Date: 12 Feb 2011
Progress in Understanding Autism: 2007–2010
- Michael L. Rutter
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Scientific progress is discussed in relation to clinical issues; genetic issues; environmental issues; and the state of play on psychological treatments. It is concluded that substantial gains in knowledge have been achieved during the last 3 years, and there have been some unexpected findings, but major puzzles remain. We should be hopeful of ever greater gains in the years ahead, but both prevention and cure remain elusive.
Paper based on a state-of-the-art lecture in the 9th International Congress of Autism Europe in Catania, Sicily 8th–10th October 2010.
Abrahams, B. S., & Geschwind, D. H. (2008). Advances in autism genetics: On the threshold of a new neurobiology. Nature Review: Genetics, 9, 341–355.CrossRef
Afzal, M. A., Ozoemena, L. C., O’Hare, A., Kidger, K. A., Bentley, M. L., & Minor, P. D. (2006). Absence of detectable measles virus genome sequence in blood of autistic children who have had their MMR vaccination during the routine childhood immunization schedule of UK. Journal of Medical Virology, 78, 623–630.PubMedCrossRef
Asperger, H. (1944). Die ‘Autistischen Psychopathen’ im Kindesalter [Trans. ‘Autistic psychopathy’ in childhood]. Archiv fur Psychiatrie und Nervenkrankheiten, 117, 76–136.CrossRef
Atladóttir, H. O., Parner, E. T., Schendel, D., Dalsgaard, S., Thomsen, P. H., & Thorsen, P. (2007). Time trends in reported diagnoses of childhood neuropsychiatric disorders: A Danish cohort study. Archives of Pediatric and Adolescent Medicine, 161, 193–198.CrossRef
Bacchelli, A., & Maestrini, E. (2006). Autism spectrum disorders: Molecular genetic advances. American Journal of Medical Genetics C. Seminars in Medical Genetics, 142, 13–23.CrossRef
Bailey, A., & Parr, J. (2003). Implications of the broader phenotype for concepts of autism. In G. Bock & J. Goode (Eds.), Autism: Neural basis and treatment possibilities (pp 26–36). Chichester, UK: Wiley.
Baird, G., Charman, T., Pickles, A., Chandler, S., Loucas, T., Meldrum, D., et al. (2008a). Regression, developmental trajectory and associated problems in disorders in the autism spectrum. The SNAP Study, Journal of Autism& Developmental Disorders, 38, 1827–1836.CrossRef
Bolton, P. F., Carcani-Rathwell, I., Hutton, J., Goode, S., Howlin, P., & Rutter, M. L. (in press). Features and correlates of epilepsy in autism. British Journal of Psychiatry.
Buitelaar, J. K. (2003). Why have drug treatments been so disappointing? In G. Bock & J. Goode (Eds.), Autism: Neural basis and treatment possibilities (pp. 235–249). Chichester, UK: Wiley.CrossRef
Croen, L. A., Najjar, D. V., Fireman, B., & Grether, J. K. (2007). Maternal and paternal age and risk of autism spectrum disorders. Archives of Pediatric and Adolescent Medicine, 161, 334–340.CrossRef
Dawson, G., Rogers, S., Munson, J., Smith, M., Winter, J., Greenson, J., et al. (2009). Randomized, controlled trial of an intervention for toddlers with autism: The early start Denver model. Pediatrics, 125, 17–23.CrossRef
Dietz, C., Swinkels, S., van Daalen, E., van Engeland, H., & Buitelaar, J. K. (2006). Screening for autistic spectrum disorder in children aged 14–15 months. II. Population screening with the early screening of autistic traits questionnaire (ESAT): Design and general findings. Journal of Autism and Developmental Disorders, 36, 713–722.PubMedCrossRef
Dodge, K. A., & Rutter, M. (Eds.). (in press). Gene–environment interactions in developmental psychopathology: So what? New York: Guilford Press.
Elsabbagh, M., & Johnson, M. H. (2010). Getting answers from babies about autism. Trends Cognitive Science, 4, 81–87.CrossRef
Feinstein, A. (2010). A history of autism: Conversations with the pioneers. Chichester, UK: Wiley Blackwell.CrossRef
Fombonne, E. (2005). Epidemiological studies of pervasive developmental disorders. In F. Volkmar, R. Paul, A. Klin, & D. Cohen (Eds.), Handbook of autism and pervasive developmental disorders (pp 62–63). Hoboken, NJ: Wiley.
