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Management of renal tumors in Von Hippel-Lindau disease by percutaneous CT fluoroscopic guided radiofrequency ablation: preliminary results

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Abstract

We evaluated the feasibility and safety of percutaneous radiofrequency (RF) ablation of renal cell carcinomas (RCCs) in patients with Von Hippel-Lindau (VHL) disease. A total of 12 RCCs were treated by RF ablation in 7 patients with VHL disease. RF electrodes were placed under CT fluoroscopic guidance with conscious sedation. Technical success, technical effectiveness (disappearance of tumor enhancement), local tumor progression, complications and change in the estimated glomerular filtration rate (eGFR) were evaluated. A total of 9 sessions were undertaken. All procedures were performed with a planned protocol with a technical success rate of 100%. Tumor enhancement disappeared in all 12 tumors indicating a technical effectiveness rate of 100%. Local tumor progression was not found in any patient during the mean follow-up of 22 ± 11 months (range 12–46 months). There were no complications related to the RF procedures. The mean eGFR decreased from 65.3 ± 10.9 ml/min (range 48.5–77.5 ml/min) to 60.3 ± 11.3 ml/min (range, 45.8–73.4 ml/min, P < 0.03). The mean percentage decrease in eGFR after the last ablation was 7.6% (range 0–21.6%). Renal RF ablation is a safe and effective treatment for renal tumours that may allow patients with VHL disease to avoid major surgical interventions.

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Abbreviations

RCCs:

Renal cell carcinomas

CNS:

Central nervous system

RF:

Renal radiofrequency

CT:

Computed tomography

eGFR:

Estimated glomerular filtration rate

VHL:

Von Hippel-Lindau

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Authors and Affiliations

  1. Department of Urologic Surgery and Andrology, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan

    Yoichi Iwamoto, Hideki Kanda, Norihito Soga, Kiminobu Arima & Yoshiki Sugimura

  2. Department of Radiology, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan

    Koichiro Yamakado & Kan Takeda

Authors
  1. Yoichi Iwamoto
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  2. Hideki Kanda
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  3. Koichiro Yamakado
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  4. Norihito Soga
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  5. Kiminobu Arima
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  6. Kan Takeda
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  7. Yoshiki Sugimura
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Correspondence to Yoichi Iwamoto.

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Iwamoto, Y., Kanda, H., Yamakado, K. et al. Management of renal tumors in Von Hippel-Lindau disease by percutaneous CT fluoroscopic guided radiofrequency ablation: preliminary results. Familial Cancer 10, 529–534 (2011). https://doi.org/10.1007/s10689-011-9440-3

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