Genetica

, Volume 136, Issue 1, pp 97–107

Gene mapping in the wild with SNPs: guidelines and future directions

Authors

    • Department of Animal & Plant SciencesUniversity of Sheffield
  • Jake Gratten
    • Department of Animal & Plant SciencesUniversity of Sheffield
  • Dario Beraldi
    • Institute of Evolutionary BiologyUniversity of Edinburgh
  • Jessica Stapley
    • Department of Animal & Plant SciencesUniversity of Sheffield
  • Matt Hale
    • Department of Animal & Plant SciencesUniversity of Sheffield
    • Department of Forestry and Natural ResourcesPurdue University
  • Josephine M. Pemberton
    • Institute of Evolutionary BiologyUniversity of Edinburgh
Article

DOI: 10.1007/s10709-008-9317-z

Cite this article as:
Slate, J., Gratten, J., Beraldi, D. et al. Genetica (2009) 136: 97. doi:10.1007/s10709-008-9317-z

Abstract

One of the biggest challenges facing evolutionary biologists is to identify and understand loci that explain fitness variation in natural populations. This review describes how genetic (linkage) mapping with single nucleotide polymorphism (SNP) markers can lead to great progress in this area. Strategies for SNP discovery and SNP genotyping are described and an overview of how to model SNP genotype information in mapping studies is presented. Finally, the opportunity afforded by new generation sequencing and typing technologies to map fitness genes by genome-wide association studies is discussed.

Keywords

Gene discovery QTL Linkage Mapping SNP Wild population

Copyright information

© Springer Science+Business Media B.V. 2008