Journal of Autism and Developmental Disorders

, Volume 42, Issue 7, pp 1435–1445

Behavioral Correlates of Maternal Antibody Status Among Children with Autism

Authors

  • Daniel Braunschweig
    • Division of Rheumatology/Allergy and Clinical ImmunologyUniversity of California, Davis
    • The M.I.N.D. InstituteUniversity of California, Davis
    • NIEHS Center for Children’s Environmental HealthUniversity of California, Davis
  • Paul Duncanson
    • Division of Rheumatology/Allergy and Clinical ImmunologyUniversity of California, Davis
  • Robert Boyce
    • Division of Rheumatology/Allergy and Clinical ImmunologyUniversity of California, Davis
  • Robin Hansen
    • Department of PediatricsUniversity of California, Davis
    • The M.I.N.D. InstituteUniversity of California, Davis
    • NIEHS Center for Children’s Environmental HealthUniversity of California, Davis
  • Paul Ashwood
    • Department of Medical Microbiology and ImmunologyUniversity of California, Davis
    • The M.I.N.D. InstituteUniversity of California, Davis
    • NIEHS Center for Children’s Environmental HealthUniversity of California, Davis
  • Isaac N. Pessah
    • Department of Veterinary Molecular BiosciencesUniversity of California, Davis
    • The M.I.N.D. InstituteUniversity of California, Davis
    • NIEHS Center for Children’s Environmental HealthUniversity of California, Davis
  • Irva Hertz-Picciotto
    • Department of Public Health Sciences, Division of EpidemiologyUniversity of California, Davis
    • The M.I.N.D. InstituteUniversity of California, Davis
    • NIEHS Center for Children’s Environmental HealthUniversity of California, Davis
    • Division of Rheumatology/Allergy and Clinical ImmunologyUniversity of California, Davis
    • The M.I.N.D. InstituteUniversity of California, Davis
    • NIEHS Center for Children’s Environmental HealthUniversity of California, Davis
Original Paper

DOI: 10.1007/s10803-011-1378-7

Cite this article as:
Braunschweig, D., Duncanson, P., Boyce, R. et al. J Autism Dev Disord (2012) 42: 1435. doi:10.1007/s10803-011-1378-7

Abstract

Autism spectrum disorders (ASDs) affect approximately 1 in 110 children in the United States. This report profiles fetal-brain reactive autoantibodies of a large cohort of mothers of children with autism and controls, yielding significant associations between the presence of IgG reactivity to fetal brain proteins at 37 and 73 kDa and a childhood diagnosis of full autism (p = 0.0005), which also correlated with lower expressive language scores (p = 0.005). Additionally, we report on reactivity to proteins at 39 and 73 kDa, which correlated with the broader diagnosis of ASD (p = 0.0007) and increased irritability on the Aberrant Behavioral Checklist (p = 0.05). This study provides evidence of multiple patterns of reactivity to fetal brain proteins by maternal antibodies associated with ASD and specific childhood behavioral outcomes.

Keywords

AutismMaternal antibodiesAutoantibodiesFetal brain

Copyright information

© Springer Science+Business Media, LLC 2011