Abstract
This study examined the measurement tools and target symptoms/skills used to assess treatment response during Autism Spectrum Disorder (ASD) intervention trials from 2001 through 2010. Data from 195 prospective trials were analyzed. There were 289 unique measurement tools, of which 61.6 % were used only once, and 20.8 % were investigator-designed. Only three tools were used in more than 2 % of the studies, and none were used in more than 7 % of studies. Studies investigated an average of 11.4 tool-symptom combinations per trial, with as many as 45 in one study. These results represent a lack of consistency in outcome measurements in ASD intervention trials. These findings highlight the need to set guidelines for appropriate outcome measurement in the ASD field.
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Aman, M. G., Burrow, W. H., & Wolford, P. L. (1995). The aberrant behavior checklist-community: Factor validity and effect of subject variables for adults in group homes. American Journal on Mental Retardation, 100(3), 283–292.
Aman, M. G., Singh, N. N., Stewart, A. W., & Field, C. J. (1985). The aberrant behavior checklist: A behavior rating scale for the assessment of treatment effects. American Journal of Mental Deficiency, 89(5), 485–491.
American Psychiatric Association. (2000). Diagnostic and statistical manual of mental disorders. (4th edition text revision; DSM IV-TR). Washington, DC: American Psychiatric Publishing.
American Psychiatric Association. (2012). American psychiatric association DSM-5 development: Disorders usually first diagnosed in infancy, childhood, or adolescence. Retrieved from: http://www.dsm5.org. Last accessed July 16, 2012.
Bayley, N. (1993). Bayley scales of infant development (2nd ed.). San Antonio, TX: Psychological Corporation.
Bertoglio, K., James, S. J., Deprey, L., Brule, N., & Hendren, R. L. (2010). Pilot study of the effect of methyl B12 treatment on behavioral and biomarker measures in children with autism. The Journal of Alternative and Complementary Medicine, 16(5), 555–560.
Campbell, M., Kafantaris, V., Malone, R. P., Kowalik, S. C., & Locascio, J. J. (1991). Diagnostic and assessment issues related to pharmacotherapy for children and asolescents with autism. Behavior Modification, 15(3), 326–354.
Centers for Disease Control, Prevention. (2012). Prevalence of autism spectrum disorders—Autism and developmental disabilities monitoring network, 14 Sites, United States, 2008. Morbidity and Mortality Weekly Report, 61(SS03), 1–19.
Cohen, I. L. (2003). Criterion-related validity of the PDD behavior inventory. Journal of Autism and Developmental Disorders, 33(1), 47–53.
Cohen, I. L., Schmidt-Lackner, S., Romanczyk, R., & Sudhalter, V. (2003). The PDD behavior inventory: A rating scale for assessing response to intervention in children with pervasive developmental disorder. Journal of Autism and Developmental Disorders, 33(1), 31–45.
Conners, C. K., Sitarenios, G., Parker, J. D. A., & Epstein, J. N. (1998). The revised Conners’ parent rating scale (CPRS-R): Factor structure, reliability, and criterion validity. Journal of Abnormal Child Psychology, 26(4), 257–268.
Garfin, D. G., McCallon, D., & Cox, R. (1988). Validity and reliability of the childhood autism rating scale with autistic adolescents. Journal of Autism and Developmental Disorders, 18(3), 367–378.
Gray, K. M., Tonge, B. J., & Sweeney, D. J. (2008). Using the autism diagnostic interview-revised and the autism diagnostic observation schedule with young children with developmental delay: Evaluating diagnostic validity. Journal of Autism and Developmental Disorders, 38(4), 657–667.
Guy, W. (1976). ECDEU assessment manual for psychopharmacology, Publication No. 76–338. Rockville, MD: U.S. DHEW, NIMH.
Kasari, C. (2002). Assessing change in early intervention programs for children with autism. Journal of Autism and Developmental Disorders, 32(5), 447–461.
Leekam, S. R., Prior, M. R., & Uljarevic, M. (2011). Restricted and repetitive behaviors in autism spectrum disorders: A review of research in the last decade. Psychological Bulletin, 137(4), 562–593.
Levy, S. E., Mandell, D. S., & Schultz, R. T. (2009). Autism. Lancet, 374(9701), 1627–1638.
Lord, C., & Corsello, C. (2005). Diagnostic instruments in autistic spectrum disorders. In F. R. Volkmar, R. Paul, A. Klin, & D. J. Cohen (Eds.), Handbook of autism and pervasive developmental disorders, vol. 2: Assessment, interventions, and policy (3rd ed., pp. 730–771). Hoboken, NJ: Wiley.
