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Anti-inflammatory Role of Pilose Antler Peptide in LPS-Induced Lung Injury

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Abstract

The present study was designed to investigate the effects of pilose antler peptide (PAP) on lipopolysaccharide (LPS)-induced lung injury. BalB/c mice intraperitoneally received PAP (10 and 20 mg/kg) or dexamethasone (2 mg/kg) 1 h prior to intratracheal instillation of LPS. PAP significantly decreased lung wet-to-dry weight (W/D) ratio and lung myeloperoxidase (MPO) activity and restored LPS-induced lung histopathological changes. PAP also increased super oxide dismutase (SOD) level and inhibited malondialdehyde (MDA) content and levels of pro-inflammatory cytokines including tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) in bronchoalveolar lavage fluid (BALF) in LPS-stimulated mice. Furthermore, we demonstrated that PAP inhibited Rho/NF-κB pathway in LPS-induced mice. Our experimental results indicated that the protective mechanism of PAP might be attributed partly to the inhibition of Rho/NF-κB pathway.

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Authors and Affiliations

  1. Central Laboratory, Nanjing Municipal Hospital of T.C.M, The Third Affiliated Hospital of Nanjing University of T.C.M, Nanjing, 210001, China

    Chunhua Ma & Hongyan Long

  2. The First Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, 130117, China

    Chunhui Yang, Wenjun Cai & Wenhai Zhao

  3. Changchun University of Chinese Medicine, Changchun, 130117, China

    Tianzhu Zhang

Authors
  1. Chunhua Ma
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  2. Hongyan Long
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  3. Chunhui Yang
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  4. Wenjun Cai
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  5. Tianzhu Zhang
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  6. Wenhai Zhao
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Correspondence to Hongyan Long or Tianzhu Zhang.

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Ma, C., Long, H., Yang, C. et al. Anti-inflammatory Role of Pilose Antler Peptide in LPS-Induced Lung Injury. Inflammation 40, 904–912 (2017). https://doi.org/10.1007/s10753-017-0535-3

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  • DOI: https://doi.org/10.1007/s10753-017-0535-3

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