Date: 10 Dec 2011
Melatonin for Sleep in Children with Autism: A Controlled Trial Examining Dose, Tolerability, and Outcomes
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Supplemental melatonin has shown promise in treating sleep onset insomnia in children with autism spectrum disorders (ASD). Twenty-four children, free of psychotropic medications, completed an open-label dose-escalation study to assess dose–response, tolerability, safety, feasibility of collecting actigraphy data, and ability of outcome measures to detect change during a 14-week intervention. Supplemental melatonin improved sleep latency, as measured by actigraphy, in most children at 1 or 3 mg dosages. It was effective in week 1 of treatment, maintained effects over several months, was well tolerated and safe, and showed improvement in sleep, behavior, and parenting stress. Our findings contribute to the growing literature on supplemental melatonin for insomnia in ASD and inform planning for a large randomized trial in this population.
Dr. Burnette has moved to University of New Mexico subsequent to the time of study.
An erratum to this article can be found at http://dx.doi.org/10.1007/s10803-012-1507-y.
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- Melatonin for Sleep in Children with Autism: A Controlled Trial Examining Dose, Tolerability, and Outcomes
Journal of Autism and Developmental Disorders
Volume 42, Issue 8 , pp 1729-1737
- Cover Date
- Print ISSN
- Online ISSN
- Springer US
- Additional Links
- Clinical trial
- Children’s sleep habits questionnaire
- Child behavior checklist
- Autism diagnostic observation schedule
- Industry Sectors
- Author Affiliations
- 1. Sleep Disorders Division, Department of Neurology and Kennedy Center, Vanderbilt University School of Medicine, 1161 21st Avenue South, Room Room A-0116, Nashville, TN, 37232, USA
- 2. Sleep Disorders Division, Department of Neurology, Vanderbilt University School of Medicine, Nashville, TN, 37232, USA
- 3. Department of Pediatrics, Monroe Carell Children’s Hospital at Vanderbilt, Nashville, TN, 37232, USA
- 4. Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN, 37232, USA