European Journal of Epidemiology

, Volume 26, Issue 7, pp 547–555

Parkinson’s disease risk from ambient exposure to pesticides

Authors

    • EpidemiologyUCLA School of Public Health
  • Sadie Costello
    • Environmental Health SciencesUC Berkeley School of Public Health
  • Myles Cockburn
    • Preventive Medicine and GeographyUSC/Keck School of Medicine
  • Xinbo Zhang
    • Preventive Medicine and GeographyUSC/Keck School of Medicine
  • Jeff Bronstein
    • Neurology, UCLA School of Medicine
  • Beate Ritz
    • Epidemiology, Environmental Health SciencesUCLA School of Public Health
    • NeurologyUCLA School of Medicine
NEURO-EPIDEMIOLOGY

DOI: 10.1007/s10654-011-9574-5

Cite this article as:
Wang, A., Costello, S., Cockburn, M. et al. Eur J Epidemiol (2011) 26: 547. doi:10.1007/s10654-011-9574-5

Abstract

Due to the heavy and expanding agricultural use of neurotoxic pesticides suspected to affect dopaminergic neurons, it is imperative to closely examine the role of pesticides in the development of Parkinson’s disease (PD). We focus our investigation on pesticide use in California’s heavily agricultural central valley by utilizing a unique pesticide use reporting system. From 2001 to 2007, we enrolled 362 incident PD cases and 341 controls living in the Central Valley of California. Employing our geographic information system model, we estimated ambient exposures to the pesticides ziram, maneb, and paraquat at work places and residences from 1974 to 1999. At workplaces, combined exposure to ziram, maneb, and paraquat increased risk of PD three-fold (OR: 3.09; 95% CI: 1.69, 5.64) and combined exposure to ziram and paraquat, excluding maneb exposure, was associated with a 80% increase in risk (OR:1.82; 95% CI: 1.03, 3.21). Risk estimates for ambient workplace exposure were greater than for exposures at residences and were especially high for younger onset PD patients and when exposed in both locations. Our study is the first to implicate ziram in PD etiology. Combined ambient exposure to ziram and paraquat as well as combined ambient exposure to maneb and paraquat at both workplaces and residences increased PD risk substantially. Those exposed to ziram, maneb, and paraquat together experienced the greatest increase in PD risk. Our results suggest that pesticides affecting different mechanisms that contribute to dopaminergic neuron death may act together to increase the risk of PD considerably.

Keywords

Case–control study Geographic information systems (GIS) Paraquat Parkinson’s disease Pesticide Ziram

Abbreviations

CA DPR

California department of pesticide regulation

CI

Confidence interval

GIS

Geographic information system

HIPAA

Health insurance portability and accountability act

OR

Odds ratio

PD

Parkinson’s disease

PLSS

Public land survey system

PUR

Pesticide use report

UCLA

University of California Los Angeles

UPS

Ubiquitin proteasome system

Copyright information

© Springer Science+Business Media B.V. 2011