
Temple, E., Deutsch, G. K., Poldrack, R. A., Miller, S. L., Tallal, P., Merzenich, M. M., et al. (2003). Neural deficits in children with dyslexia ameliorated by behavioral remediation: Evidence from functional MRI. Proceedings of the National Academy of Sciences, 100(5), 2860–2865.
Volkmar, F. R., Lord, C., Bailey, A., Schultz, R. T., & Klin, A. (2004). Autism and pervasive developmental disorders. Journal of Child Psychology and Psychiatry, 45(1), 135–170.
Wang, A. T., Lee, S. S., Sigman, M., & Dapretto, M. (2006). Neural basis of irony comprehension in children with autism: the role of prosody and context. Brain, 129(4), 932–943.
Wechsler, D. (1999). Manual for the Wechsler abbreviated intelligence scale. San Antonio, TX: The Psychological Corporation.
Williams, D. L., Goldstein, G., Carpenter, P. A., & Minshew, N. J. (2005). Verbal and spatial working memory in autism. Journal of Autism and Developmental Disorders, 35(6), 747–756.
Wykes, T., Huddy, V., Cellard, C., McGurk, S. R., & Czobor, P. (2011). A meta-analysis of cognitive remediation for schizophrenia: Methodology and effect sizes. American Journal of Psychiatry, 168(5), 472–485.
Acknowledgments
This work was supported by NIH grants MH-85851 (NJM and SME), RR-24154 (SME), MH-95783 (SME) and HD-55748 (NJM), as well as grants from Autism Speaks (NJM and SME), the Department of Defense (NJM and SME), and the Pennsylvania Department of Health (NJM).
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Eack, S.M., Greenwald, D.P., Hogarty, S.S. et al. Cognitive Enhancement Therapy for Adults with Autism Spectrum Disorder: Results of an 18-month Feasibility Study. J Autism Dev Disord 43, 2866–2877 (2013). https://doi.org/10.1007/s10803-013-1834-7
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DOI: https://doi.org/10.1007/s10803-013-1834-7