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Assessing the Usability of a Science Gateway for Medical Knowledge Bases with TRENCADIS

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Abstract

Biomedical applications are often built on top of knowledge bases that contain medical images and clinical reports. Currently, these bases are being used to improve diagnosis, research and teaching, but in many cases, the infrastructure required has a prohibitive cost for many medical centres. However, resources can be attached from existing e-Science infrastructures. Therefore, many efforts have been made to establish best practices that allow the use of such infrastructures. However, e-Science relies on open, distributed, collaborative environments, built on top of very specialized technologies, such as Grid and Cloud computing, which require reasonable technical skills for their usage. Therefore, science gateways have become essential tools that assist users in interacting with e-Science applications. This paper describes TRENCADIS, a technology that supports the creation and operation of virtual knowledge bases. To this end, it provides developers with components and APIs for building secure data services that can be annotated and queried through ontology templates, based on DICOM and DICOM-SR. This technology was used in this paper to build a gateway for assisting diagnosis and research in breast cancer. We also present here the results of a study conducted to evaluate the gateway, from the point of view of the usability perceived by a group of physicians and radiologists.

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References

  1. Afgan, E., Goecks, J., Baker, D., Coraor, N., Team The Galaxy, Nekrutenko, A., Taylor, J.: Galaxy—a gateway to tools in e-Science. In: Yang, X., Wang, L., Jie, W. (eds.) Guide to e-Science: Next Generation Scientific Research and Discovery, pp. 145–180. Springer (2011)

  2. Aisen, A.M., Broderick, L.S., Winer-Muram, H., Brodley, C.E., Kak, A.C., Pavlopoulou, C., Dy, J., Shyu, C.R., Marchiori, A.: Automated storage and retrieval of thin-section CT images to assist diagnosis: system description and preliminary assessment. Radiology 228(1), 265–270 (2003)

    Article  Google Scholar 

  3. Allcock, W.: GridFTP: protocol extensions to FTP for the Grid. Tech. rep., Argonne National Laboratory (2003). http://www.ggf.org/documents/GFD.20.pdf

  4. Andronico, G., Ardizzone, V., Barbera, R., Becker, B., Bruno, R., Calanducci, A., Carvalho, D., Ciuffo, L., Fargetta, M., Giorgio, E., Rocca, G., Masoni, A., Paganoni, M., Ruggieri, F., Scardaci, D.: e-Infrastructures for e-Science: a global view. J. Grid Computing 9(2), 155–184 (2011). doi:10.1007/s10723-011-9187-y

    Article  Google Scholar 

  5. Bastien, J.M.C.: Usability testing: a review of some methodological and technical aspects of the method. Int. J. Med. Inform. 79(4), e18–e23 (2010)

    Article  Google Scholar 

  6. Bastien, J.M.C., Scapin, D.L.: Ergonomic Criteria for the Evaluation of Human-Computer Interfaces (1993)

  7. Blanquer, I., Hernández, V., Segrelles, D., Torres, E.: Enhancing privacy and authorization control scalability in the Grid through ontologies. IEEE Trans. Inf. Technol. Biomed. 13(1), 16–24 (2009). doi:10.1109/TITB.2008.2003369

    Article  Google Scholar 

  8. Blanquer, I., Hernández, V., Salavert, J., Segrelles, D.: Integrating TRENCADIS components in gLite to share DICOM medical images and structured reports. Stud. Health Technol. Inform. 159, 64–75 (2010)

    Google Scholar 

  9. Blanquer Espert, I., Hernández García, V., Meseguer Anastásio, F.J., Segrelles Quilis, J.D.: Content-based organisation of virtual repositories of DICOM objects. Future Gener. Comput. Syst. 25(6), 627–637 (2009). doi:10.1016/j.future.2008.12.004

