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Pheochromocytoma-associated syndromes: genes, proteins and functions of RET, VHL and SDHx

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Abstract

Pheochromocytoma are tumors derived from chromaffin cells that secrete catecholamines. These catecholamines may lead to increased blood pressure and even death. Historically, pheochromocytoma have been described as 10 tumor, i.e. about 10 were believed to be malignant, 10 were found to be extra-adrenal, and 10 were meant to be bilateral. Also, about 10 were considered to be hereditary. In these instances, they were most often part of either the multiple endocrine neoplasia type 2 (MEN 2) syndrome or the von Hippel–Lindau (VHL) disease. The genes (RET and VHL) involved have been known for several years and their function is the subject of ongoing investigation. Very recently, several genes (SDHD, SDHB, and SDHC) that belong to the mitochondrial complex II have been identified to be involved in the so-called pheochromocytoma–paraganglioma syndrome. Only SDHD and SDHB have so far been implicated in the pathogenesis of pheochromocytoma.

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References

  1. LM Mulligan JB Kwok CS. Healey et al. (1993) ArticleTitlemutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A Nature 363 IssueID6428 458–60 Occurrence Handle10.1038/363458a0 Occurrence Handle1:CAS:528:DyaK3sXksVKms7s%3D Occurrence Handle8099202

    Article  CAS  PubMed  Google Scholar 

  2. RM Hofstra RM Landsvater I. Ceccherini et al. (1994) ArticleTitleA mutation in the RET proto-oncogene associated with multiple endocrine neoplasia type 2B and sporadic medullary thyroid carcinoma [see comments] Nature 367 IssueID6461 375–6 Occurrence Handle10.1038/367375a0 Occurrence Handle1:CAS:528:DyaK2cXhs1Shu78%3D Occurrence Handle7906866

    Article  CAS  PubMed  Google Scholar 

  3. O Gimm DJ Marsh SD. Andrew et al. (1997) ArticleTitledinucleotide mutation in codon 883 of the RET proto-oncogene in multiple endocrine neoplasia type 2B without codon 918 mutation J Clin Endocrinol Metab 82 IssueID11 3902–4 Occurrence Handle10.1210/jc.82.11.3902 Occurrence Handle1:CAS:528:DyaK2sXnt1Kgtrs%3D Occurrence Handle9360560

    Article  CAS  PubMed  Google Scholar 

  4. L Kasprzak S Nolet L. Gaboury et al. (2001) ArticleTitlemedullary thyroid carcinoma and prominent corneal nerves associated with the germline V804M and V778I mutations on the same allele of RET J Med Genet 38 IssueID11 784–7 Occurrence Handle10.1136/jmg.38.11.784 Occurrence Handle1:CAS:528:DC%2BD3MXptVKqsLY%3D Occurrence Handle11732489

    Article  CAS  PubMed  Google Scholar 

  5. FH Menko RB Luijt Particlevan der IA. Valk Particlede et al. (2002) ArticleTitleMEN type 2B associated with two germline RET mutations on the same allele not involving codon 918 J Clin Endocrinol Metab 87 IssueID1 393–7 Occurrence Handle10.1210/jc.87.1.393 Occurrence Handle1:CAS:528:DC%2BD38XntVyrtw%3D%3D Occurrence Handle11788682

    Article  CAS  PubMed  Google Scholar 

  6. M Takahashi J Ritz GM. Cooper (1985) ArticleTitleActivation of a novel human transforming gene, ret, by DNA rearrangement Cell 42 IssueID2 581–8 Occurrence Handle10.1016/0092-8674(85)90115-1 Occurrence Handle1:CAS:528:DyaL2MXlsFGhs74%3D Occurrence Handle2992805

    Article  CAS  PubMed  Google Scholar 

  7. JF Powers P Tsokas AS. Tischler (1998) ArticleTitleThe ret-activating ligand GDNF is differentiative and not mitogenic for normal and neoplastic human chromaffin cells in vitro Endocrinol Pathol 9 IssueID1 325–31 Occurrence Handle1:CAS:528:DyaK1MXhvVShsrY%3D

    CAS  Google Scholar 

  8. CL Smith-Hicks KC Sizer JF. Powers et al. (2000) ArticleTitlehyperplasia, pheochromocytoma and sympathoadrenal malformation in a mouse model of multiple endocrine neoplasia type 2B EMBO J 19 IssueID4 612–22 Occurrence Handle10.1093/emboj/19.4.612 Occurrence Handle1:CAS:528:DC%2BD3cXhsFKms74%3D Occurrence Handle10675330

