Article

Genetica

, Volume 136, Issue 1, pp 97-107

Gene mapping in the wild with SNPs: guidelines and future directions

  • Jon SlateAffiliated withDepartment of Animal & Plant Sciences, University of Sheffield Email author 
  • , Jake GrattenAffiliated withDepartment of Animal & Plant Sciences, University of Sheffield
  • , Dario BeraldiAffiliated withInstitute of Evolutionary Biology, University of Edinburgh
  • , Jessica StapleyAffiliated withDepartment of Animal & Plant Sciences, University of Sheffield
  • , Matt HaleAffiliated withDepartment of Animal & Plant Sciences, University of SheffieldDepartment of Forestry and Natural Resources, Purdue University
  • , Josephine M. PembertonAffiliated withInstitute of Evolutionary Biology, University of Edinburgh

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Abstract

One of the biggest challenges facing evolutionary biologists is to identify and understand loci that explain fitness variation in natural populations. This review describes how genetic (linkage) mapping with single nucleotide polymorphism (SNP) markers can lead to great progress in this area. Strategies for SNP discovery and SNP genotyping are described and an overview of how to model SNP genotype information in mapping studies is presented. Finally, the opportunity afforded by new generation sequencing and typing technologies to map fitness genes by genome-wide association studies is discussed.

Keywords

Gene discovery QTL Linkage Mapping SNP Wild population