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Increased expression of actin filament-stabilizing protein tropomyosin after rat traumatic brain injury

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Abstract

Tropomyosin (TM), is a coiled-coil dimmer which modulates actin filament properties, has been implicated in the control of actin filament dynamics during cell migration, morphogenesis, and cytokinesis. However, the expressions and possible functions of tropomyosin in central nervous system (CNS) lesion remain unknown. In this study, we found the expression of tropomyosin gradually increased in rat brains subjected to traumatic brain injury (TBI). Double immunofluorescence staining showed tropomyosin was expressed in neurons and reactive astrocytes following TBI but not in quiescent astrocytes in normal brains. Furthermore, we detected that proliferating cell nuclear antigen (PCNA) had the co-localization with GFAP, and tropomyosin. In conclusion, this was the first description of tropomyosin expression in rat traumatic brain. Our date suggested that tropomyosin might be involved in the astrocytes proliferation following TBI.

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Acknowledgments

This study was supported by the National Natural Science Foundation of China (No. 81070992) and A Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD).

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Authors and Affiliations

  1. The Department of Neurology, Second Affiliated Hospital of Soochow University, Suzhou, China

    Xinmin Wu

  2. Department of Neurology, Affiliated Hospital of Nantong University, Nantong, 226001, Jiangsu, People’s Republic China

    Xinmin Wu, Hongran Fu, Feihui Zou, Wei Jin, Ting Xu, Peipei Gong, Yaohua Yan, Gang Cui, Kaifu Ke, Yilu Gao & Yongjin Pan

  3. The Department of Psychiatry, The Fourth People’s Hospital of Nantong, Nantong, 226001, Jiangsu, People’s Republic China

    Jian Xu

  4. The Department of Neurology, Second Affiliated Hospital of Soochow University, Suzhou, China

    Chunfeng Liu

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  1. Xinmin Wu
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Corresponding authors

Correspondence to Yilu Gao, Chunfeng Liu or Yongjin Pan.

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Xinmin Wu and Hongran Fu contributed equally to this work.

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Wu, X., Fu, H., Zou, F. et al. Increased expression of actin filament-stabilizing protein tropomyosin after rat traumatic brain injury. J Mol Hist 44, 37–45 (2013). https://doi.org/10.1007/s10735-012-9461-8

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  • DOI: https://doi.org/10.1007/s10735-012-9461-8

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