    Article  CAS  PubMed  Google Scholar 

  9. FM Michiels S Chappuis B. Caillou et al. (1997) ArticleTitleof medullary thyroid carcinoma in transgenic mice expressing the RET protooncogene altered by a multiple endocrine neoplasia type 2A mutation Proc Natl Acad Sci USA 94 IssueID7 3330–5 Occurrence Handle10.1073/pnas.94.7.3330 Occurrence Handle1:CAS:528:DyaK2sXisVKnsr4%3D Occurrence Handle9096393

    Article  CAS  PubMed  Google Scholar 

  10. K Kawai T Iwashita H. Murakami et al. (2000) ArticleTitlecarcinogenesis in transgenic mice expressing the RET proto-oncogene with a multiple endocrine neoplasia type 2A mutation Cancer Res 60 IssueID18 5254–60 Occurrence Handle1:CAS:528:DC%2BD3cXntVamu7o%3D Occurrence Handle11016655

    CAS  PubMed  Google Scholar 

  11. SM Myers C Eng BA Ponder LM. Mulligan (1995) ArticleTitleCharacterization of RET proto-oncogene 3′ splicing variants and polyadenylation sites: A novel C-terminus for RET Oncogene 11 IssueID10 2039–45 Occurrence Handle1:CAS:528:DyaK2MXpslaktLY%3D Occurrence Handle7478523

    CAS  PubMed  Google Scholar 

  12. H Le Hir N Charlet-Berguerand V Franciscis Particlede C. Thermes (2002) ArticleTitle5′-End RET splicing: Absence of variants in normal tissues and intron retention in pheochromocytomas Oncology 63 IssueID1 84–91 Occurrence Handle10.1159/000065725 Occurrence Handle1:CAS:528:DC%2BD38XmtlGiu7o%3D Occurrence Handle12187076

    Article  CAS  PubMed  Google Scholar 

  13. R. Schneider (1992) ArticleTitleThe human protooncogene ret: a communicative cadherin? Trends Biochem Sci 17 IssueID11 468–9 Occurrence Handle10.1016/0968-0004(92)90490-Z Occurrence Handle1:CAS:528:DyaK3sXhtF2itbg%3D Occurrence Handle1455518

    Article  CAS  PubMed  Google Scholar 

  14. J Anders S Kjar CF. Ibanez (2001) ArticleTitleMolecular modeling of the extracellular domain of the RET receptor tyrosine kinase reveals multiple cadherin-like domains and a calcium-binding site J Biol Chem 276 IssueID38 35808–17 Occurrence Handle10.1074/jbc.M104968200 Occurrence Handle1:CAS:528:DC%2BD3MXntFahtrk%3D Occurrence Handle11445581

    Article  CAS  PubMed  Google Scholar 

  15. M Trupp E Arenas M. Fainzilber et al. (1996) ArticleTitlereceptor for GDNF encoded by the c-ret proto-oncogene [see comments] Nature 381 IssueID6585 785–8 Occurrence Handle10.1038/381785a0 Occurrence Handle1:CAS:528:DyaK28XjvVKnsr4%3D Occurrence Handle8657281

    Article  CAS  PubMed  Google Scholar 

  16. PT Kotzbauer PA Lampe RO. Heuckeroth et al. (1996) ArticleTitleNeurturin, a relative of glial-cell-line-derived neurotrophic factor Nature 384 IssueID6608 467–70 Occurrence Handle10.1038/384467a0 Occurrence Handle1:CAS:528:DyaK28XnsFWqurY%3D Occurrence Handle8945474

    Article  CAS  PubMed  Google Scholar 

  17. J Milbrandt FJ Sauvage Particlede TJ. Fahrner et al. (1998) ArticleTitle).Persephin, a novel neurotrophic factor related to GDNF and neurturin Neuron 20 IssueID2 245–53 Occurrence Handle10.1016/S0896-6273(00)80453-5 Occurrence Handle1:CAS:528:DyaK1cXhtlGnsL8%3D Occurrence Handle9491986

