Journal of Autism and Developmental Disorders

, 39:188

Brief Report: Relationship Between Non-verbal IQ and Gender in Autism

Authors

  • Ryan Banach
    • Department of Family MedicineMcMaster University
  • Ann Thompson
    • Department of Psychiatry and Behavioural NeurosciencesMcMaster University
    • Department of Psychiatry and Behavioural NeurosciencesMcMaster University
    • Offord Centre for Child StudiesMcMaster University
  • Jeremy Goldberg
    • Department of Psychiatry and Behavioural NeurosciencesMcMaster University
  • Lawrence Tuff
    • Department of Psychiatry and Behavioural NeurosciencesMcMaster University
  • Lonnie Zwaigenbaum
    • Department of PediatricsUniversity of Alberta
  • William Mahoney
    • Department of PediatricsMcMaster University
Brief Report

DOI: 10.1007/s10803-008-0612-4

Cite this article as:
Banach, R., Thompson, A., Szatmari, P. et al. J Autism Dev Disord (2009) 39: 188. doi:10.1007/s10803-008-0612-4

Abstract

It has been proposed that females at risk for autism are protected in some way, so that only those with the greatest genetic liability are affected. Consequently, affected male siblings of females with autism should be more impaired than affected male siblings of male probands. One hundred and ninety-four (194) families with a single child with autism (simplex, SPX) and 154 families with more than one child with autism (multiplex, MPX) were examined on measures of severity, including non-verbal IQ. Among SPX families, girls had lower IQ than boys, but no such differences were seen among MPX families. Similarly, the affected brothers of girls with autism were no different from affected brothers of male probands. These data suggest that MPX and SPX families differ with respect to the relationship between gender and IQ.

Keywords

AutismIQGenderGenetic

Copyright information

© Springer Science+Business Media, LLC 2008