Ideas and Perspectives

Evolutionary Ecology

, Volume 25, Issue 1, pp 1-11

Linking genetic mechanisms of heterozygosity-fitness correlations to footprints of selection at single loci

  • Jakob C. MuellerAffiliated withDepartment of Behavioural Ecology and Evolutionary Genetics, Max-Planck Institute for Ornithology Email author 
  • , Joachim HermissonAffiliated withFaculty for Mathematics, University of Vienna
  • , Juanita Olano-MarinAffiliated withDepartment of Behavioural Ecology and Evolutionary Genetics, Max-Planck Institute for Ornithology
  • , Bengt HanssonAffiliated withSection of Animal Ecology, Department of Biology, Lund University
  • , Bart KempenaersAffiliated withDepartment of Behavioural Ecology and Evolutionary Genetics, Max-Planck Institute for Ornithology

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Abstract

Investigations of heterozygosity-fitness correlations (HFCs) are central to the understanding how genetic diversity is maintained in natural populations. Advanced genome-wide approaches will enrich the number of functional loci to be tested. We argue that a combined analysis of the genetic mechanisms of HFCs and selection signals at single loci will allow researchers to better understand the micro-evolutionary basis of HFCs. Different dominance relationships among the alleles at the locus can lead to positive, negative or null HFCs depending on the allele frequency distribution. These scenarios differ in the temporal stability of the HFCs and in the patterns of allele frequency changes over time. Here, we describe a simple theoretical framework that links the analyses of heterozygosity-fitness associations (ecological timescale) with tests for selection signals (evolutionary timescale). Different genomic footprints of selection can be expected for the different underlying genetic mechanisms of HFCs, and this information can be independently used for the classification of HFCs. We suggest that in addition to inbreeding and single-locus overdominant effects also loci under directional selection could play a significant role in the development of heterozygosity-fitness effects in large natural populations under recent or fluctuating ecological changes.

Keywords

Allelic dominance Recessiveness Microevolution Partial selective sweep Balancing selection Fluctuating selection