European Journal of Epidemiology

, 23:459

The association of the metabolic syndrome with QTc interval in NHANES III


    • Department of Preventive medicineMenufiya University
  • Rachel P. Wildman
    • Department of Epidemiology and Population HealthAlbert Einstein College of Medicine
  • Jeanette Gustat
    • Department of EpidemiologyTulane School of Public Health & Tropical Medicine (SPHTM)
  • Janet Rice
    • Department of BiostatisticsTulane School of Public Health & Tropical Medicine (SPHTM)
  • Mohammed Y. Abdul Kareem
    • Department of Internal MedicineMenufiya University

DOI: 10.1007/s10654-008-9252-4

Cite this article as:
Faramawi, M.F., Wildman, R.P., Gustat, J. et al. Eur J Epidemiol (2008) 23: 459. doi:10.1007/s10654-008-9252-4


Purpose To examine the relationship of metabolic syndrome with corrected QT interval duration. Methods In a cross-sectional analysis of NHANES III, a representative sample of the adult US population, 3,495 individuals aged ≥40 years were categorized as having metabolic syndrome and not having metabolic syndrome as defined by ATP III. QT interval was measured from the standard 12-lead electrocardiogram. Results A weighted multi-linear regression analysis adjusted for age, gender, serum calcium, and potassium showed that metabolic syndrome was significantly associated with a corrected QT interval in milliseconds. The adjusted Beta coefficient and its corresponding standard error were (4.48 milliseconds, 0.95 milliseconds, P < 0.01). Conclusion These data indicate that metabolic syndrome is independently associated with a corrected QT interval duration. This study calls for careful ECG monitoring among persons with metabolic syndrome for early detection of a long corrected QT interval in order to prevent severe and often fatal arrhythmias.


Metabolic syndromeCross-sectional studiesElectrocardiography

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Copyright information

© Springer Science+Business Media B.V. 2008