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Methyl-CpG-Binding Protein 2 (MECP2) Polymorphism in Iranian Patients with Systemic Lupus Erythematosus

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Abstract

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease which involves many organs and presents with various symptoms. It has been shown that genetic and environmental factors play a major role in this disease and may affect the onset, activity, damage, and mortality of the disease. According to recent studies, methyl-CpG-binding protein 2 (MECP2) has been associated with SLE in various populations. Herein, we studied MECP2 polymorphism in Iranian lupus patients and controls. The study included a total of 884 samples of Iranian ancestry (492 independent SLE patients and 392 unrelated healthy controls). Healthy controls were gender-, ethnic-, and age-matched with the patients. Patient and control samples were genotyped for rs1734787, rs1734791, rs1734792, and rs17435 by applying the Allelic Discrimination Real-Time PCR System. Our results showed a significant association between rs1734787 and rs1734791 SNPs and the risk of SLE in the Iranian population (p = 0.028, p = 0.028), but did not show any significant association with rs1734792 and rs17435 SNPs (p = 075, p = 0.75). The rs1734787 C and the rs1734791 T allele frequencies in the patients were significantly higher than the control group (p = 0.014, p = 0.012). In addition, a significant CTAT haplotype frequency was observed in cases with SLE (p = 0.012), and a significant AAAT haplotype frequency was observed in the control group (p = 0.0003). However, there was no significant association between genotype frequencies and SLE patients. Also, there was no significant association between these SNPs and clinical features. The result of this study suggests that polymorphism in the MECP2 locus is associated with the susceptibility of Iranian SLE patients.

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Acknowledgments

This work was supported by a research grant (grant number 93-01-30-24094) from the Deputy of Research, Tehran University of Medical Sciences, Tehran, Iran.

Declaration of conflict of interest

The author declares that they have no competing interests.

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Authors and Affiliations

  1. Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran

    Samira Alesaeidi, Jafar Karami, Mahdi Mahmoudi, Mahmoud Akbarian, Shiva Poursani, Azadeh Amirzadeh, Nazgol-Sadat Haddadi, Elahe Saffari & Ahmad Reza Jamshidi

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  1. Samira Alesaeidi
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  2. Jafar Karami
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  3. Mahdi Mahmoudi
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  4. Mahmoud Akbarian
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Correspondence to Mahdi Mahmoudi or Ahmad Reza Jamshidi.

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Alesaeidi, S., Karami, J., Mahmoudi, M. et al. Methyl-CpG-Binding Protein 2 (MECP2) Polymorphism in Iranian Patients with Systemic Lupus Erythematosus. Inflammation 38, 2185–2190 (2015). https://doi.org/10.1007/s10753-015-0201-6

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  • DOI: https://doi.org/10.1007/s10753-015-0201-6

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