    Article  Google Scholar 

  10. Buyya, R., Yeo, C.S., Venugopal, S., Broberg, J., Brandic, I.: Cloud computing and emerging IT platforms: vision, hype, and reality for delivering computing as the 5th utility. Future Gener. Comput. Syst. 25(6), 599–616 (2009). doi:10.1016/j.future.2008.12.001

    Article  Google Scholar 

  11. Clunie, D.A.: DICOM Structured Reporting. PixelMed, Bangor (2000)

    Google Scholar 

  12. Cockburn, A.: Writing Effective Use Cases. Addison-Wesley Professional (2000)

  13. Costa, C., Ferreira, C., Bastião, L., Ribeiro, L., Silva, A., Oliveira, J.: Dicoogle—an open source peer-to-peer PACS. J. Digit. Imaging 24(5), 848–856 (2011). doi:10.1007/s10278-010-9347-9

    Article  Google Scholar 

  14. Cunsolo, V.D., Distefano, S., Puliafito, A., Scarpa, M.L.: GS3: a Grid storage system with security features. J. Grid Computing 8(3), 391–418 (2010). doi:10.1007/s10723-010-9157-9

    Article  Google Scholar 

  15. Dumas, J.S., Redish, J.: A Practical Guide to Usability Testing. Intellect Ltd (1999)

  16. European Commission: A digital agenda for Europe. Communication 5(245 final/2), 42 (2010)

    Google Scholar 

  17. European Commission: Riding the wave—how Europe can gain from the rising tide of scientific data. Final report of the High Level Expert Group on Scientific Data. Tech. Rep. October, European Commission (2010)

  18. European Commission: Safeguarding privacy in a connected world a European data protection framework for the 21st century. Tech. rep., European Commission, Brussels, Belgium (2012)

  19. Freund, J., Comaniciu, D., Ioannis, Y., Liu, P., McClatchey, R., Morley-Fletcher, E., Pennec, X., Pongiglione, G., Xiang, Zhou: Health-e-child: an integrated biomedical platform for Grid-based paediatric applications. Stud. Health Technol. Inform. 120, 259–270 (2006)

    Google Scholar 

  20. Fuster-Garcia, E., Navarro, C., Vicente, J., Tortajada, S., García-Gómez, J.M., Sáez, C., Calvar, J., Griffiths, J., Julià-Sapé, M., Howe, F.A., Pujol, J., Peet, A.C., Heerschap, A., Moreno-Torres, A., Martínez-Bisbal, M.C., Martínez-Granados, B., Wesseling, P., Semmler, W., Capellades, J., Majós, C., Alberich-Bayarri, A., Capdevila, A., Monleón, D., Martí-Bonmatí, L., Arús, C., Celda, B., Robles, M.: Compatibility between 3T 1H SV-MRS data and automatic brain tumour diagnosis support systems based on databases of 1.5T 1H SV-MRS spectra. Magma (N.Y. N.Y.) 24(1), 35–42 (2011). doi:10.1007/s10334-010-0241-8

    Google Scholar 

  21. Geer, L.Y., Marchler-Bauer, A., Geer, R.C., Han, L., He, J., He, S., Liu, C., Shi, W., Bryant, S.H.: The NCBI BioSystems database. Nucleic Acids Res. 38(Database issue), D492–6 (2010). doi:10.1093/nar/gkp858

    Google Scholar 

  22. Giger, M.L.: Intelligent CAD workstation for breast imaging using similarity to known lesions and multiple visual prompt aids. Proc. SPIE 4684, 768–773 (2002). doi:10.1117/12.467222

    Article  Google Scholar 

  23. Grethe, J.S., Baru, C., Gupta, A., James, M., Ludaescher, B., Martone, M.E., Papadopoulos, P.M., Peltier, S.T., Rajasekar, A., Santini, S., Zaslavsky, I.N., Ellisman, M.H.: Biomedical informatics research network: building a national collaboratory to hasten the derivation of new understanding and treatment of disease. Stud. Health Technol. Inform. 112, 100–109 (2005)