Frith, U. (1989). Autism: Explaining the enigma. Oxford, UK: Blackwell Publishing.
Frith, U. (2003). Autism: Explaining the enigma (2nd ed.). Oxford: Blackwell.
Frith, C., & Frith, U. (2008). What can we learn from structural and functional brain imaging? In M. Rutter, D. Bishop, D. Pine, S. Scott, J. Stevenson, E. Taylor, & A. Thapar (Eds.), Rutter’s child and adolescent psychiatry (5th ed., pp. 134–144). Massachusetts, USA: Blackwell Publishing.CrossRef
Green, J., Charman, T., McConachie, H., Aldred, C., Slonims, V., Howlin, P., et al. (2010). Parent-mediated communication-focused treatment in children with autism (PACT): A randomized controlled trial. The Lancet, 375, 2152–2160.CrossRef
Happé, F. (2005). The weak central coherence account of autism. In F. Volkmar, R. Paul, A. Klin, & D. Cohen (Eds.), Handbook of autism and pervasive developmental disorders (pp. 640–649). Hoboken, NJ: Wiley.
Happé, F., & Ronald, A. (2008). The ‘fractionable autism triad’: A review of evidence from behavioural, genetic, cognitive and neural research. Neuropsychological Review, 18(4), 287–304.CrossRef
Hermelin, B. (2001). Bright splinters of the mind. London, UK: Jessica Kingsley Publishers.
Howlin, P. (2003). Can early interventions alter the course of autism? In G. Bock & J. Goode (Eds.), Autism: Neural basis and treatment possibilities (pp. 250–265). Chichester, UK: Wiley.CrossRef
Howlin, P. (2005). The effectiveness of interventions for children with autism. Journal of Neural Transmission (Suppementum), 69, 101–119.
Howlin, P., Goode, S., Hutton, J., & Rutter, M. (2010). Savant skills in autism: Psychometric approaches and parental reports. In F. Happé & U. Frith (Eds.), Autism and talent (pp. 13–24). Oxford: University Press.
International Schizophrenia Consortium. (2008). Rare chromosomal deletions and duplications increase risk of schizophrenia. Nature, 455, 237–241.CrossRef
Jamain, S., Radyushkin, K., Hammerschmidt, K., Granon, S., Boretius, S., Varoqueaux, F., et al. (2008). Reduced social interaction and ultrasonic communication in a mouse model of monogenic heritable autism. Proceedings of the National Academy of Sciences of the USA, 5, 1710–1715.CrossRef
Kanner, L. (1971). Follow-up study of eleven autistic children originally reported in 1943. Journal of Autism and Childhood Schizophenia, 1, 119–145.CrossRef
Klin, A., Jones, W., Schultz, R. T., & Volkmar, F. (2005). The enactive mind—from actions to cognition: Lessons from autism. In F. Volkmar, R. Paul, A. Klin, & D. Cohen (Eds.), Handbook of autism and pervasive developmental disorders (pp. 682–703). Hoboken, NJ: Wiley.
Losh, M., Childress, D., Lam, K., & Piven, J. (2008). Defining key features of the broad autism phenotype: A comparison across parents of multiple- and single-incidence autism families. American Journal of Medical Genetics B: Neuropsychiatric Genetics, 147B, 424–433.CrossRef
McEachin, J. J., Smith, T., & Lovaas, O. I. (1993). Long-term outcome for children with autism who received early intensive behavioral treatment. American Journal of Mental Retardation, 97, 359–372.PubMed
Medical Research Council. (2001). MRC review of autism research: Epidemiology and causes. London: MRC.
Mundy, P., & Burnette, C. (2005). Joint attention and neurodevelopmental models of autism. In F. Volkmar, R. Paul, A. Klin, & D. Cohen (Eds.), Handbook of autism and pervasive developmental disorders (pp. 650–681). Hoboken, NJ: Wiley.
National Research Council. (2001). Educating children with autism. Committee on educational interventions for children with autism. Washington, DC: National Academy Press.
