Weight change, weight cycling and mortality in the ERFORT Male Cohort Study
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Objective To investigate the effect of weight change and weight fluctuations on all-cause-mortality in men. Methods Within a prospective population-based cohort of 1160 men aged 40–59 years at recruitment, complete weight change patterns from baseline and three follow-up examinations during a period of 15 years of follow-up was used to categorize the 505 men into stable obese, stable non-obese, weight gain, weight loss and weight fluctuation groups. For these men (age range: 55–74 years at start time of survival analysis) further survival was analyzed during the subsequent 15 years. Results Overall, 183 deaths were observed among the 505 men. Only weight fluctuations had a clear significant impact on all-cause mortality. Adjusted hazard rate ratio (HRR (95%-CI)) was 1.86 (1.31–2.66) after adjustment for age group, pre-existing cardiovascular disease or diabetes mellitus, smoking and socio-economic status. The risk rate due to weight loss was borderline significant (HRR = 1.81 (0.99–3.31)). Risk of death due to weight gain (HRR = 1.15 (0.70–1.88)) or stable obesity (HRR = 1.16 (0.69–1.94)), however, were not significantly increased compared to men staying non-obese for the first 15 years after cohort recruitment. Conclusion Weight fluctuations are a major risk factor for all-cause mortality in middle aged men. Moreover, stable obesity does not increase further mortality in men aged 55–74 years in long-term follow-up.
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- Weight change, weight cycling and mortality in the ERFORT Male Cohort Study
European Journal of Epidemiology
Volume 22, Issue 10 , pp 665-673
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- Cohort study
- Weight change
- Weight cycling
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- Author Affiliations
- 1. Institute of Epidemiology, GSF-National Research Center for Environment and Health, Ingolstaedter Landstrasse 1, 85764, Neuherberg, Germany
- 2. Institute of Medical Data Management, Biometrics and Epidemiology, Ludwig-Maximilians-University Munich, Munich, Germany
- 3. Central Hospital of Augsburg, MONICA/KORA Myocardial Infarction Registry, Augsburg, Germany
- 4. Department of Indoor Climatology, Institute of Occupational, Social and Environmental Medicine, Friedrich-Schiller-University Jena, Jena, Germany
- 5. Department for Preventive Cardiology, Medical School Erfurt, Erfurt, Germany