    Google Scholar 

  24. Hornbak, K.: Current practice in measuring usability: challenges to usability studies and research. Int. J. Human-Comput. Stud. 64(2), 79–102 (2006). doi:10.1016/j.ijhcs.2005.06.002

    Article  Google Scholar 

  25. ISO—International Organization for Standardization: Ergonomic requirements for office work with visual display terminals (VDTs)—part 11: guidance on usability (1998)

  26. ISO—International Organization for Standardization: Software engineering—product quality—part 4: quality in use metrics (2004)

  27. Jaspers, M.W.M.: A comparison of usability methods for testing interactive health technologies: methodological aspects and empirical evidence. Int. J. Med. Inform. 78(5), 340–353 (2009)

    Article  Google Scholar 

  28. Kranzlmüller, D., Lucas, J.M., Öster, P.: The European Grid Initiative (EGI). In: Davoli, F., Pugliese, R., Meyer, N., Zappatore, S. (eds.) Remote Instrumentation and Virtual Laboratories, pp. 61–66. Springer (2010). doi:10.1007/978-1-4419-5597-5_6

  29. Langlotz, C.P.: RadLex: a new method for indexing online educational materials. Radiographics 26(6), 1595–1597. doi:10.1148/rg.266065168

  30. Lee, K.P., Hu, J.: XML schema representation of DICOM structured reporting. J. Am. Med. Inform. Assoc. 10(2), 213–223 (2003)

    Article  MathSciNet  Google Scholar 

  31. Lenert, L., Sundwall, D.N.: Public health surveillance and meaningful use regulations: a crisis of opportunity. Am. J. Publ. Health 102(3), e1–e7 (2012). doi:10.2105/AJPH.2011.300542

    Article  Google Scholar 

  32. Lewis, J.: IBM computer usability satisfaction questionnaires: psychometric evaluation and instructions for use. Int. J. Hum.-Comput. Interact. 7(1), 57–78 (1995). doi:10.1080/10447319509526110

    Article  Google Scholar 

  33. Lewis, J.R.: Psychometric evaluation of the PSSUQ using data from five years of usability studies. Int. J. Hum.-Comput. Interact. 14(3–4), 463–488 (2002). doi:10.1080/10447318.2002.9669130

    Google Scholar 

  34. Lindland, O.I., Sindre, G., Solvberg, A.: Understanding quality in conceptual modeling. IEEE Softw. 11(2), 42–49 (1994). doi:10.1109/52.268955

    Article  Google Scholar 

  35. Llorente, I.M., Moreno-Vozmediano, R., Montero, R.S.: Cloud computing for on-demand resource provisioning. In: Gentzsch, W., Grandinetti, L., Joubert, G. (eds.) High Speed and Large Scale Scientific Computing, pp. 177–191. IOS Press, Amsterdam (2009). doi:10.3233/978-1-60750-073-5-177

  36. Napel, S.A., Beaulieu, C.F., Rodriguez, C., Cui, J., Xu, J., Gupta, A., Korenblum, D., Greenspan, H., Ma, Y., Rubin, D.L.: Automated retrieval of CT images of liver lesions on the basis of image similarity: method and preliminary results. Radiology 256(1), 243–252 (2010)

    Article  Google Scholar 

  37. Nielsen, J.: Usability Engineering, vol. 44. Morgan Kaufmann (1993)

  38. OGF—Open Grid Forum: The Storage Resource Manager Interface Specification Version 2.2. Tech. rep. (2008). http://www.ogf.org/documents/GFD.129.pdf

  39. OGF—Open Grid Forum: A simple API for Grid applications (SAGA). Tech. rep. (2011). http://www.ogf.org/documents/GFD.90.pdf

  40. OGF—Open Grid Forum: Data Format Description Language (DFDL) v1.0 Specification. Tech. rep. (2011). http://www.ogf.org/documents/GFD.174.pdf

  41. OGF—Open Grid Forum: Distributed Resource Management Application API Version 2 (DRMAA). Tech. rep. (2012). http://www.ogf.org/documents/GFD.194.pdf

