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Effects of lipoic acid on growth and biochemical responses of common carp fed with carbohydrate diets

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Abstract

Lipoic acid (LA) is an antioxidant that also favors glucose uptake in mammals. Until now, there are no studies evaluating the potential effect of this molecule on glycemic control in fish. It was evaluated LA effects on glucose uptake in common carp Cyprinus carpio fed with carbohydrate diets from two carbohydrate sources: glucose (GLU) and starch (STA), and supplemented or not with LA, being the diets: +GLU/−LA (GLU); +GLU/+LA (GLU + LA); +STA/−LA (STA); and +STA/+LA (STA + LA). Carp juveniles (6.5 ± 0.1 g) were fed with each diet ad libitum 4 times a day, during 68 days. Muscle glycogen concentration was higher (p < 0.05) in GLU and GLU + LA than in STA and STA + LA groups. On fish fed with starch, muscle cholesterol and triglyceride concentrations were higher (p < 0.05) in fish fed diets supplemented with LA. Muscle protein levels were higher in fish fed with LA, independent of the diet carbohydrate source. Lipid peroxidation was significantly reduced (p < 0.05) in fish muscle on fish fed the STA + LA diets when compared with the STA diet. Our findings indicate that LA modulates lipid, proteins and carbohydrate metabolism together with the well-known antioxidant effect. Also, LA showed to enhance starch utilization taking into account muscle cholesterol and triglyceride levels.

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Acknowledgments

The authors would like to thank Dr. Ricardo Roubax Robaldo of Federal University of Pelotas (UFPel). The authors also thank Dr. Luis Alberto Romano, M.Sc. Paola Milena, MSc. Juan Zamora-Sillero, Dr. Eduardo Martins Silva and oxidative stress and toxicology research group (EAOx) for sampling and analysis contributions. J. M. Monserrat; E. Pimentel and Marcelo B. Tesser are research fellows from Brazilian agency CNPq (process numbers PQ 307880/2013-3, DT 311605/2009-5 and PQ 308680/2014-6, respectively). R. A. Santos received support from the Brazilian Council of Research, CNPq.

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Authors and Affiliations

  1. Instituto de Ciências Biológicas (ICB), Programa de Pós Graduação em Ciências Fisiológicas - Fisiologia Animal Comparada, Universidade Federal do Rio Grande – FURG, Campus Carreiros, Av Itália km 8 s/n, PO Box 474, Rio Grande, RS, 96200-970, Brazil

    R. A. Santos & J. M. Monserrat

  2. Escola de Química e Alimentos (EQA), FURG, Rio Grande, RS, Brazil

    S. Caldas & E. G. Primel

  3. Instituto de Oceanografia (IO), FURG, Rio Grande, RS, Brazil

    M. B. Tesser

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  1. R. A. Santos
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  2. S. Caldas
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  3. E. G. Primel
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  4. M. B. Tesser
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  5. J. M. Monserrat
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Correspondence to J. M. Monserrat.

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Santos, R.A., Caldas, S., Primel, E.G. et al. Effects of lipoic acid on growth and biochemical responses of common carp fed with carbohydrate diets. Fish Physiol Biochem 42, 1699–1707 (2016). https://doi.org/10.1007/s10695-016-0250-2

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  • DOI: https://doi.org/10.1007/s10695-016-0250-2

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