Journal of Autism and Developmental Disorders

, Volume 42, Issue 9, pp 1928–1938

Maternal and Paternal Age are Jointly Associated with Childhood Autism in Jamaica

Authors

    • Division of Epidemiology, Human Genetics, and Environmental Sciences (EHGES), School of Public HealthThe University of Texas Health Science Center at Houston (UTHealth)
    • Biostatistics/Epidemiology/Research Design (BERD) Core, Center for Clinical and Translational Sciences (CCTS)The University of Texas Health Science Center at Houston (UTHealth)
  • Maureen Samms-Vaughan
    • Department of Child HealthThe University of the West Indies (UWI)
  • Katherine A. Loveland
    • Department of Psychiatry and Behavioral Sciences, UTHealth Medical SchoolUTHealth
    • Department of Psychiatry and Behavioral Sciences, Changing Lives through Autism Spectrum Services (C.L.A.S.S.) ClinicUTHealth
    • Center of Excellence on Development and PsychopathologyUTHealth
  • Deborah A. Pearson
    • Division of Child and Adolescent Psychiatry, Department of Psychiatry and Behavioral Sciences, UTHealth Medical SchoolUTHealth
  • Jan Bressler
    • Human Genetics Center, School of Public HealthUTHealth
  • Zhongxue Chen
    • Biostatistics/Epidemiology/Research Design Core, Center for Clinical and Translational SciencesUTHealth
  • Manouchehr Ardjomand-Hessabi
    • Biostatistics/Epidemiology/Research Design Core, Center for Clinical and Translational SciencesUTHealth
  • Sydonnie Shakespeare-Pellington
    • Department of Child HealthThe University of the West Indies (UWI)
  • Megan L. Grove
    • Human Genetics Center, School of Public HealthUTHealth
  • Compton Beecher
    • Department of Basic Medical Sciences, Caribbean GeneticsThe University of the West Indies
  • Kari Bloom
    • Biostatistics/Epidemiology/Research Design Core, Center for Clinical and Translational SciencesUTHealth
  • Eric Boerwinkle
    • Human Genetics Center, School of Public HealthUTHealth
    • Division of Epidemiology, Human Genetics, and Environmental Sciences, School of Public HealthUTHealth
Original Paper

DOI: 10.1007/s10803-011-1438-z

Cite this article as:
Rahbar, M.H., Samms-Vaughan, M., Loveland, K.A. et al. J Autism Dev Disord (2012) 42: 1928. doi:10.1007/s10803-011-1438-z

Abstract

Several studies have reported maternal and paternal age as risk factors for having a child with Autism Spectrum Disorder (ASD), yet the results remain inconsistent. We used data for 68 age- and sex-matched case–control pairs collected from Jamaica. Using Multivariate General Linear Models (MGLM) and controlling for parity, gestational age, and parental education, we found a significant (p < 0.0001) joint effect of parental ages on having children with ASD indicating an adjusted mean paternal age difference between cases and controls of [5.9 years; 95% CI (2.6, 9.1)] and a difference for maternal age of [6.5 years; 95% CI (4.0, 8.9)]. To avoid multicollinearity in logistic regression, we recommend joint modeling of parental ages as a vector of outcome variables using MGLM.

Keywords

Autism spectrum disordersMaternal agePaternal ageMultivariate General Linear ModelsMulticollinearity

Copyright information

© Springer Science+Business Media, LLC 2012