Lord, C., Rutter, M., DiLavore, P. C., & Risi, S. (2002). Autism diagnostic observation schedule (ADOS). Los Angeles: Western Psychological Services.
Lord, C., Rutter, M., DiLavore, P. C., Risi, S., Gotham, K., & Bishop, S. (2012). Autism diagnostic observation schedule, second edition: ADOS-2. Los Angeles: Western Psychological Services.
Lord, C., Wagner, A., Rogers, S., Szatmari, P., Aman, M., Charman, T., et al. (2005). Challenges in evaluating psychosocial interventions for autistic spectrum disorders. Journal of Autism and Developmental Disorders, 35(6), 695–708.
Magiati, I., Moss, J., Yates, R., Charman, T., & Howlin, P. (2011). Is the autism treatment evaluation checklist a useful tool for monitoring progress in children with autism spectrum disorders? Journal of Intellectual Disability Research, 55(3), 302–312.
Matson, J. L. (2007). Determining treatment outcome in early intervention programs for autism spectrum disorders: A critical analysis of measurement issues in learning based interventions. Research in Developmental Disabilities, 28(2), 207–218.
National Institutes of Health. (2011). Publication characteristics (Publication Types)—Scope Notes. U.S. National Library of Medicine. Retrieved from http://www.nlm.nih.gov.proxy.library.nd.edu/mesh/pubtypes.html. Last accessed March 26, 2012.
ProQuest LLC. (2012). Glossary. Retrieved from: http://search.proquest.com.proxy.library.nd.edu/help/academic/webframe.html?Search_Tips.html. Last accessed March 26, 2012.
Rogers, S. J., & Vismara, L. A. (2008). Empirically supported comprehensive treatments for early autism. Journal of Clinical Child and Adolescent Psychology, 37, 8–38.
Roseman, B., Schneider, E., Crimmins, D., Bostwick, H., Visintainer, P., Jaskow, P. A., et al. (2001). What to measure in autism drug trials [Letter to the editor]. Journal of Autism and Developmental Disorders, 31(3), 361–362.
Rutter, M., Le Couteur, A., & Lord, C. (2003). Autism diagnostic interview-revised. Los Angeles: Western Psychological Services.
Schopler, E., Reichler, R., & Renner, B. (1988). The childhood autism rating scale (CARS). Los Angeles, CA: Western Psychological.
Sevin, J. A., Matson, J. L., Coe, D. A., Fee, V. E., & Sevin, B. M. (1991). A comparison and evaluation of three commonly used autism scales. Journal of Autism and Developmental Disorders, 21(4), 417–432.
Sparrow, S., Balla, D., & Cicchetti, D. V. (1984). The Vineland adaptive behavior scales (Survey Form). Circle Pines, MN: American Guidance Service.
Teal, M. B., & Wiebe, M. J. (1986). A validity analysis of selected instruments used to assess autism. Journal of Autism and Developmental Disorders, 16(4), 485–494.
Virués-Ortega, J. (2010). Applied behavior analytic intervention for autism in early childhood: Meta-analysis, meta-regression and dose–response meta-analysis of multiple outcomes. Clinical Psychology Review, 30(4), 387–399.
Volkmar, F., Lord, C., Bailey, A., Schultz, R. T., & Klin, A. (2004). Autism and pervasive developmental disorders. Journal of Child Psychology and Psychiatry, 45, 135–170.
Wink, L. K., Erickson, C. A., & McDougle, C. J. (2010). Pharmacologic treatment of behavioral symptoms associated with autism and other pervasive developmental disorders. Journal of Autism and Developmental Disorders, 12(6), 529–538.
World Health Organization. (2008). International statistical classification of diseases and related health problems, 10th revision (ICD-10). New York, NY: Author.
Acknowledgments
The study was supported in part by the Glynn Family Honors Program at the University of Notre Dame and a grant from the Boler Family Foundation (J. Diehl, P.I.). We would like to thank Ellen Bolte, R.N., for her thoughtful comments as we developed this review, and Stephany Mazur for her feedback during the editing process.
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The authors declare that they have no conflict of interest.
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Bolte, E.E., Diehl, J.J. Measurement Tools and Target Symptoms/Skills Used to Assess Treatment Response for Individuals with Autism Spectrum Disorder. J Autism Dev Disord 43, 2491–2501 (2013). https://doi.org/10.1007/s10803-013-1798-7
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DOI: https://doi.org/10.1007/s10803-013-1798-7