  42. Pereira, J.A., Quach, S., Hamid, J.S., Heidebrecht, C.L., Quan, S.D., Nassif, J., Diniz, A.J., Exan, R.V., Malawski, J., Gentry, A., Finkelstein, M., Guay, M., Buckeridge, D.L., Bettinger, J.A., Kalailieff, D., Kwong, J.C.: Exploring the feasibility of integrating barcode scanning technology into vaccine inventory recording in seasonal influenza vaccination clinics. Vaccine 30(4), 794–802 (2012). doi:10.1016/j.vaccine.2011.11.043

    Article  Google Scholar 

  43. Ramos-Pollán, R., Guevara-López, M.A., Suárez-Ortega, C., Díaz-Herrero, G., Franco-Valiente, J.M., Rubio-Del-Solar, M., González-de Posada, N., Vaz, M.A.P., Loureiro, J., Ramos, I.: Discovering mammography-based machine learning classifiers for breast cancer diagnosis. J. Med. Syst. 36(4), 2259–2269 (2012). doi:10.1007/s10916-011-9693-2

    Article  Google Scholar 

  44. Redolfi, A., McClatchey, R., Anjum, A., Zijdenbos, A., Manset, D., Barkhof, F., Spenger, C., Legré, Y., Wahlund, L.O., Pietro, C.B.d.S., B Frisoni, G.: Grid infrastructures for computational neuroscience: the neuGRID example. Future Neurol. 4(6), 703–722 (2009). doi:10.2217/fnl.09.53

    Article  Google Scholar 

  45. Rimal, B.P., Jukan, A., Katsaros, D., Goeleven, Y.: Architectural requirements for cloud computing cystems: an enterprise cloud approach. J. Grid Computing 9(1), 3–26 (2010). doi:10.1007/s10723-010-9171-y

    Article  Google Scholar 

  46. Rings, T., Caryer, G., Gallop, J., Grabowski, J., Kovacikova, T., Schulz, S., Stokes-Rees, I.: Grid and cloud computing: opportunities for integration with the next generation network. J. Grid Computing 7(3), 375–393 (2009). doi:10.1007/s10723-009-9132-5

    Article  Google Scholar 

  47. Rodero-Merino, L., Vaquero, L.M., Gil, V., Galán, F., Fontán, J., Montero, R.S., Llorente, I.M.: From infrastructure delivery to service management in clouds. Future Gener. Comput. Syst. 26(8), 1226–1240 (2010). doi:10.1016/j.future.2010.02.013

    Article  Google Scholar 

  48. Rosenthal, A., Mork, P., Li, M.H., Stanford, J., Koester, D., Reynolds, P.: Cloud computing: a new business paradigm for biomedical information sharing. Journal of Biomedical Informatics 43(2), 342–353 (2010)

    Article  Google Scholar 

  49. Ruch, P., Gobeill, J., Lovis, C., Geissbühler, A.: Automatic medical encoding with SNOMED categories. BMC Med. Inform. Decis. Mak. 8(Suppl 1), S6 (2008). doi:10.1186/1472-6947-8-S1-S6

    Article  Google Scholar 

  50. Salavert Torres, J., Maestre Urbano, C.V., Segrelles Quilis, J.D., Blanquer Espert, I., Garcia, H.V., Martí Bonmatí, L.: Grid prototype to support cancer of breast diagnostics in clinic practice. In: IBERGRID’2010—4th Iberian Grid Infrastructure Conference. Netbiblo, Braga, pp. 285–294 (2010)

    Google Scholar 

  51. Saleem, J., Haggstrom, D., Militello, L., Flanagan, M., Kiess, C., Arbuckle, N., Doebbeling, B.: Redesign of a computerized clinical reminder for colorectal cancer screening: a human-computer interaction evaluation. BMC Med. Inform. Decis. Mak. 11(1), 74 (2011). doi:10.1186/1472-6947-11-74