O’Connor, N., & Hermelin, B. (1998). Annotation: Low intelligence and special abilities. Journal of Child Psychology and Psychiatry, 29, 391–396.CrossRef
Ozonoff, S., South, M., & Provencal, S. (2005). Executive functions. In F. Volkmar, R. Paul, A. Klin, & D. Cohen (Eds.), Handbook of autism and pervasive developmental disorders (pp. 606–627). Hoboken, NJ: Wiley.
Parr, J. R., Le Couteur, A., Baird, G., Rutter, M., Pickles, A., Fombonne, E., et al. (in press). Early developmental regression in autism spectrum disorder: Evidence from an international multiplex sample. Journal of Autism and Developmental Disorders. doi:10.1007/s10803-010-1055-2
Persico, A., & Bugeron, T. (2006). Searching for ways out of the autism maze: Genetic, epigenetic and environmental clues. Trends in Neuroscience, 29, 349–358.CrossRef
Pickles, A., Bolton, P., Macdonald, H., Bailey, A., Le Couteur, A., Sim, C. H., et al. (1995). Latent class analysis of recurrence risks for complex phenotypes with selection and measurement error: A family history study of autism. American Journal of Human Genetics, 57, 717–726.PubMed
Piven, J., Arndt, S., Bailey, J., Haveramp, S., Andreasen, N. C., & Palmer, P. (1995). An MRI study of brain size in autism. American Journal of Psychiatry, 152, 1145–1149.PubMed
Rutter, M. (1970). Autistic children: Infancy to adulthood. Seminars in Psychiatry, 2, 435–450.PubMed
Rutter, M. (2003). Roots of mental illness (pp. 11–21). New York: The New York Academy of Sciences.
Rutter, M. (2005b). Genetic influences and autism. In F. Volkmar, R. Paul, A. Klin, & D. Cohen (Eds.), Handbook of autism and pervasive developmental disorders (pp. 425–452). Hoboken, NJ: Wiley.
Rutter, M. (2008). Thimerosal vaccine litigation. Report to US vaccine court 2008.
Rutter, M. (in press). Child psychiatric diagnosis and classification: Concept, findings, challenges & potential. Journal of Child Psychology and Psychiatry.
Rutter, M., & Bailey, A. (1993). Thinking and relationships: Mind and brain. In S. Baron-Cohen, H. Tager-Flusberg, & D. Cohen (Eds.), Understanding other minds: Perspectives from autism (pp. 481–505). New York: Oxford University Press.
Rutter, M., Bailey, A., & Lord, C. (2003). The social communication questionnaire. Manual. Los Angeles, CA: Western Psychological Services.
Rutter, M., & Sonuga-Barke, E. J. (Eds.). (2010). Deprivation-specific psychological patterns: Effects of institutional deprivation. Monographs of the Society for Research in Child Development, 75:1. Serial no. 295.
Scahill, L., & Martin, A. (2005). Psychopharmacology. In F. Volkmar, R. Paul, A. Klin, & D. Cohen (Eds.), Handbook of autism and pervasive developmental disorders (pp. 1102–1117). Hoboken, NJ: Wiley.
Treffert, D. A. (2010). The savant syndrome: An extraordinary condition. A synopsis: Past, present, future. In F. Happé & U. Frith (Eds.), Autism and talent (pp. 1–12). New York: Oxford University Press.
Woodhouse, W., Bailey, A., Rutter, M., Bolton, P., Baird, G., & Le Couteur, A. (1996). Head circumference in autism and other pervasive developmental disorders. Journal of Child Psychology and Psychiatry, 37, 785–801.CrossRef
Yirmiya, N., & Charman, T. (2010). The prodrome of autism: Early behavioural and biological signs, regression, peri- and post-natal development and genetics. Journal of Child Psychology and Psychiatry, 5, 432–458.CrossRef
- Progress in Understanding Autism: 2007–2010
Journal of Autism and Developmental Disorders
Volume 41, Issue 4 , pp 395-404
- Cover Date
- Print ISSN
- Online ISSN
- Springer US
- Additional Links
- Scientific advances
- Research challenges
- Industry Sectors
- Author Affiliations
- 1. MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, King’s College London, PO Box 80, De Crespigny Park, Denmark Hill, London, SE5 8AF, UK