Skip to main content
Log in

Sex Differences in the Timing of Identification Among Children and Adults with Autism Spectrum Disorders

  • Published:
Journal of Autism and Developmental Disorders Aims and scope Submit manuscript

Abstract

To examine differences by sex in the timing of identification of individuals with autism spectrum disorders (ASD), survey data were collected in the Netherlands from 2,275 males and females with autistic disorder, Asperger’s syndrome and PDD-NOS. Among participants <18 years of age, females with Asperger’s syndrome were identified later than males. Among participants ≥18 years of age, females with autistic disorder were identified later than males. In more recent years, girls with Asperger’s syndrome are diagnosed later than boys, confirming earlier findings. In adults, the delayed timing of diagnosis in females with autistic disorder may be related to changing practices in diagnosis over time. Strategies for changing clinician behaviour to improve recognition of ASD in females are needed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Baird, G., Douglas, H. R., & Murphy, M. S. (2011). GUIDELINES recognising and diagnosing autism in children and young people: Summary of NICE guidance. British Medical Journal, 343, d6360.

    Article  PubMed  Google Scholar 

  • Banach, R., Thompson, A., Szatmari, P., Goldberg, J., Tuff, L., Zwaigenbaum, L., et al. (2009). Brief report: Relationship between non-verbal IQ and gender in autism. Journal of Autism and Developmental Disorders, 39, 188–193.

    Article  PubMed  Google Scholar 

  • Barbaro, J., & Dissanayake, C. (2009). Autism spectrum disorders in infancy and toddlerhood: A review of the evidence on early signs, early identification tools, and early diagnosis. Journal of Developmental and Behavioral Pediatrics, 30, 447–459.

    Article  PubMed  Google Scholar 

  • Begeer, S., El Bouk, S., Boussaid, W., Terwogt, M. M., & Koot, H. M. (2009). Underdiagnosis and referral bias of autism in ethnic minorities. Journal of Autism and Developmental Disorders, 39, 142–148.

    Article  PubMed  Google Scholar 

  • Carter, A. S., Black, D. O., Tewani, S., Connolly, C. E., Kadlec, M. B., & Tager-Flusberg, H. (2007). Sex differences in toddlers with autism spectrum disorders. Journal of Autism and Developmental Disorders, 37, 86–97.

    Article  PubMed  Google Scholar 

  • Centers for Disease Control and Prevention. (2012). Prevalence of autism spectrum disorders–autism and developmental disabilities monitoring network, United States, 2008. MMWR, 61, 1–19.

    Google Scholar 

  • Centraal Bureau voor de Statistiek. (2008). Provincie op maat. Den Haag: CBS.

    Google Scholar 

  • Crick, N. R., & Zahn-Waxler, C. (2003). The development of psychopathology in females and males: Current progress and future challenges. Development and Psychopathology, 15, 719–742.

    Article  PubMed  Google Scholar 

  • Dawson, G. (2008). Early behaviorial intervention, brain plasticity, and the prevention of autism spectrum disorder. Development and Psychopathology, 20, 775–803.

    Article  PubMed  Google Scholar 

  • Emerson, E. (2012). Deprivation, ethnicity and the prevalence of intellectual and developmental disabilities. Journal of Epidemiology and Community Health, 66, 218–224.

    Article  PubMed  Google Scholar 

  • Filipek, P. A., Accardo, P. J., Baranek, G. T., Cook, E. H., Dawson, G., Gordon, B., et al. (1999). The screening and diagnosis of autistic spectrum disorders. Journal of Autism and Developmental Disorders, 29, 439–484.

    Article  PubMed  Google Scholar 

  • Fombonne, E. (2003). Epidemiological surveys of autism and other pervasive developmental disorders: An update. Journal of Autism and Developmental Disorders, 33, 365–382.

    Article  PubMed  Google Scholar 

  • Fountain, C., King, M. D., & Bearman, P. S. (2011). Age of diagnosis for autism: Individual and community factors across 10 birth cohorts. Journal of Epidemiology and Community Health, 65, 503–510.

    Article  PubMed  Google Scholar 

  • Fujiwara, T., Okuyama, M., & Funahashi, K. (2011). Factors influencing time lag between first parental concern and first visit to child psychiatric services in children with autism spectrum disorders in Japan. Research in Autism Spectrum Disorders, 5, 584–591.

    Article  Google Scholar 

  • Giarelli, E., Wiggins, L. D., Rice, C. E., Levy, S. E., Kirby, R. S., Pinto-Martin, J., et al. (2010). Sex differences in the evaluation and diagnosis of autism spectrum disorders among children. Disability and Health Journal, 3, 107–116.

    Article  PubMed  Google Scholar 

  • Hartley, S. L., & Sikora, D. M. (2009). Sex differences in autism spectrum disorder: An examination of developmental functioning, autistic symptoms, and coexisting behaviour problems in toddlers. Journal of Autism and Developmental Disorders, 39, 1715–1722.

    Article  PubMed  Google Scholar 

  • Hertz-Picciotto, I., & Delwiche, L. (2009). The rise in autism and the role of age at diagnosis. Epidemiology, 20, 84–90.

    Article  PubMed  Google Scholar 

  • Holtmann, M., Bolte, S., & Poustka, F. (2007). Autism spectrum disorders: Sex differences in autistic behaviour domains and coexisting psychopathology. Developmental Medicine and Child Neurology, 49, 361–366.

