Date: 05 May 2012
Is Maternal Influenza or Fever During Pregnancy Associated with Autism or Developmental Delays? Results from the CHARGE (CHildhood Autism Risks from Genetics and Environment) Study
We analyzed data from case groups of 538 children with autism spectrum disorders (ASD) and 163 with developmental delays (DD), and from 421 typically developing controls to assess associations with maternal influenza or fever during pregnancy. Exposure information was obtained by telephone interviews, and outcomes were clinically confirmed. Though neither ASD nor DD was associated with influenza, both were associated with maternal fever during pregnancy: OR’s (odds ratios) were 2.12 (95 % CI 1.17, 3.84) and 2.50 (95 % CI 1.20, 5.20) respectively. However, the fever-associated ASD risk was attenuated among mothers who reported taking antipyretic medications (OR = 1.30, 95 % CI 0.59, 2.84), but remained elevated for those who did not (OR = 2.55, 95 % CI 1.30, 4.99).
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- Is Maternal Influenza or Fever During Pregnancy Associated with Autism or Developmental Delays? Results from the CHARGE (CHildhood Autism Risks from Genetics and Environment) Study
Journal of Autism and Developmental Disorders
Volume 43, Issue 1 , pp 25-33
- Cover Date
- Print ISSN
- Online ISSN
- Springer US
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- Maternal influenza
- Anti-fever medication
- Industry Sectors
- Author Affiliations
- 1. Department of Public Health Sciences, MS1C, University of California, Davis, CA, 95616, USA
- 4. Division of Research, Kaiser Permanente, Oakland, CA, USA
- 2. The UC Davis Medical Investigation of Neurodevelopmental Disorders (MIND) Institute, Sacramento, CA, USA
- 3. Department of Pediatrics, University of California, Davis, CA, USA