Original Paper

Journal of Autism and Developmental Disorders

, Volume 42, Issue 11, pp 2431-2439

First online:

The Effect of Gestational Age on Symptom Severity in Children with Autism Spectrum Disorder

  • Tammy Z. MovsasAffiliated withDepartment of Epidemiology, College of Human Medicine, Michigan State University Email author 
  • , Nigel PanethAffiliated withDepartment of Epidemiology and Pediatrics & Human Development, College of Human Medicine, Michigan State University

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Between 2006 and 2010, two research-validated instruments, Social Communication Questionnaire (SCQ) and Social Responsiveness Scale (SRS) were filled out online by 4,188 mothers of Autism Spectrum Disorder (ASD) children, aged 4–21, as part of voluntary parental participation in a large web-based registry. Univariate and multivariate linear regression analysis (adjusted for child’s sex, ability to verbalize, categorical IQ score, and fetal growth rate) demonstrated significantly higher SCQ and SRS scores for ASD children of both preterm (<37 weeks) and post-term (>42 weeks) gestational age (GA) compared to ASD children of normal GA, thus indicating that both preterm and post-term children manifest increased ASD symptomatology. Normal GA at birth appears to mitigate the severity of autistic social impairment in ASD children.


Autism Spectrum Disorder symptoms Preterm Post-term Post-mature SCQ SRS