Journal of Autism and Developmental Disorders

, Volume 37, Issue 9, pp 1776–1786

Autistic Spectrum Disorders in Velo-cardio Facial Syndrome (22q11.2 Deletion)

  • Kevin M. Antshel
  • Alka Aneja
  • Leslie Strunge
  • Jena Peebles
  • Wanda P. Fremont
  • Kimberly Stallone
  • Nuria AbdulSabur
  • Anne Marie Higgins
  • Robert J. Shprintzen
  • Wendy R. Kates
Original paper

DOI: 10.1007/s10803-006-0308-6

Cite this article as:
Antshel, K.M., Aneja, A., Strunge, L. et al. J Autism Dev Disord (2007) 37: 1776. doi:10.1007/s10803-006-0308-6

Abstract

The extent to which the phenotype of children comorbid for velocardiofacial syndrome (VCFS) and autism spectrum disorders (ASD) differs from that of VCFS-only has not been studied. The sample consisted of 41 children (20 females) with VCFS, ranging in age from 6.5 years to 15.8 years. Eight children with VCFS met formal DSM-IV diagnostic criteria for autism based upon the ADI-R. These eight plus an additional nine participants met diagnostic criteria for an autistic spectrum disorder (VCFS + ASD). Ninety-four percent of the children with VCFS + ASD had a co-occurring psychiatric disorder while 60% of children with VCFS had a psychiatric disorder. Children with VCFS + ASD had larger right amygdala volumes. All other neuroanatomic regions of interest were statistically similar between the two groups.

Keywords

Velocardiofacial syndrome22q11.2 deletionAutism spectrum disorderAmygdala

Copyright information

© Springer Science+Business Media, LLC 2006

Authors and Affiliations

  • Kevin M. Antshel
    • 1
  • Alka Aneja
    • 1
  • Leslie Strunge
    • 2
  • Jena Peebles
    • 1
  • Wanda P. Fremont
    • 1
  • Kimberly Stallone
    • 1
  • Nuria AbdulSabur
    • 1
  • Anne Marie Higgins
    • 1
  • Robert J. Shprintzen
    • 1
  • Wendy R. Kates
    • 1
    • 3
  1. 1.State University of New York - Upstate Medical UniversitySyracuseUSA
  2. 2.Kennedy Krieger InstituteBaltimoreUSA
  3. 3.Johns Hopkins University School of MedicineBaltimoreUSA