Skip to main content
SpringerLink
Log in

Analgesic and anti-inflammatory effect of aqueous extract of the stem bark of Allanblackia gabonensis (Guttiferae)

  • Research Article
  • Published:
Inflammopharmacology Aims and scope Submit manuscript

Abstract

Allanblackia gabonensis (Guttiferae) is a plant used in the African traditional medicine as remedies against pain, rheumatism, inflammations. In the present work, the analgesic effect of aqueous extract has been evaluated using acetic acid, formalin, hot-plate test, tail immersion and paw-pressure test. The anti-inflammatory effect of this extract was also investigated on carrageenan, histamine or serotonin induced by paw oedema. Aqueous extract of stem bark of A. gabonensis administrated p.o. showed significant activity against paw oedema induced by carrageenan, with a maximum percentage of inhibition reaching the 74.01% at the preventive test at a dose of 200 mg/kg. A. gabonensis exhibited a significant reduction of paw oedema induced by both histamine and serotonin with a maximal inhibition of 56.94% (200 mg/kg) and 40.83% (100 mg/kg), respectively. It showed significant protective effects against chemical stimuli (acetic acid and formalin) in the mouse. Administered orally at the doses of 100–400 mg/kg, exhibited protective effect of at least 69.78% on the pain induced by acetic acid and also reduced first (67.18% at 200 mg/kg) and second (83.87% at 400 mg/kg) phase of pain-induced par formalin. It also produced a significant increase of the threshold of sensitivity to pressure and hot plate-induced pain in the rats. These results suggest a peripheral and central analgesic activities as well as an anti-inflammatory effect of the stem bark of A. gabonensis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  • Asongalem EA, Foyet HS, Ngogang J et al (2004) Analgesic and anti inflammatory activities of Erigeron floribundeus. J Ethnopharmacol 91:301–308

    Article  PubMed  CAS  Google Scholar 

  • Aydin S, Demir T, Ozturk Y et al (1999) Analgesic activity of Nepeta italica L. Phytother Res 13:20–23

    Article  PubMed  CAS  Google Scholar 

  • Azebaze AGB, Meyer M, Bodo B et al (2004) A new polyisoprenylated xanthones from the stem bark of Allanblackia monticola. Phytochemistry 65:2789–2795

    Article  PubMed  Google Scholar 

  • Azebaze AGB, Meyer M, Valentin A et al (2006) Prenylated xanthone derivatives with activity from Allanblackia monticola Staner L.C. Chem Pharm Bull 54:111–113

    Article  PubMed  CAS  Google Scholar 

  • Azebaze AGB, Ouahouo BMW, Vardamides JC, Valentin A, Kuete V, Acebey L, Beng VP, Nkengfack AE, Meyer M (2008) Antimicrobial and antileishmanial xanthones from the stem bark of Allanblackia gabonensis Chem Nat Comp 44:582–587

    Google Scholar 

  • Bamps P (1970) Flore du Congo, Rwanda et Burundi, Spermaphytes Guttiferae 40

  • Bentley GA, Newtown SH, Starr J (1999) Analgesic activity of Nepeta italica L. Phytother Res 13:20–23

    Article  Google Scholar 

  • Covino BG, Dubner R, Gybels J et al (1980) IASP committee for research and ethical issues ethical standards for investigations of experimental pain in animals. Pain 9:141143

    Google Scholar 

  • Deraedt R, Jougney S, Benzoni J et al (1980) Release of prostaglandins E and F in algogenic reaction and its inhibition. Eur J Pharmacol 61:17–24

    Article  PubMed  CAS  Google Scholar 

  • Dongmo AB, Salah M, Kamanyi A et al (2003) Anti-inflammatory and analgesic properties of the stem bark extract of Mitragyna ciliata in rats. J Ethnopharmacol 84:17–21

    Article  PubMed  CAS  Google Scholar 

  • Dongmo AB, Salah M, Kamanyi A et al (2004) Vasodilating properties of the stem bark extract of Mitragyna ciliata in rats and guinea pigs. Phytother Res 18:36–39

    Article  PubMed  CAS  Google Scholar 

  • Dongmo AB, Ngueefack TB, Lacaille-Doubois MA (2005) Anti-nociceptive and anti-inflammatory activities of Acacia pennata Wild (Mimosaceae). J Ethnopharmacol 98:201–206

    Article  PubMed  CAS  Google Scholar 

  • Fung HB, Kirschenbaun HL (1999) Selective cyclooxygenase-2 inhibitors for the treatment of arthritis. Clin Ther 221:1131–1157

    Article  Google Scholar 

  • Gaertner M, Muller L, Roos JF, Cani G, Santos ARS, Niero R, Calixto JB, Yunes RA, Delle Manache F, Cechinel-Filho V (1999) Analgesic triterpenes from Sebastiania schottiana roots. Phytomedicine 6:41–44

    Article  PubMed  CAS  Google Scholar 

  • Garcia MD, Fernandez MA, Alvarez A, Saenz MT (2004) Antinociceptive and anti-inflammatory effect of the aqueous extract from leaves of Pimento racemosa var. ozua (Mimosaceae). J Ethnopharmacol 91:69–73

    Article  PubMed  CAS  Google Scholar 

  • Geetha T, Varalakshmi P (2001) Anti-inflammatory activity of lupeol and linoleate in rats. J Ethnopharmacol 76:77–80

