Original Paper

Journal of Autism and Developmental Disorders

, Volume 42, Issue 7, pp 1435-1445

Behavioral Correlates of Maternal Antibody Status Among Children with Autism

  • Daniel BraunschweigAffiliated withDivision of Rheumatology/Allergy and Clinical Immunology, University of California, DavisThe M.I.N.D. Institute, University of California, DavisNIEHS Center for Children’s Environmental Health, University of California, Davis
  • , Paul DuncansonAffiliated withDivision of Rheumatology/Allergy and Clinical Immunology, University of California, Davis
  • , Robert BoyceAffiliated withDivision of Rheumatology/Allergy and Clinical Immunology, University of California, Davis
  • , Robin HansenAffiliated withDepartment of Pediatrics, University of California, DavisThe M.I.N.D. Institute, University of California, DavisNIEHS Center for Children’s Environmental Health, University of California, Davis
  • , Paul AshwoodAffiliated withDepartment of Medical Microbiology and Immunology, University of California, DavisThe M.I.N.D. Institute, University of California, DavisNIEHS Center for Children’s Environmental Health, University of California, Davis
  • , Isaac N. PessahAffiliated withDepartment of Veterinary Molecular Biosciences, University of California, DavisThe M.I.N.D. Institute, University of California, DavisNIEHS Center for Children’s Environmental Health, University of California, Davis
  • , Irva Hertz-PicciottoAffiliated withDepartment of Public Health Sciences, Division of Epidemiology, University of California, DavisThe M.I.N.D. Institute, University of California, DavisNIEHS Center for Children’s Environmental Health, University of California, Davis
  • , Judy Van de WaterAffiliated withDivision of Rheumatology/Allergy and Clinical Immunology, University of California, DavisThe M.I.N.D. Institute, University of California, DavisNIEHS Center for Children’s Environmental Health, University of California, Davis Email author 

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Abstract

Autism spectrum disorders (ASDs) affect approximately 1 in 110 children in the United States. This report profiles fetal-brain reactive autoantibodies of a large cohort of mothers of children with autism and controls, yielding significant associations between the presence of IgG reactivity to fetal brain proteins at 37 and 73 kDa and a childhood diagnosis of full autism (p = 0.0005), which also correlated with lower expressive language scores (p = 0.005). Additionally, we report on reactivity to proteins at 39 and 73 kDa, which correlated with the broader diagnosis of ASD (p = 0.0007) and increased irritability on the Aberrant Behavioral Checklist (p = 0.05). This study provides evidence of multiple patterns of reactivity to fetal brain proteins by maternal antibodies associated with ASD and specific childhood behavioral outcomes.

Keywords

Autism Maternal antibodies Autoantibodies Fetal brain