Occupational exposures and risk of pancreatic cancer
First Online: 17 July 2010 Received: 31 March 2010 Accepted: 05 July 2010 DOI:
Cite this article as: Santibañez, M., Vioque, J., Alguacil, J. et al. Eur J Epidemiol (2010) 25: 721. doi:10.1007/s10654-010-9490-0 Abstract
The objective was to analyze the relationship between occupation (and specific occupational exposures) and risk of exocrine pancreatic cancer (EPC). We conducted a multicenter hospital-based case–control study in Eastern Spain. We included 161 incident cases of EPC (59.6% men, 94 with histological confirmation, of whom 80% had ductal adenocarcinoma). Cases were frequency-matched with 455 controls by sex, age and province of residence. Information was elicited using structured questionnaires. Occupations were coded according to the Spanish version of the International Standard Classification of Occupations 1988. Occupational exposure to a selection of carcinogenic substances was assessed with the Finnish Job-Exposure Matrix (FINJEM). Odds ratios (OR) and 95% confidence intervals (CI) were estimated by multiple logistic regression, adjusting for sex, age, province, education, alcohol and smoking. A higher risk of EPC was associated with having worked as ‘Miners, shotfirers, stone cutters and carvers’, ‘Machinery mechanics and fitters’, ‘Building trades workers’ and ‘Motor vehicle drivers’ in men, ‘Office Clerks’ in women, and ‘Waiters’ in both sexes. Cases with ductal adenocarcinomas were more likely to have been exposed to chlorinated hydrocarbon solvents (OR = 4.1, 95% CI: 1.1–15.2,
p-trend = 0.04). We also observed significant associations with exposure to ‘synthetic polymer dust exposure’ and ‘ionizing radiation’. Suggestive increases in risk were observed for ‘pesticides’, ‘diesel and gasoline engine exhaust’, and ‘hydrocarbon solvents’. Results support the hypothesis that occupational exposure to chlorinated hydrocarbon solvents is associated with exocrine pancreatic cancer. Keywords Chlorinated hydrocarbons Occupation Occupational exposures Pancreatic neoplasms Abbreviations CHC
Chlorinated hydrocarbon solvents
Exocrine pancreatic cancer
Finnish job-exposure matrix
Odds ratio for the highest level of exposure
Odds ratio restricted to men
Odds ratio restricted to women
Polycyclic aromatic hydrocarbons
Spanish national classification of occupations, 1994
This study is conducted for the PANESOES Study Group. Please see the Appendix section for the members of PANESOES Study Group.
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