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Socio-Behavioral Characteristics of Children with Rubinstein-Taybi Syndrome

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Abstract

Research regarding the behavioral aspects of children with Rubinstein-Taybi syndrome (RTS) has suggested some possible behavioral patterns including autistic features. Caregivers of 39 children (mean age = 8.4 years) with RTS (49% showing abnormality in CREBBP gene) and 39 children (mean age = 8.6 years) matched on developmental level, age and gender were administered the Child Behavior Checklist and the Children’s Social Behavior Questionnaire. Children with RTS did not exhibit higher internalizing (affective and anxiety symptoms) or externalizing (disruptive symptoms) behavioral problems than expected for their age/developmental range. However, they displayed some specific behaviors: short attention span, motor stereotypies, poor coordination, and overweight. The presence of an identified CREBBP gene abnormality was possibly related to the motor difficulties through impaired motor skills learning.

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Acknowledgments

We are grateful to the patients and parents who participated in this project. We also thank the French Rubinstein-Taybi Syndrome Association.

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Authors and Affiliations

  1. Child Psychiatry Department, Centre Hospitalier Charles-Perrens, University Victor Segalen, Bordeaux 2, France

    Cédric Galéra, Sonia Fraisse, Sophie Naudion & Manuel-Pierre Bouvard

  2. Centre Hospitalier Charles-Perrens, Pôle de pédopsychiatrie universitaire, 121 rue de la Béchade, 33076, Bordeaux, France

    Cédric Galéra

  3. Department of Medical Genetics, Centre Hospitalier Pellegrin Enfant, University Victor Segalen, Bordeaux 2, France

    Emmanuelle Taupiac, Sonia Fraisse, Sophie Naudion, Eva Toussaint, Caroline Rooryck-Thambo, Marie-Ange Delrue, Benoit Arveiler & Didier Lacombe

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  1. Cédric Galéra
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  2. Emmanuelle Taupiac
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  3. Sonia Fraisse
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  4. Sophie Naudion
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  5. Eva Toussaint
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  6. Caroline Rooryck-Thambo
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  7. Marie-Ange Delrue
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  8. Benoit Arveiler
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  9. Didier Lacombe
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  10. Manuel-Pierre Bouvard
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Correspondence to Cédric Galéra.

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Galéra, C., Taupiac, E., Fraisse, S. et al. Socio-Behavioral Characteristics of Children with Rubinstein-Taybi Syndrome. J Autism Dev Disord 39, 1252–1260 (2009). https://doi.org/10.1007/s10803-009-0733-4

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  • DOI: https://doi.org/10.1007/s10803-009-0733-4

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