    Article  CAS  PubMed  Google Scholar 

  18. RH Baloh MG Tansey PA. Lampe et al. (1998) ArticleTitlea novel member of the GDNF ligand family, supports peripheral and central neurons and signals through the GFRalpha3-RET receptor complex Neuron 21 IssueID6 1291–302 Occurrence Handle10.1016/S0896-6273(00)80649-2 Occurrence Handle1:CAS:528:DyaK1MXntV2nsA%3D%3D Occurrence Handle9883723

    Article  CAS  PubMed  Google Scholar 

  19. S Jing D Wen Y. Yu et al. (1996) ArticleTitleGDNF-induced activation of the ret protein tyrosine kinase is mediated by GDNFR-alpha, a novel receptor for GDNF Cell 85 IssueID7 1113–24 Occurrence Handle10.1016/S0092-8674(00)81311-2 Occurrence Handle1:CAS:528:DyaK28XjvF2iu7c%3D Occurrence Handle8674117

    Article  CAS  PubMed  Google Scholar 

  20. S Jing Y Yu M. Fang et al. (1997) ArticleTitleand GFRalpha-3 are two new receptors for ligands of the GDNF family J Biol Chem 272 IssueID52 33111–7 Occurrence Handle10.1074/jbc.272.52.33111 Occurrence Handle1:CAS:528:DyaK1cXpsFSn Occurrence Handle9407096

    Article  CAS  PubMed  Google Scholar 

  21. Y Enokido F Sauvage Particlede JA. Hongo et al. (1998) ArticleTitlealpha-4 and the tyrosine kinase Ret form a functional receptor complex for persephin [in process citation] Curr Biol 8 IssueID18 1019–22 Occurrence Handle10.1016/S0960-9822(07)00422-8 Occurrence Handle1:CAS:528:DyaK1cXmtVelsrs%3D Occurrence Handle9740802

    Article  CAS  PubMed  Google Scholar 

  22. A Schuchardt V D’Agati L. Larsson-Blomberg et al. (1994) ArticleTitlein the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret Nature 367 IssueID6461 380–3 Occurrence Handle10.1038/367380a0 Occurrence Handle1:CAS:528:DyaK2cXhvVOqtr0%3D Occurrence Handle8114940

    Article  CAS  PubMed  Google Scholar 

  23. MS Airaksinen A Titievsky M. Saarma (1999) ArticleTitleGDNF family neurotrophic factor signaling: four masters, one servant? Mol Cell Neurosci 13 IssueID5 313–25 Occurrence Handle10.1006/mcne.1999.0754 Occurrence Handle1:CAS:528:DyaK1MXjsVGjsb4%3D Occurrence Handle10356294

    Article  CAS  PubMed  Google Scholar 

  24. RH Baloh H Enomoto EM Johnson SuffixJr J. Milbrandt (2000) ArticleTitleThe GDNF family ligands and receptors – implications for neural development Curr Opin Neurobiol 10 IssueID1 103–10 Occurrence Handle10.1016/S0959-4388(99)00048-3 Occurrence Handle1:CAS:528:DC%2BD3cXhslKrsrs%3D Occurrence Handle10679429

    Article  CAS  PubMed  Google Scholar 

  25. G Romeo P Ronchetto Y. Luo et al. (1994) ArticleTitlemutations affecting the tyrosine kinase domain of the RET proto-oncogene in Hirschsprung’s disease Nature 367 IssueID6461 377–8 Occurrence Handle10.1038/367377a0 Occurrence Handle1:CAS:528:DyaK2cXhs1Smtrs%3D Occurrence Handle8114938

    Article  CAS  PubMed  Google Scholar 

  26. F Carlomagno G Salvatore AM. Cirafici et al. (1997) ArticleTitledifferent RET-activating capability of mutations of cysteine 620 or cysteine 634 correlates with the multiple endocrine neoplasia type 2 disease phenotype Cancer Res 57 IssueID3 391–5 Occurrence Handle1:CAS:528:DyaK2sXhtVGlur0%3D Occurrence Handle9012462

    CAS  PubMed  Google Scholar 

  27. T Iwashita M Kato H. Murakami et al. (1999) ArticleTitleand biochemical properties of Ret with kinase domain mutations identified in multiple endocrine neoplasia type 2B and familial medullary thyroid carcinoma Oncogene 18 IssueID26 3919–22 Occurrence Handle1:CAS:528:DyaK1MXks1Omt7s%3D Occurrence Handle10445857

