Journal of Autism and Developmental Disorders

, Volume 42, Issue 7, pp 1435–1445

Behavioral Correlates of Maternal Antibody Status Among Children with Autism

  • Daniel Braunschweig
  • Paul Duncanson
  • Robert Boyce
  • Robin Hansen
  • Paul Ashwood
  • Isaac N. Pessah
  • Irva Hertz-Picciotto
  • Judy Van de Water
Original Paper

DOI: 10.1007/s10803-011-1378-7

Cite this article as:
Braunschweig, D., Duncanson, P., Boyce, R. et al. J Autism Dev Disord (2012) 42: 1435. doi:10.1007/s10803-011-1378-7

Abstract

Autism spectrum disorders (ASDs) affect approximately 1 in 110 children in the United States. This report profiles fetal-brain reactive autoantibodies of a large cohort of mothers of children with autism and controls, yielding significant associations between the presence of IgG reactivity to fetal brain proteins at 37 and 73 kDa and a childhood diagnosis of full autism (p = 0.0005), which also correlated with lower expressive language scores (p = 0.005). Additionally, we report on reactivity to proteins at 39 and 73 kDa, which correlated with the broader diagnosis of ASD (p = 0.0007) and increased irritability on the Aberrant Behavioral Checklist (p = 0.05). This study provides evidence of multiple patterns of reactivity to fetal brain proteins by maternal antibodies associated with ASD and specific childhood behavioral outcomes.

Keywords

AutismMaternal antibodiesAutoantibodiesFetal brain

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Daniel Braunschweig
    • 1
    • 6
    • 7
  • Paul Duncanson
    • 1
  • Robert Boyce
    • 1
  • Robin Hansen
    • 2
    • 6
    • 7
  • Paul Ashwood
    • 3
    • 6
    • 7
  • Isaac N. Pessah
    • 4
    • 6
    • 7
  • Irva Hertz-Picciotto
    • 5
    • 6
    • 7
  • Judy Van de Water
    • 1
    • 6
    • 7
  1. 1.Division of Rheumatology/Allergy and Clinical ImmunologyUniversity of California, DavisDavisUSA
  2. 2.Department of PediatricsUniversity of California, DavisDavisUSA
  3. 3.Department of Medical Microbiology and ImmunologyUniversity of California, DavisDavisUSA
  4. 4.Department of Veterinary Molecular BiosciencesUniversity of California, DavisDavisUSA
  5. 5.Department of Public Health Sciences, Division of EpidemiologyUniversity of California, DavisDavisUSA
  6. 6.The M.I.N.D. InstituteUniversity of California, DavisDavisUSA
  7. 7.NIEHS Center for Children’s Environmental HealthUniversity of California, DavisDavisUSA