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New concepts in the appraisal and management of birdshot retinochoroiditis, a global perspective

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Abstract

Birdshot retinochoroiditis (BRC) is a relatively recently described entity. BRC uveitis is predominant in the posterior segment with dual, independent retinal, and choroidal inflammation. The disease has no known extra-ocular inflammation sites and yet features the strongest known HLA association: HLA-A29 is present in close to 100 % of cases. Aim in this mini-review was to readjust the appraisal of BRC in the light of a global approach including the full array of investigational procedures. Historical background and the genesis of the disease name were searched. Global disease description including both the retina and the choroid was given. Retinal involvement was clearly characterized, pointing toward the profuse leakage of retinal vessels of all sizes in early disease and widespread atrophy in under treated patients. The importance of exploration of choroidal disease, unavailable until the early 1990s before the advent of indocyanine green angiography (ICGA) was stressed, allowing early diagnosis of disease. Despite its proven importance to explore the choroid, ICGA is still sparsely used. Existing diagnostic criteria were found to be clearly inappropriate not allowing early diagnosis and are in need to be revised, taking into account both retinal and choroidal aspects of the disease, in order to make early diagnosis possible and hence allow proper management .

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Authors and Affiliations

  1. Retinal and Inflammatory Eye Disease, Centre for Ophthalmic Specialized Care (COS), Clinic Montchoisi, Rue Charles-Monnard 6, 1003, Lausanne, Switzerland

    Marina Papadia & Carl P. Herbort Jr.

  2. Ospedale Padre Antero Micone Genova, Genova, Italy

    Marina Papadia

  3. University of Lausanne, Lausanne, Switzerland

    Carl P. Herbort Jr.

Authors
  1. Marina Papadia
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  2. Carl P. Herbort Jr.
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Correspondence to Carl P. Herbort Jr..

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Papadia, M., Herbort, C.P. New concepts in the appraisal and management of birdshot retinochoroiditis, a global perspective. Int Ophthalmol 35, 287–301 (2015). https://doi.org/10.1007/s10792-015-0046-x

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  • DOI: https://doi.org/10.1007/s10792-015-0046-x

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