    CAS  PubMed  Google Scholar 

  28. N Asai T Iwashita M Matsuyama M. Takahashi (1995) ArticleTitleMechanism of activation of the ret proto-oncogene by multiple endocrine neoplasia 2A mutations Mol Cell Biol 15 IssueID3 1613–9 Occurrence Handle1:CAS:528:DyaK2MXjsl2rtbo%3D Occurrence Handle7532281

    CAS  PubMed  Google Scholar 

  29. M Santoro F. Carlomagno et al. (1995) ArticleTitleActivation of RET as a dominant transforming gene by germline mutations of MEN2A and MEN2B Science 267 IssueID5196 381–3 Occurrence Handle1:CAS:528:DyaK2MXjt12nsbo%3D Occurrence Handle7824936

    CAS  PubMed  Google Scholar 

  30. S Chappuis-Flament A Pasini G. De Vita et al. (1998) ArticleTitleeffect on the RET receptor of MEN 2 mutations affecting specific extracytoplasmic cysteines Oncogene 17 IssueID22 2851–61 Occurrence Handle1:CAS:528:DyaK1MXisVWksQ%3D%3D Occurrence Handle9879991

    CAS  PubMed  Google Scholar 

  31. S Borrego ME Saez A. Ruiz et al. (1999) ArticleTitlepolymorphisms in the RET proto-oncogene are over-represented in patients with Hirschsprung disease and may represent loci modifying phenotypic expression [in process citation] J Med Genet 36 IssueID10 771–4 Occurrence Handle1:CAS:528:DyaK1MXntVWnsrs%3D Occurrence Handle10528857

    CAS  PubMed  Google Scholar 

  32. MJ Lorenzo GD Gish C. Houghton et al. (1997) ArticleTitlealternate splicing influences the interaction of activated RET with the SH2 and PTB domains of Shc, and the SH2 domain of Grb2 Oncogene 14 IssueID7 763–71 Occurrence Handle1:CAS:528:DyaK2sXhs1Gltb4%3D Occurrence Handle9047383

    CAS  PubMed  Google Scholar 

  33. MG Borrello G Pelicci E. Arighi et al. (1994) ArticleTitleThe oncogenic versions of the Ret and Trk tyrosine kinases bind Shc and Grb2 adaptor proteins Oncogene 9 IssueID6 1661–8 Occurrence Handle1:CAS:528:DyaK2cXkslKmurY%3D Occurrence Handle8183561

    CAS  PubMed  Google Scholar 

  34. A Pandey X Liu JE. Dixon et al. (1996) ArticleTitleassociation between the Ret receptor tyrosine kinase and the Src homology 2-containing adapter protein Grb7 J Biol Chem 271 IssueID18 10607–10 Occurrence Handle1:CAS:528:DyaK28XivVaqtrY%3D Occurrence Handle8631863

    CAS  PubMed  Google Scholar 

  35. C Segouffin-Cariou M. Billaud (2000) ArticleTitleTransforming ability of MEN2A-RET requires activation of the phosphatidylinositol 3-kinase/AKT signaling pathway J Biol Chem 275 IssueID5 3568–76 Occurrence Handle1:CAS:528:DC%2BD3cXhtVygtLw%3D Occurrence Handle10652352

    CAS  PubMed  Google Scholar 

  36. B Zbar T Kishida F. Chen et al. (1996) ArticleTitleGermline mutations in the Von Hippel–Lindau disease (VHL) gene in families from North America, Europe, and Japan Hum Mutat 8 IssueID4 348–57 Occurrence Handle10.1002/(SICI)1098-1004(1996)8:4<348::AID-HUMU8>3.0.CO;2-3 Occurrence Handle1:CAS:528:DyaK2sXisFKqtQ%3D%3D Occurrence Handle8956040

    Article  CAS  PubMed  Google Scholar 

  37. FM Richards SJ Payne B. Zbar et al. (1995) ArticleTitleMolecular analysis of de novo germline mutations in the von Hippel–Lindau disease gene Hum Mol Genet 4 IssueID11 2139–43 Occurrence Handle1:CAS:528:DyaK2MXpt1Oquro%3D Occurrence Handle8589692

    CAS  PubMed  Google Scholar 

  38. PA Crossey FM Richards K. Foster et al. (1994) ArticleTitleIdentification of intragenic mutations in the von Hippel–Lindau disease tumour suppressor gene and correlation with disease phenotype Hum Mol Genet 3 IssueID8 1303–8 Occurrence Handle1:CAS:528:DyaK2cXlslWqtrs%3D Occurrence Handle7987306

