Onset Patterns Prior to 36 Months in Autism Spectrum Disorders
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The present study investigated differences among children with three different patterns of autism symptom onset: regression, plateau, and no loss and no plateau. Cross-sectional data were collected from parents of children aged 3–17 years with an autism spectrum disorder (n = 2,720) who were recruited through a US-based online research database. Parental report of developmental characteristics was assessed through a parent questionnaire, and current autism symptoms were measured via the Social Responsiveness Scale and Social Communication Questionnaire. Multivariate analyses indicated that children with regression had a distinct developmental pattern marked by less delayed early development. However, following regression, these children evinced elevated autism symptom scores and an increased risk for poorer outcomes when compared with the other onset groups.
- American Psychiatric Association (2000). Diagnostic and statistical manual of mental disorders (4th ed., text revision). Washington, DC: American Psychiatric Association.
- Bernabei, P., Cerquiglini, A., Cortesi, F., & D’Ardia, C. (2007). Regression versus no regression in the autistic disorder: Developmental trajectories. Journal of Autism and Developmental Disorders, 37, 580–588. CrossRef
- Berument, S. K., Rutter, M., Lord, C., Pickles, A., & Bailey, A. (1999). Autism Screening Questionnaire: Diagnostic validity. The British Journal of Psychiatry, 175, 444–451. CrossRef
- Chakrabari, S., & Fombonne, E. (2001). Pervasive developmental disorders in preschool children. The Journal of the American Medical Association, 285, 3093–3099. CrossRef
- Constantino, J., Davis, S., Todd, R., Schindler, M., Gross, M., Brophy, S., et al. (2003). Validation of a brief quantitative measure of autistic traits: Comparison of the Social Responsiveness Scale with the Autism Diagnostic Interview-Revised. Journal of Autism and Developmental Disorders, 33, 427–433. CrossRef
- Davidovitch, M., Glick, L., Holtzman, G., Tirosh, E., & Safir, M. P. (2000). Developmental regression in autism: Maternal perception. Journal of Autism and Developmental Disorders, 30, 113–119. CrossRef
- Goldberg, W. A., Osann, K., Filipek, P. A., Laulhere, T., Jarvis, K., Modahl, C., et al. (2003). Language and other regression: Assessment and timing. Journal of Autism and Developmental Disorders, 33, 607–616. CrossRef
- Hansen, R. L., Ozonoff, S., Krakowiak, P., Angkustsiri, K., Jones, C., et al. (2009). Regression in autism: Prevalence and associated factors in the CHARGE study. Ambulatory Pediatrics, 8, 25–31. CrossRef
- Hoshino, Y., Kaneko, M., Yashima, Y., Kumashiro, H., Volkmar, F., & Cohen, D. (1987). Clinical features of autistic children with setback course in their infancy. Japanese Journal of Child and Adolescent Psychiatry, 26, 201–212.
- Kanner, L. (1943). Autistic disturbances of affective contact. Nervous Child, 2, 217–250.
- Kobayashi, R., & Murata, T. (1998). Setback phenomenon in autism and long term prognosis. Acta Psychiatrica Scandinavia, 98, 296–303. CrossRef
- Kurita, H. (1985). Infantile autism with speech loss before the age of thirty months. Journal of the American Academy of Child and Adolescent Psychiatry, 24, 191–196. CrossRef
- Kurita, H., Kita, M., & Miyake, Y. (1992). A comparative study of development and symptoms among disintegrative psychosis and infantile autism with and without speech loss. Journal of Autism and Developmental Disorders, 22, 175–188. CrossRef
- Landa, R. J. (2008). Diagnosis of autism spectrum disorders in the first 3 years of life. Nature Clinical Practice Neurology, 4, 138–147. CrossRef
- Landa, R. J., Holman, K. C., & Garrett-Mayer, E. (2007). Social and communication development in toddlers with early and later diagnosis of autism spectrum disorders. Archives of General Psychiatry, 64, 853–864. CrossRef
- Lord, C., Shulman, C., & DiLavore, P. (2004). Regression and word loss in autistic spectrum disorders. Journal of Child Psychology and Psychiatry and Allied Disciplines, 45, 936–955. CrossRef
- Luyster, R., Richler, J., Risi, S., Hsu, W. L., Dawson, G., Bernier, R., et al. (2005). Early regression in social communication in autism spectrum disorders: A CPEA study. Developmental Neuropsychology, 27, 311–336. CrossRef
- Ozonoff, S., Heung, K., Byrd, R., Hansen, R., & Hertz-Picciotto, I. (2008). The onset of autism: Patterns of symptom emergence in the first years of life. Autism Research, 1, 320–328. CrossRef
- Pine, E., Luby, J., Abbacchi, A., & Constantino, J. N. (2006). Quantitative assessment of autistic symptomatology in preschoolers. Autism: The International Journal of Research and Practice, 10, 344–352.
- Rogers, S. J. (2004). Developmental regression in autism spectrum disorders. Journal of Mental Retardation and Developmental Disabilities Research, 10, 139–143. CrossRef
- Rogers, S. J., & DiLalla, D. (1990). Age of symptom onset in young children with pervasive developmental disorders. Journal of the American Academy of Child and Adolescent Psychiatry, 29, 863–872. CrossRef
- Short, A. B., & Schopler, E. (1988). Factors relating to age of onset in autism. Journal of Autism and Developmental Disorders, 18, 207–215. CrossRef
- Siperstein, R., & Volkmar, F. (2004). Brief report: Parental reporting of regression in children with pervasive developmental disorders. Journal of Autism and Developmental Disorders, 34, 731–734. CrossRef
- Volkmar, F. R., & Cohen, D. J. (1989). Disintegrative disorder or “late onset” autism. Journal of Child Psychiatry and Psychology, 30, 717–724. CrossRef
- Volkmar, F. R., Stier, D. M., & Cohen, D. J. (1985). Age of recognition of pervasive developmental disorder. American Journal of Psychiatry, 142, 1450–1452.
- Werner, E., Dawson, G., Munson, J., & Osterling, J. (2005). Variation in early developmental course in autism and its relation with behavioral outcome at 3–4 years of age. Journal of Autism and Developmental Disorders, 35, 337–350. CrossRef
- Wilson, S., Djukic, A., Shinnar, S., Dharmani, C., & Rapin, I. (2003). Clinical characteristics of language regression in children. Developmental Medicine and Child Neurology, 45, 508–514. CrossRef
- World Health Organization (1992). International classification of disease-10, Geneva.
- Onset Patterns Prior to 36 Months in Autism Spectrum Disorders
Journal of Autism and Developmental Disorders
Volume 40, Issue 11 , pp 1389-1402
- Cover Date
- Print ISSN
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- Springer US
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- Pervasive developmental disorders
- Onset pattern
- Industry Sectors
- Author Affiliations
- 1. Center for Autism and Related Disorders, Kennedy Krieger Institute, Baltimore, MD, USA
- 2. Department of Medical Informatics, Kennedy Krieger Institute, 3825 Greenspring Avenue, Painter Building, 1st Floor, Baltimore, MD, USA
- 3. Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
- 4. Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, USA