    Article  PubMed  Google Scholar 

  • Horovitz, M., Matson, J. L., & Sipes, M. (2011). Gender differences in symptoms of comorbidity in toddlers with ASD using the BISCUIT-Part 2. Developmental Neurorehabilitation, 14, 94–100.

    Article  PubMed  Google Scholar 

  • Horovitz, M., Matson, J. L., Turygin, N., & Beighley, J. S. (2012). The relationship between gender and age of first concern in toddlers with autism spectrum disorders. Research in Autism Spectrum Disorders, 6(1), 466–471.

    Article  Google Scholar 

  • Klin, A., Jones, W., Schultz, R., & Volkmar, F. (2003). The enactive mind, or from actions to cognition: Lessons from autism. Philosophical Transactions of the Royal Society of London. Series B, Biological sciences, 358, 345–360.

    Article  PubMed  Google Scholar 

  • Kopp, S., & Gillberg, C. (2011). The autism spectrum screening questionnaire (ASSQ)-revised extended version (ASSQ-REV): An instrument for better capturing the autism phenotype in girls? A preliminary study involving 191 clinical cases and community controls. Research in Developmental Disabilities, 32, 2875–2888.

    Article  PubMed  Google Scholar 

  • Lord, C. (1995). Follow-up of two-year-olds referred for possible autism. Journal of Child Psychology and Psychiatry, 36, 1365–1382.

    Article  PubMed  Google Scholar 

  • Lord, C., Schopler, E., & Revicki, D. (1982). Sex-differences in autism. Journal of Autism and Developmental Disorders, 12, 317–330.

    Article  PubMed  Google Scholar 

  • Mandell, D. S., Novak, M. M., & Zubritsky, C. D. (2005). Factors associated with age of diagnosis among children with autism spectrum disorders. Pediatrics, 116, 1480–1486.

    Article  PubMed  Google Scholar 

  • Mayes, S. D., & Calhoun, S. L. (2011). Impact of IQ, age, SES, gender, and race on autistic symptoms. Research in Autism Spectrum Disorders, 5, 749–757.

    Article  Google Scholar 

  • McLennan, J. D., Lord, C., & Schopler, E. (1993). Sex-differences in higher functioning people with autism. Journal of Autism and Developmental Disorders, 23(2), 217–227.

    Article  PubMed  Google Scholar 

  • Nederlandse Vereniging voor Autisme (NVA). (2008). Een plek om te leven. Een onderzoek naar de leefsituatie van mensen met autisme (A place to live. A study on the daily circumstances of individual with autism). Bilthoven: NVA.

  • Ouellette-Kuntz, H. M. J., Coo, H., Lam, M., Yu, C. T., Breitenbach, M. M., Hennessey, P. E., et al. (2009). Age at diagnosis of autism spectrum disorders in four regions of Canada. Canadian Journal of Public Health-Revue Canadienne de Sante Publique, 100, 268–273.

    PubMed  Google Scholar 

  • Reichow, B. (2012). Overview of meta-analyses on early intensive behavioral intervention for young children with autism spectrum disorders. Journal of Autism and Developmental Disorders, 42, 512–520.

    Article  PubMed  Google Scholar 

  • Rivet, T. T., & Matson, J. L. (2011a). Gender differences in core symptomatology in autism spectrum disorders across the lifespan. Journal of Developmental and Physical Disabilities, 23, 399–420.

    Article  Google Scholar 

  • Rivet, T. T., & Matson, J. L. (2011b). Review of gender differences in core symptomatology in autism spectrum disorders. Research in Autism Spectrum Disorders, 5(3), 957–976.

    Article  Google Scholar 

  • Shattuck, P. T., Durkin, M., Maenner, M., Newschaffer, C., Mandell, D. S., Wiggins, L., et al. (2009). Timing of identification among children with an autism spectrum disorder: Findings from a population-based surveillance study. Journal of the American Academy of Child and Adolescent Psychiatry, 48, 474–483.

    Article  PubMed  Google Scholar 

  • Volkmar, F. R., Bregman, J., Cohen, D. J., & Cicchetti, D. V. (1988). Dsm-Iii and Dsm-Iii-R diagnoses of autism. American Journal of Psychiatry, 145, 1404–1408.

    PubMed  Google Scholar 

  • Wiggins, L. D., Baio, J., & Rice, C. (2006). Examination of the time between first evaluation and first autism spectrum diagnosis in a population-based sample. Journal of Developmental and Behavioral Pediatrics, 27, S79–S87.

    Article  PubMed  Google Scholar 

  • Wing, L. (1981). Sex-ratios in early-childhood autism and related conditions. Psychiatry Research, 5, 129–137.

    Article  PubMed  Google Scholar 

Download references

Acknowledgments

This work was supported by Stichting Nuts Ohra [SNO-T-0702-78] and Fonds PGO [S03881/2007U01363/TB07], The Netherlands.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Sander Begeer.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Begeer, S., Mandell, D., Wijnker-Holmes, B. et al. Sex Differences in the Timing of Identification Among Children and Adults with Autism Spectrum Disorders. J Autism Dev Disord 43, 1151–1156 (2013). https://doi.org/10.1007/s10803-012-1656-z

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10803-012-1656-z

Keywords

Navigation