    Article  PubMed  CAS  Google Scholar 

  • Ghosh MN, Singh H (1974) Inhibitory effect of a pyrrolizine alkaloid, crotalaburnine, on rat paw oedema and cotton pellet granuloma. Br J Pharmacol 51:503–508

    Article  PubMed  CAS  Google Scholar 

  • Insel PA (1996) Analgesic, antipyretic and ant-inflammatory agents and drugs employed in the treatment of gout. In: Hardman JG, Limbord LE (eds) Mcgraw-Hill, New york. pp 617–657

  • Jain NK, Kulkami SK, Singh A (2001) Role of cysteinyl leukotrienes in nociceptive and inflammatory conditions in experimental animals. Eur J Pharmacol 415:85–94

    Article  Google Scholar 

  • Knoll J (1967) Screening and grouping of psychopharmacological agents. In: Siegler PE, Mover HJ (eds) Animal and clinical pharmacologic techniques in drug evaluation. Yearbook Med. Publishers. Inc, Chicago, pp 305–321

    Google Scholar 

  • Koster R, Anderson M, De Beer J (1959) Acetic acid for analgesic screening. Fed Proceed 18:412–417

    Google Scholar 

  • Lanhers MC, Fleurentin J, Dorfman P et al (1991) Analgesic, antipyretic and anti-inflammatory properties of Euphorbia hirta. Planta Med 57:225–231

    Article  PubMed  CAS  Google Scholar 

  • Murray CW, Porreca F, Cowan A (1988) Methodological refinement in the mouse paw formalin test: an animal model of tonic pain. J Ethnopharmacol Methods 20:175–186

    Article  CAS  Google Scholar 

  • Nguemfo EA, Dimo T, Azebaze AGB et al (2007) Anti-inflammatory and antinociceptive activities of the stem bark extracts from Allanblackia monticola STANER L.C. (Guttiferae). J Ethnopharmacol 114:417–424

    Article  PubMed  Google Scholar 

  • Parma NS, Ghosh MN (1978) Anti-inflammatory activity of gossypin a bioflavanoid isolated from Hibiscus vitifolius Linn. Ind J Pharmacol 10:277–293

    Google Scholar 

  • Periaayagam JB, Sharma SA, Pillai KK (2006) Anti-inflammatory activity of Trichodesma indicun root extract in experimental animal. J Ethnopharmacol 104:410–414

    Article  Google Scholar 

  • Randall LO, Selitto JJ (1957) A method for measurement of analgesic activity on inflamed tissue. Arch Int Pharmacodyn 61:409–419

    Google Scholar 

  • Sayyah M, Hadidi N, Kamalinejad M (2004) Analgesic and anti-inflammatory activity of Lactuca sativa seed extract in rats. J Ethnopharmacol 92:325–329

    Article  PubMed  Google Scholar 

  • Schowb M, Dubost MC (1984) Entendre la douleur. Pharmapost, RC Montargis, p 99

    Google Scholar 

  • Shalheen HM, Badreldin HA, Alquarawi AA et al (2000) Effect of Psidium guajava leaves on some aspects of the central nervous system in mice. Phytother Res 14:107–111

    Article  Google Scholar 

  • Singh G, Ramey DR, Shi H et al (1996) Gastrointestinal tract complications of non-steroidal anti-inflammatory drug treatment in rheumatoid arthritis. Arch Intern Med 156:1530–1537

    Article  PubMed  CAS  Google Scholar 

  • Spereni E, Cervellati R, Innocenti G et al (2005) Anti-inflammatory, anti-nociceptive and antioxidant activities of Halanites aegyptica (L) Delile. J Ethnopharmacol 98:117–125

    Article  Google Scholar 

  • Stai HY, Chen YF, Wu TS (1995) Anti-inflammatory and analgesic activities of extract from roots of Angelica pubescens. Planta Med 61:1–8

    Article  Google Scholar 

  • Tjolsen A, Berge DG, Hunskaar S et al (1992) Popular medicine of the central plateau of Haiti-2. Ethnopharmacological inventory. J Ethnopharmacol 17:13–30

    Google Scholar 

  • Winter CA, Risley EA, Nuss GW (1962) Carrageenan-induced oedema in hind paw of rat: an assay for anti-inflammatory drugs. Proc Soc Exp Biol Med 111:544–547

    Google Scholar 

  • Zhang J, Cuzzucrea S (2000) GP16150, a poly adp-ribose polymerase inhibitor, exhibits an anti-inflammatory effect in at models of inflammatory. Auton Neurosci Basic Clin 85:141–147

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Animal Biology, Laboratory of Animal physiology, Faculty of Science, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon

    Edwige V. Ymele & Théophile Dimo

  2. Department of Animal Biology and Physiology, Laboratory of Animal Physiology, Faculty of Science, University of Douala, P.O. Box. 24157, Douala, Cameroon

    A. Bertrand Dongmo

Authors
  1. Edwige V. Ymele
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. Bertrand Dongmo
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Théophile Dimo
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Théophile Dimo.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ymele, E.V., Dongmo, A.B. & Dimo, T. Analgesic and anti-inflammatory effect of aqueous extract of the stem bark of Allanblackia gabonensis (Guttiferae). Inflammopharmacol 21, 21–30 (2013). https://doi.org/10.1007/s10787-011-0096-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10787-011-0096-2

Keywords

Search

Navigation