    CAS  PubMed  Google Scholar 

  39. F Latif K Tory J. Gnarra et al. (1993) ArticleTitleIdentification of the von Hippel–Lindau disease tumor suppressor gene Science 260 IssueID5112 1317–20 Occurrence Handle1:CAS:528:DyaK3sXks12htbc%3D Occurrence Handle8493574

    CAS  PubMed  Google Scholar 

  40. PA Crossey K Foster FM. Richards et al. (1994) ArticleTitleMolecular genetic investigations of the mechanism of tumourigenesis in von Hippel– Lindau disease: analysis of allele loss in VHL tumours Hum Genet 93 IssueID1 53–8 Occurrence Handle1:CAS:528:DyaK2cXksl2ktrg%3D Occurrence Handle8270255

    CAS  PubMed  Google Scholar 

  41. BU Bender M Gutsche S. Glasker et al. (2000) ArticleTitlegenetic alterations in von Hippel–Lindau syndrome-associated and sporadic pheochromocytomas J Clin Endocrinol Metab 85 IssueID12 4568–74 Occurrence Handle10.1210/jc.85.12.4568 Occurrence Handle1:CAS:528:DC%2BD3MXis1ClsQ%3D%3D Occurrence Handle11134110

    Article  CAS  PubMed  Google Scholar 

  42. JG Herman F Latif Y. Weng et al. (1994) ArticleTitleof the VHL tumor-suppressor gene by DNA methylation in renal carcinoma Proc Natl Acad Sci USA 91 IssueID21 9700–4 Occurrence Handle1:CAS:528:DyaK2cXmvFCgsLs%3D Occurrence Handle7937876

    CAS  PubMed  Google Scholar 

  43. AH Prowse AR Webster FM. Richards et al. (1997) ArticleTitleSomatic inactivation of the VHL gene in von Hippel–Lindau disease tumors Am J Hum Genet 60 IssueID4 765–71 Occurrence Handle1:CAS:528:DyaK2sXisFehtLY%3D Occurrence Handle9106522

    CAS  PubMed  Google Scholar 

  44. WG Kaelin SuffixJr. (2002) ArticleTitleMolecular basis of the VHL hereditary cancer syndrome Nat Rev Cancer 2 IssueID9 673–82 Occurrence Handle10.1038/nrc885 Occurrence Handle1:CAS:528:DC%2BD38Xmslamsrg%3D Occurrence Handle12209156

    Article  CAS  PubMed  Google Scholar 

  45. DR Duan A Pause WH. Burgess et al. (1995) ArticleTitleInhibition of transcription elongation by the VHL tumor suppressor protein Science 269 IssueID5229 1402–6 Occurrence Handle1:CAS:528:DyaK2MXnvFClurg%3D Occurrence Handle7660122

    CAS  PubMed  Google Scholar 

  46. A Pause S Lee RA. Worrell et al. (1997) ArticleTitleThe von Hippel–Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins Proc Natl Acad Sci USA 94 IssueID6 2156–61 Occurrence Handle1:CAS:528:DyaK2sXhvF2lt7o%3D Occurrence Handle9122164

    CAS  PubMed  Google Scholar 

  47. K Kondo J Klco E. Nakamura et al. (2002) ArticleTitleInhibition of HIF is necessary for tumor suppression by the von Hippel–Lindau protein Cancer Cell 1 IssueID3 237–46 Occurrence Handle1:CAS:528:DC%2BD38XjsFGltrY%3D Occurrence Handle12086860

    CAS  PubMed  Google Scholar 

  48. JK Maranchie JR Vasselli J. Riss et al. (2002) ArticleTitleThe contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma Cancer Cell 1 IssueID3 247–55 Occurrence Handle1:CAS:528:DC%2BD38XjsFGltrc%3D Occurrence Handle12086861

    CAS  PubMed  Google Scholar 

  49. T Bourgeron P Rustin D. Chretien et al. (1995) ArticleTitleMutation of a nuclear succinate dehydrogenase gene results in mitochondrial respiratory chain deficiency Nat Genet 11 IssueID2 144–9 Occurrence Handle10.1038/ng1095-144 Occurrence Handle1:CAS:528:DyaK2MXosF2rtr8%3D Occurrence Handle7550341

