Genetica

, Volume 135, Issue 3, pp 415–418

The recent origin of the Sdic gene cluster in the melanogaster subgroup

Article

DOI: 10.1007/s10709-008-9288-0

Cite this article as:
Ponce, R. Genetica (2009) 135: 415. doi:10.1007/s10709-008-9288-0

Abstract

Gene families are composed of closely related genes and are an important part of eukaryotic genomes. In the proximal region of the X chromosome of Drosophila melanogaster there is a cluster of four tandem Sdic genes, located between the gene Cdic and the gene AnnX. Sdic is a chimeric gene that encodes a novel protein with sperm-specific expression. It had been hypothesized that the Sdic gene cluster was formed after the split of D. melanogaster and D. simulans. To study the evolution of this cluster, the sequence of this region was studied in several Drosophilidae species. In all species analyzed, Sdic genes are absent and AnnX and Cdic are adjacent to each other. The results allowed the inference of the ancestral situation and the reconstruction of the evolution of the cluster, and confirm that the Sdic cluster was indeed formed in the lineage that gave rise to D. melanogaster, being one of the youngest gene clusters known.

Keywords

Gene duplicationNovel geneGene familyGene clusterSdicX chromosome

Abbreviations

AnnX

Gene encoding annexin X

Cdic

Gene encoding cytoplasmic dynein intermediate chain

Sdic

Gene encoding sperm-specific dynein intermediate chain

bp

Base pair(s)

A

Adenosine

C

Cytidine

G

Guanosine

T

Thymidine

LTR

Long terminal repeat

UTR

Untranslated region

Supplementary material

10709_2008_9288_MOESM1_ESM.doc (52 kb)
MOESM1 Table 1 Complete alignment of the region between genes AnnX and Cdic in the species D. simulans, D. mauritiana, D. yakuba, D. teissieri and D. erecta (DOC 52 kb)
10709_2008_9288_MOESM2_ESM.doc (70 kb)
MOESM2 Table 2 Complete alignment of the region between genes AnnX and Cdic in the species D. simulans, D. mauritiana, D. yakuba, D. teissieri and D. erecta and intergenic regions of the Sdic cluster in D. melanogaster (DOC 70 kb)
10709_2008_9288_MOESM3_ESM.doc (53 kb)
MOESM3 Table 3 Sequence alignments of AnnX gene in D. melanogaster, D. simulans, D. mauritiana, D. yakuba, D. teissieri and D. erecta (DOC 53 kb)
10709_2008_9288_MOESM4_ESM.doc (46 kb)
MOESM4 Table 4 Sequence alignments of Cdic gene in D. melanogaster, D. simulans, D. mauritiana, D. yakuba, D. teissieri and D. erecta (DOC 45 kb)

Copyright information

© Springer Science+Business Media B.V. 2008

Authors and Affiliations

  1. 1.Centro de Biologia Ambiental, Departamento de Biologia VegetalFaculdade de Ciências da Universidade de LisboaLisboaPortugal
  2. 2.Department of Organismic and Evolutionary BiologyHarvard UniversityCambridgeUSA