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Downregulation of T Cell Immunoglobulin and Mucin Protein 3 in the Pathogenesis of Intracranial Aneurysm

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Abstract

Evidence has shown that inflammation acts as a critical contributor to the pathogenesis of intracranial aneurysm (IA), a potentially devastating clinical problem. T cell immunoglobulin and mucin protein 3 (Tim-3) is a negative regulatory molecule and plays important roles in the inflammation process. In the current study, we investigated the expression of Tim-3 and its correlation with tumor necrosis factor alpha (TNF-α) in IA patients. Data showed that both messenger RNA (mRNA) level and protein level of Tim-3 were significantly decreased in CD4+ T cells and CD8+ T cells from IA patients than from healthy controls (P < 0.001). However, expression of Tim-3 was not altered in monocytes between patients and healthy donors. Further analyses revealed that patients with ruptured aneurysm had significantly lower level of Tim-3 in CD8+ T cells than those with un-ruptured aneurysm. In addition, a negative correlation between serum level of TNF-α and the expression of Tim-3 in CD4+ T cells was observed in IA patients. Similar correlation was also identified in CD8+ T cells from IA patients. Our study suggests that Tim-3 may participate in the development and progression of IA by probably its negative regulation on TNF-α.

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Correspondence to Guo-Biao Liang.

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Hai-Feng Zhang and Ming-Guang Zhao contributed equally to this work.

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Zhang, HF., Zhao, MG., Liang, GB. et al. Downregulation of T Cell Immunoglobulin and Mucin Protein 3 in the Pathogenesis of Intracranial Aneurysm. Inflammation 38, 368–374 (2015). https://doi.org/10.1007/s10753-014-0040-x

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