    Article  CAS  PubMed  Google Scholar 

  50. MA Birch-Machin RW Taylor B. Cochran et al. (2000) ArticleTitleoptic atrophy, ataxia, and myopathy associated with a mutation of a complex II gene Ann Neurol 48 IssueID3 330–5 Occurrence Handle1:CAS:528:DC%2BD3cXms1Ohsb0%3D Occurrence Handle10976639

    CAS  PubMed  Google Scholar 

  51. HC Au D Ream-Robinson LA. Bellew et al. (1995) ArticleTitleStructural organization of the gene encoding the human iron–sulfur subunit of succinate dehydrogenase Gene 159 IssueID2 249–53 Occurrence Handle1:CAS:528:DyaK2MXnt1Gqtbo%3D Occurrence Handle7622059

    CAS  PubMed  Google Scholar 

  52. D Astuti F Latif A. Dallol et al. (2001) ArticleTitleGene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial pheochromocytoma and to familial paraganglioma Am J Hum Genet 69 IssueID1 49–54 Occurrence Handle10.1086/321282 Occurrence Handle1:CAS:528:DC%2BD3MXls1emtrY%3D Occurrence Handle11404820

    Article  CAS  PubMed  Google Scholar 

  53. A Elbehti-Green HC Au JT. Mascarello et al. (1998) ArticleTitleCharacterization of the human SDHC gene encoding of the integral membrane proteins of succinate-quinone oxidoreductase in mitochondria Gene 213 IssueID1–2 133–40 Occurrence Handle1:CAS:528:DyaK1cXktlyqtr8%3D Occurrence Handle9714607

    CAS  PubMed  Google Scholar 

  54. S Niemann U Muller D Engelhardt P. Lohse (2003) ArticleTitleAutosomal dominant malignant and catecholamine-producing paraganglioma caused by a splice donor site mutation in SDHC Hum Genet 113 IssueID1 92–4 Occurrence Handle12658451

    PubMed  Google Scholar 

  55. H Hirawake M Taniwaki A. Tamura et al. (1999) ArticleTitleCharacterization of the human SDHD gene encoding the small subunit of cytochrome b (cybS) in mitochondrial succinate–ubiquinone oxidoreductase Biochim Biophys Acta 1412 IssueID3 295–300 Occurrence Handle1:CAS:528:DyaK1MXltV2hsb8%3D Occurrence Handle10482792

    CAS  PubMed  Google Scholar 

  56. O Gimm M Armanios H. Dziema et al. (2000) ArticleTitleand occult germ-line mutations in SDHD, a mitochondrial complex II gene, in nonfamilial pheochromocytoma Cancer Res 60 IssueID24 6822–5 Occurrence Handle1:CAS:528:DC%2BD3MXjsVKrsQ%3D%3D Occurrence Handle11156372

    CAS  PubMed  Google Scholar 

  57. HP Neumann B Bausch SR. McWhinney et al. (2002) ArticleTitleGerm-line mutations in nonsyndromic pheochromocytoma N Engl J Med 346 IssueID19 1459–66 Occurrence Handle10.1056/NEJMoa020152 Occurrence Handle1:CAS:528:DC%2BD38XjsVynsLc%3D Occurrence Handle12000816

    Article  CAS  PubMed  Google Scholar 

  58. AP Gimenez-Roqueplo J Favier P. Rustin et al. (2002) ArticleTitleConsequences of a SDHB Gene Mutation in an Apparently Sporadic Pheochromocytoma J Clin Endocrinol Metab 87 IssueID10 4771–4 Occurrence Handle10.1210/jc.2002-020525 Occurrence Handle1:CAS:528:DC%2BD38XnvFCrtr0%3D Occurrence Handle12364472

    Article  CAS  PubMed  Google Scholar 

  59. NS Chandel E Maltepe E. Goldwasser et al. (1998) ArticleTitlereactive oxygen species trigger hypoxia-induced transcription Proc Natl Acad Sci USA 95 IssueID20 11715–20 Occurrence Handle1:CAS:528:DyaK1cXmsV2hsro%3D Occurrence Handle9751731

    CAS  PubMed  Google Scholar 

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  1. Department of General, Visceral and Vascular Surgery, University of Halle, Halle, Germany, Ernst-Grube-Str, 40, 06097

    O. Gimm

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Gimm, O. Pheochromocytoma-associated syndromes: genes, proteins and functions of RET, VHL and SDHx. Familial Cancer 4, 17–23 (2005). https://doi.org/10.1007/s10689-004-5740-1

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