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The effects of topical carbonic anhydrase inhibitor in treatment of nystagmus

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Abstract

Objective

To evaluate the effects of topical carbonic anhydrase inhibitor (CAI), brinzolamide (Azopt), for treatment of nystagmus patients.

Materials and methods

Patients who used Brinzolamide for treatment of nystagmus were retrospectively analyzed. 23 patients were included in this study. The patients’ diagnosis were idiopathic infantile nystagmus 18 (78.2%) and oculocutaneous albinism in 5 (21.8%). Azopt eye drop was used in both eyes, 3 times a day. Detailed eye examination in all of the patients before treatment and repeated at the end of the first week after treatment. SPSS 16.0 computer program was used for evaluation of DATAs.

Results

The mean follow-up was 32 ± 28 months. 23 patients 15 (65.2%) were male and 8 (34.7%) were female and the mean age was 12.6 ± 5.5. Before the management of topical brinzolamide, abnormal head position (AHP) were observed in 18 patients. After that we found reduction of nystagmus in 5 (22.7%) of the patients, increase in vision in 9 (40.9%) and reduced AHP in 18.3%. There is no identified change in 4 (18.1%).

Conclusion

The medical treatment of nystagmus with topical brinzolamide was found effective in our series but, wider series and longer follow-up studies are needed.

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References

  1. Brodsky MC, Dell’Osso LF (2014) A unifying neurologic mechanism for infantile nystagmus. JAMA Ophthalmol 132(6):761–768

    Article  PubMed  Google Scholar 

  2. Chung ST, Bedell HE (1996) Velocity criteria for “foveation periods” determined from image motions simulating congenital nystagmus. Optom Vis Sci 73(2):92–103

    Article  CAS  PubMed  Google Scholar 

  3. Sarvananthan N, Surendran M, Roberts EO, Jain S, Thomas S, Shah N, Proudlock FA, Thompson JR, McLean RJ, Degg C, Woodruff G, Gottlob I (2009) The prevalence of nystagmus: the Leicestershire nystagmus survey. Invest Ophthalmol Vis Sci 50(11):5201–5206

    Article  PubMed  Google Scholar 

  4. Yo C, Demer JL (1992) Two-dimensional optokinetic nystagmus induced by moving plaids and texture boundaries. Evidence for multiple visual pathways. Invest Ophthalmol Vis Sci 33(8):2490–2500

    CAS  PubMed  Google Scholar 

  5. Chung ST, LaFrance MW, Bedell HE (2011) Influence of motion smear on visual acuity in simulated infantile nystagmus. Optom Vis Sci 88(2):200–207

    Article  PubMed  PubMed Central  Google Scholar 

  6. Skavenski AA, Blair SM, Westheimer G (1981) The effect of habituating vestibular and optokinetic nystagmus on each other. J Neurosci 1(4):351–357

    CAS  PubMed  Google Scholar 

  7. Weiss AH, Biersdorf WR (1989) Visual sensory disorders in congenital nystagmus. Ophthalmology 96:517–523

    Article  CAS  PubMed  Google Scholar 

  8. Sarvananthan N, Surendran M, Roberts EO et al (2009) The prevalence of nystagmus: the Leicestershire nystagmus survey. Invest Ophthalmol Vis Sci 50:5201–5206

    Article  PubMed  Google Scholar 

  9. Cvetkovic RS, Perry CM (2003) Brinzolamide: a review of its use in the management of primary open-angle glaucoma and ocular hypertension. Drugs Aging 20:919–947

    Article  CAS  PubMed  Google Scholar 

  10. Hertle RW, Dell’Osso LF, FitzGibbon EJ, Yang D, Mellow SD (2004) Horizontal rectus muscle tenotomy in children with infantile nystagmus syndrome: a pilot study. J AAPOS 8:539–548

    Article  PubMed  Google Scholar 

  11. Stewart-Brown SL, Haslum MN (1988) Partial sight and blindness in children of the 1970 birth cohort at 10 years of age. J Epidemiol Community Health 42(1):17–23

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Abadi RV, Bjerre A (2002) Motor and sensory characteristics of infantile nystagmus. Br J Ophthalmol 86(10):1152–1160

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Forssman B, Ringner B (1971) Prevalence and inheritance of congenital nystagmus in a Swedish population. Ann Hum Genet 35(2):139–147

    Article  CAS  PubMed  Google Scholar 

  14. Abadi RV, Pascal E (1989) The recognition and management of albinism. Ophthal Physiol Opt 9:3–15

    Article  CAS  Google Scholar 

  15. Dell’Osso LF, Daroff RB (1975) Congenital nystagmus waveforms and foveation strategy. Doc Ophthalmol 39(1):155–182

    Article  PubMed  Google Scholar 

  16. Kerrison JB, Giorda R, lenart TD, Drack AV, Maumenee IH (2001) Clinical and genetic analysis of a family with X-linked congenital nystagmus (NYS1). Ophthalmic Genet 22:241–248

