Journal of Autism and Developmental Disorders

, Volume 38, Issue 1, pp 169–175

Brief Report: Plasma Leptin Levels are Elevated in Autism: Association with Early Onset Phenotype?

Authors

  • Paul Ashwood
    • Department of Medical Microbiology and ImmunologyUniversity of California at Davis
    • The M.I.N.D. InstituteUniversity of California at Davis
    • NIEHS Center for Children’s Environmental HealthUniversity of California at Davis
  • Christina Kwong
    • Division of Rheumatology, Allergy and Clinical ImmunologyUniversity of California at Davis
    • School of MedicineRosalind Franklin University of Medicine and Science
  • Robin Hansen
    • The M.I.N.D. InstituteUniversity of California at Davis
    • NIEHS Center for Children’s Environmental HealthUniversity of California at Davis
    • Department of PediatricsUniversity of California at Davis
  • Irva Hertz-Picciotto
    • The M.I.N.D. InstituteUniversity of California at Davis
    • NIEHS Center for Children’s Environmental HealthUniversity of California at Davis
    • Department of Public Health Sciences, Division of EpidemiologyUniversity of California at Davis
  • Lisa Croen
    • NIEHS Center for Children’s Environmental HealthUniversity of California at Davis
    • Department of ResearchKaiser Permanente Northern California
  • Paula Krakowiak
    • The M.I.N.D. InstituteUniversity of California at Davis
    • NIEHS Center for Children’s Environmental HealthUniversity of California at Davis
    • Department of Public Health Sciences, Division of EpidemiologyUniversity of California at Davis
  • Wynn Walker
    • Department of NeurologyUniversity of California at Davis
  • Isaac N. Pessah
    • The M.I.N.D. InstituteUniversity of California at Davis
    • NIEHS Center for Children’s Environmental HealthUniversity of California at Davis
    • Department of Veterinary Molecular BiosciencesUniversity of California at Davis
    • The M.I.N.D. InstituteUniversity of California at Davis
    • NIEHS Center for Children’s Environmental HealthUniversity of California at Davis
    • Division of Rheumatology, Allergy and Clinical ImmunologyUniversity of California at Davis
Brief Communication

DOI: 10.1007/s10803-006-0353-1

Cite this article as:
Ashwood, P., Kwong, C., Hansen, R. et al. J Autism Dev Disord (2008) 38: 169. doi:10.1007/s10803-006-0353-1

Abstract

There is evidence of both immune dysregulation and autoimmune phenomena in children with autism spectrum disorders (ASD). We examined the hormone/cytokine leptin in 70 children diagnosed with autism (including 37 with regression) compared with 99 age-matched controls including 50 typically developing (TD) controls, 26 siblings without autism, and 23 children with developmental disabilities (DD). Children with autism had significantly higher plasma leptin levels compared with TD controls (p < .006). When further sub-classified into regression or early onset autism, children with early onset autism had significantly higher plasma leptin levels compared with children with regressive autism (< .042), TD controls (< .0015), and DD controls (p < .004). We demonstrated an increase in leptin levels in autism, a finding driven by the early onset group.

Keywords

Inflammation Leptin Autism Regression

Copyright information

© Springer Science+Business Media, LLC 2007