Skip to main content

Advertisement

Log in

Orbital schwannoma: a clinicopathologic study

  • Original Paper
  • Published:
International Ophthalmology Aims and scope Submit manuscript

Abstract

The aim of the study was to study the clinical, radiological and histopathological characteristics of orbital schwannomas. It is a retrospective study conducted at a tertiary eye care hospital. A review of histopathological records of the orbital tumors operated between 1993 and 2011 was done. The clinical, imaging and histopathological details of cases of orbital schwannoma were analyzed. Forty-nine cases of orbital schwannomas identified. The age ranged from 8 to 65 years with a female preponderance. The median duration of symptoms was 3 years. Computed tomography findings varied from a hypodense to hyperdense lesion with nil to marked contrast enhancement. USG demonstrated a defined lesion with variable internal reflectivity. Varied proportions of Antoni A and Antoni B areas were found on histopathology of the masses. Hypodense or cystic areas on imaging significantly correlated with Antoni B areas on histopathology. Orbital schwannoma is a rare tumor. The incidence of schwannoma in our institution is 6.5 %. Variable imaging features were found. The definite diagnosis can be established on the basis of histopathological and immunohistochemical studies.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Albert DM, Jakobeic FA (2000) Principles and practice of ophthalmology, 2nd edn. WB Saunders, Philadelphia

    Google Scholar 

  2. Kashyap S, Pushker N, Meel R et al (2009) Orbital schwannoma with cystic degeneration. Clin Exp Ophthalmol 37:293–298

    Article  Google Scholar 

  3. Rootman J, Goldberg C, Robertson W (1982) Primary orbital schwannomas. Br J Ophthalmol 66:194–204

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  4. Cantore G, Ciappetta P, Raco A, Lunardi P (1986) Orbital schwannomas: report of nine cases and review of the literature. Neurosurgery 19:583–588

    Article  CAS  PubMed  Google Scholar 

  5. Rose GE, Wright JE (1991) Isolated peripheral nerve sheath tumors of the orbit. Eye 5:668–673

    Article  PubMed  Google Scholar 

  6. Wang Y, Xiao LH (2008) Orbital schwannomas: findings from magnetic resonance imaging in 62 cases. Eye 22:1034–1039

    Article  CAS  PubMed  Google Scholar 

  7. Cockerham KP, Cockerham GC, Stutzman R et al (1999) The clinical spectrum of schwannomas presenting with visual dysfunction: a clinicopathologic study of three cases. Surv Ophthalmol 44:226–234

    Article  CAS  PubMed  Google Scholar 

  8. Pushker N, Meel R, Sharma S, Bajaj MS, Kashyap S, Sen S (2011) Giant orbital schwannoma with fluid–fluid levels. Br J Ophthalmol 95(1168):1180–1181

    Google Scholar 

  9. Betharia SM, Sharma V, Pushker N (2003) Ultrasound findings in orbital hydatid cysts. Am J Ophthalmol 135:568–570

    Article  CAS  PubMed  Google Scholar 

  10. Gunduz K, Shields CL, Gunalp I, Erden E, Shields JA (2003) Orbital schwannoma: correlation of magnetic resonance imaging and pathologic findings. Graefe’s Arch Clin Exp Ophthalmol 241:593–597

    Article  Google Scholar 

  11. Byrne BM, van Heuven WAJ, Lawton AW (1988) Echographic characteristics of benign orbital schwannomas (neurilemomas). Am J Ophthalmol 106:194–198

    Article  CAS  PubMed  Google Scholar 

  12. Xiao LH, Lu XZ, Wang Y, Yang XJ, Hei Y, Zhu H (2006) Retrospective analysis of diagnosis and treatment of the orbital neurilemomas. Zhonghua Yan Ke Za Zhi 42:585–589

    PubMed  Google Scholar 

  13. Subramanian N, Rambhatia S, Mahesh L et al (2005) Cystic schwannoma of the orbit—a case series. Orbit 24:125–129

    Article  PubMed  Google Scholar 

  14. Jadro-Santel D, Markovic S, Besenski N, Kalousek M (1991) Correlative tissue pathology of intracranial neurinomas with computed tomography scans. Neurol Croat 40:13–22

    CAS  PubMed  Google Scholar 

  15. Kiratli H, Erkan K, Soylemezoglu F (2007) Solitary orbital schwannomas: clinical, imaging, and surgical features. J Fr Ophthalmol 30:986–991

    Article  CAS  Google Scholar 

  16. Butt ZA, McNab AA (1998) Orbital neurilemmoma: report of seven cases. J Clin Neurosci 5:390–393

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgments

None.

Conflict of interest

None.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Seema Kashyap.

Additional information

One of the cases has been already published in British Journal of Ophthalmology [8].

A subset of patients included in this series has been published earlier in Clinical and Experimental Ophthalmology [2].

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Pushker, N., Khurana, S., Kashyap, S. et al. Orbital schwannoma: a clinicopathologic study. Int Ophthalmol 35, 481–486 (2015). https://doi.org/10.1007/s10792-014-9973-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10792-014-9973-1

Keywords

Navigation