    Article  CAS  PubMed  Google Scholar 

  17. Büttner-Ennever JA, Horn AKE, Graf W et al (2002) Modern concepts of brainstem anatomy. From extraocular motoneurons to proprioceptive pathways. In: Kaminski HJ, Leigh RJ (eds) Neurobiology of eye movements. From molecules to behavior—Ann NY Acad Sci, vol 956. NYAS, New York, pp 75–84

    Google Scholar 

  18. CEMAS Working Group (2001) A National Eye Institute-Sponsored Workshop and Publication on The Classification of Eye Movement Abnormalities and Strabismus (CEMAS). In: The National Eye Institute Publications (see www.nei.nih.gov). National Institutes of Health, National Eye Institute, Bethesda, MD

  19. Dell’Osso LF, Traccis S, Abel LA et al (1988) Contact lenses and congenital nystagmus. Clin Vis Sci 3:229–232

    Google Scholar 

  20. Dell’Osso LF, Leigh RJ, Daroff RB (1991) Suppression of congenital nystagmus by cutaneous stimulation. Neuro Ophthalmol 11:173–175

    Article  Google Scholar 

  21. Dell’Osso LF, Hertle RW, Williams RW (1999) A new surgery for congenital nystagmus: effects of tenotomy on an achiasmatic canine and the role of extraocular proprioception. J AAPOS 3:166–182

    Article  PubMed  Google Scholar 

  22. Dell’Osso LF, Jacobs JB (2002) An expanded nystagmus acuity function: intra- and intersubject prediction of best-corrected visual acuity. Doc Ophthalmol 104:249–276

    Article  PubMed  Google Scholar 

  23. Golubovic S, Marjanovic S, Cvetkovic D et al (1989) The application of hard contact lenses in patrients with congenital nystagmus. Fortschr Ophthalmol 86:535–539

    CAS  PubMed  Google Scholar 

  24. Du JW, Schmid KL, Bevan JD, Frater KM, Ollett R, Hein B (2005) Retrospec-tive analysis of refractive errors in children with vision impairment. Optom Vis Sci 82(9):807–816

    Article  PubMed  Google Scholar 

  25. Castronuovo S, Simon JW, Kandel GL, Morier A, Wolf B, Witkop CJ et al (1991) Variable expression of albinism within a single kindred. Am J Ophthalmol 111:419–426

    Article  CAS  PubMed  Google Scholar 

  26. Comer RM, Dawson EL, Lee JP (2006) Baclofen for patients with congenital periodic alternating nystagmus. Strabismus 14(4):205–209

    Article  CAS  PubMed  Google Scholar 

  27. Hernández-García E, Gómez-De-Liaño-Sánchez R (2012) Use of botulinum toxin in a patient with pendular congenital nystagmus. Arch Soc Esp Oftalmol 87(10):330–332

    Article  PubMed  Google Scholar 

  28. Hertle RW, Yang D, Adkinson T, Reed M (2015) Topical brinzolamide (Azopt) versus placebo in the treatment of infantile nystagmus syndrome (INS). Br J Ophthalmol 99(4):471–476

    Article  PubMed  Google Scholar 

  29. Dell’osso LF, Hertle RW, Leigh RJ, Jacobs JB, King S, Yaniglos S (2011) Effects of topical brinzolamide on infantile nystagmus syndrome waveforms: eyedrops for nystagmus. J Neuroophthalmol 31(3):228–233

    PubMed  Google Scholar 

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Acknowledgements

This study was conducted in accordance with Institutional Review Board regulations and with the principles of the Declaration of Helsinki.

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Authors and Affiliations

  1. Beyoglu Eye Training and Research Hospital, Bereketzade Cami Sokak No:2 Beyoglu, Istanbul, Turkey

    Ebru Demet Aygit, Osman Bulut Ocak, Aslı İnal, Korhan Fazıl, Serpil Akar & Birsen Gokyigit

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  1. Ebru Demet Aygit
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  2. Osman Bulut Ocak
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  3. Aslı İnal
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Correspondence to Ebru Demet Aygit.

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Aygit, E.D., Ocak, O.B., İnal, A. et al. The effects of topical carbonic anhydrase inhibitor in treatment of nystagmus. Int Ophthalmol 38, 265–269 (2018). https://doi.org/10.1007/s10792-017-0456-z

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  • DOI: https://doi.org/10.1007/s10792-017-0456-z

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