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Is the IL-10 Promoter Polymorphism at Position -592 Associated with Immune System-Related Diseases?

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Abstract

Immune responses are the main causes of immune system-related diseases such as hypersensitivities and autoimmunity. It has also been established that cytokines play key roles in the regulation of immune responses which have been shown to be important in the pathogenesis of the diseases. IL-10, the main anti-inflammatory cytokine, is produced by several immune cells such as T regulatory and Th2 lymphocytes, activated macrophages, B regulatory lymphocytes as well as other cell types. It plays a key role in the regulation of immune responses after microbe elimination (homeostasis) and against self-antigens to prevent hypersensitivity and autoimmune diseases, respectively. Studies showed that a single nucleotide polymorphism (SNP) at the -592 position of IL-10 is associated with its regulation of expression. This review addresses the recent information regarding the association of the polymorphism at position -592 of IL-10 with immune-related diseases including type 2 diabetes with and without nephropathy, multiple sclerosis, and asthma with an emphasize on Iranian patients.

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Acknowledgments

The authors of this article would also like to thank Dr. Hassanshahi, as the head of Molecular Medicine Research Center, and Dr Jafarzadeh, as the head of Immunology department of Rafsanjan University of Medical Sciences, for their warm support in helping to write this review article. This project was supported by a grant from the Rafsanjan University of Medical Sciences.

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Authors and Affiliations

  1. Molecular Medicine Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran

    Mojgan Noroozi Karimabad & Gholamhossein Hassanshahi

  2. Department of Microbiology, Hematology and Immunology, Faculty of Medicine and Immunology of Infectious Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran

    Mohammad Kazemi Arababadi

  3. Immunology of Infectious Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran

    Mohammad Kazemi Arababadi

  4. Physiology and Pharmacology Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran

    Elham Hakimizadeh

  5. Department of Biochemistry, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran

    Hassan Yousefi Daredori & Mahmood Nazari

  6. School of Biomolecular and Physical Science, Eskitis Institute for Cell and Molecular Therapies, Griffith University Nathan, Queensland, Australia

    Derek Kennedy

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  1. Mojgan Noroozi Karimabad
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Correspondence to Mohammad Kazemi Arababadi.

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Karimabad, M.N., Arababadi, M.K., Hakimizadeh, E. et al. Is the IL-10 Promoter Polymorphism at Position -592 Associated with Immune System-Related Diseases?. Inflammation 36, 35–41 (2013). https://doi.org/10.1007/s10753-012-9517-7

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