European Journal of Epidemiology

, Volume 25, Issue 10, pp 721–730

Occupational exposures and risk of pancreatic cancer

Authors

  • Miguel Santibañez
    • Research Support UnitIFIMAV-Marques de Valdecilla Foundation
    • Departamento de Salud PúblicaUniversidad Miguel Hernández
  • Jesús Vioque
    • Departamento de Salud PúblicaUniversidad Miguel Hernández
    • CIBER de Epidemiología y Salud Pública (CIBERESP)
    • CIBER de Epidemiología y Salud Pública (CIBERESP)
    • Departamento de Biología Ambiental y Salud PúblicaUniversidad de Huelva
  • Manuela García de la Hera
    • Departamento de Salud PúblicaUniversidad Miguel Hernández
    • CIBER de Epidemiología y Salud Pública (CIBERESP)
  • Eduardo Moreno-Osset
    • Servicio de Medicina Digestiva, Hospital Universitario Dr. PesetUniversidad de Valencia
  • Alfredo Carrato
    • Servicio de Oncología MédicaHospital General de Elche
  • Miquel Porta
    • CIBER de Epidemiología y Salud Pública (CIBERESP)
    • Institut Municipal d’Investigació Mèdica (IMIM-Hospital del Mar)
    • Universitat Autònoma de Barcelona
  • Timo Kauppinen
    • Finnish Institute of Occupational Health (FIOH)
CANCER

DOI: 10.1007/s10654-010-9490-0

Cite this article as:
Santibañez, M., Vioque, J., Alguacil, J. et al. Eur J Epidemiol (2010) 25: 721. doi:10.1007/s10654-010-9490-0

Abstract

The objective was to analyze the relationship between occupation (and specific occupational exposures) and risk of exocrine pancreatic cancer (EPC). We conducted a multicenter hospital-based case–control study in Eastern Spain. We included 161 incident cases of EPC (59.6% men, 94 with histological confirmation, of whom 80% had ductal adenocarcinoma). Cases were frequency-matched with 455 controls by sex, age and province of residence. Information was elicited using structured questionnaires. Occupations were coded according to the Spanish version of the International Standard Classification of Occupations 1988. Occupational exposure to a selection of carcinogenic substances was assessed with the Finnish Job-Exposure Matrix (FINJEM). Odds ratios (OR) and 95% confidence intervals (CI) were estimated by multiple logistic regression, adjusting for sex, age, province, education, alcohol and smoking. A higher risk of EPC was associated with having worked as ‘Miners, shotfirers, stone cutters and carvers’, ‘Machinery mechanics and fitters’, ‘Building trades workers’ and ‘Motor vehicle drivers’ in men, ‘Office Clerks’ in women, and ‘Waiters’ in both sexes. Cases with ductal adenocarcinomas were more likely to have been exposed to chlorinated hydrocarbon solvents (OR = 4.1, 95% CI: 1.1–15.2, p-trend = 0.04). We also observed significant associations with exposure to ‘synthetic polymer dust exposure’ and ‘ionizing radiation’. Suggestive increases in risk were observed for ‘pesticides’, ‘diesel and gasoline engine exhaust’, and ‘hydrocarbon solvents’. Results support the hypothesis that occupational exposure to chlorinated hydrocarbon solvents is associated with exocrine pancreatic cancer.

Keywords

Chlorinated hydrocarbonsOccupationOccupational exposuresPancreatic neoplasms

Abbreviations

CHC

Chlorinated hydrocarbon solvents

CI

Confidence intervals

EPC

Exocrine pancreatic cancer

FINJEM

Finnish job-exposure matrix

OR

Odds ratio

ORh

Odds ratio for the highest level of exposure

OR men

Odds ratio restricted to men

OR women

Odds ratio restricted to women

PAH

Polycyclic aromatic hydrocarbons

CNO94

Spanish national classification of occupations, 1994

SD

Standard deviation

Copyright information

© Springer Science+Business Media B.V. 2010