    Article  Google Scholar 

  52. Schwiegelshohn, U., Badia, R.M., Bubak, M., Danelutto, M., Dustdar, S., Gagliardi, F., Geiger, A., Hluchy, L., Kranzlmüller, D., Laure, E.: Perspectives on Grid computing. Future Gener. Comput. Syst. 26(8), 1104–1115 (2010). doi:10.1016/j.future.2010.05.010

    Article  Google Scholar 

  53. Segrelles, D., Blanquer, I., Salavert, J., Hernandez, V., Franco, J.M., Diaz, G., Ramos, R., Medina, R., Marti, L., Guevara, M.A., Gonzalez, N., Loureiro, J., Ramos, I.: Exchanging data for breast cancer diagnosis on heterogeneous Grid platforms. Comput. Inform. 31(1), 3–15 (2012)

    Google Scholar 

  54. Serco Usability Services: Performance Measurement Handbook, version 3 edn. Middlesex, UK (1995)

  55. Shapiro, S.S., Wilk, M.B.: An analysis of variance test for normality (complete samples). Biometrika 52(3–4), 591–611 (1965). doi:10.1093/biomet/52.3-4.591

    MathSciNet  MATH  Google Scholar 

  56. Silva, L., Costa, C., Oliveira, J.: A PACS archive architecture supported on cloud services. Int. J. Comput. Assist. Radiol. Surg. 7(3), 349–358 (2012). doi:10.1007/s11548-011-0625-x

    Article  Google Scholar 

  57. Teng, C.C., Mitchell, J., Walker, C., Swan, A., Davila, C., Howard, D., Needham, T.: A medical image archive solution in the cloud. In: 2010 IEEE International Conference on Software Engineering and Service Sciences (ICSESS), pp. 431–434 (2010). doi:10.1109/ICSESS.2010.5552343

  58. Van Rijsbergen, C.J.: Information retrieval. In: The Kluwer International Series on Information Retrieval, vol. 30. Butterworths (1979). doi:10.1016/0020-0271(68)90016-8

  59. Weiss, D.L., Langlotz, C.P.: Structured reporting: patient care enhancement or productivity nightmare? Radiology 249(3), 739–747 (2008). doi:10.1148/radiol.2493080988

    Article  Google Scholar 

  60. Wess, M.L., Saleem, J.J., Tsevat, J., Luckhaupt, S.E., Johnston, J.A., Wise, R.E., Kopke, J.E., Eckman, M.H.: Usability of an atrial fibrillation anticoagulation decision-support tool. J. Prim. Care Community Health 2(2), 100–106 (2011). doi:10.1177/2150131910387608

    Article  Google Scholar 

  61. Zentner, L.K., Clark, S.M., Smith, P.M., Shivarajapura, S., Farnsworth, V., Madhavan, K.P.C., Klimeck, G.: Practical considerations in cloud utilization for the science gateway nanoHUB.org. In: 2011 Fourth IEEE International Conference on Utility and Cloud Computing (UCC), pp. 287–292 (2011). doi:10.1109/UCC.2011.46

  62. Zhao, L., Lee, K.P., Hu, J.: Generating XML schemas for DICOM structured reporting templates. J. Am. Med. Inform. Assoc. 12(1), 72–83 (2005)

    Article  Google Scholar 

  63. Zheng, B., Mello-Thoms, C., Wang, X.H., Abrams, G.S., Sumkin, J.H., Chough, D.M., Ganott, M.A., Lu, A., Gur, D.: Interactive computer-aided diagnosis of breast masses: computerized selection of visually similar image sets from a reference library. Acad. Radiol. 14(8), 917–927 (2007)

    Article  Google Scholar 

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Maestre, C., Segrelles Quilis, J.D., Torres, E. et al. Assessing the Usability of a Science Gateway for Medical Knowledge Bases with TRENCADIS. J Grid Computing 10, 665–688 (2012). https://doi.org/10.1007/s10723-012-9243-2

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