European Journal of Epidemiology

, Volume 22, Issue 10, pp 665–673

Weight change, weight cycling and mortality in the ERFORT Male Cohort Study

Authors

    • Institute of EpidemiologyGSF-National Research Center for Environment and Health
    • Institute of Medical Data Management, Biometrics and EpidemiologyLudwig-Maximilians-University Munich
  • Christa Meisinger
    • Institute of EpidemiologyGSF-National Research Center for Environment and Health
    • Central Hospital of AugsburgMONICA/KORA Myocardial Infarction Registry
  • Gabriele Woelke
    • Institute of EpidemiologyGSF-National Research Center for Environment and Health
  • Sabine Brasche
    • Department of Indoor Climatology, Institute of Occupational, Social and Environmental MedicineFriedrich-Schiller-University Jena
  • Gert Strube
    • Department for Preventive CardiologyMedical School Erfurt
  • Joachim Heinrich
    • Institute of EpidemiologyGSF-National Research Center for Environment and Health
Mortality

DOI: 10.1007/s10654-007-9167-5

Cite this article as:
Rzehak, P., Meisinger, C., Woelke, G. et al. Eur J Epidemiol (2007) 22: 665. doi:10.1007/s10654-007-9167-5

Abstract

Objective To investigate the effect of weight change and weight fluctuations on all-cause-mortality in men. Methods Within a prospective population-based cohort of 1160 men aged 40–59 years at recruitment, complete weight change patterns from baseline and three follow-up examinations during a period of 15 years of follow-up was used to categorize the 505 men into stable obese, stable non-obese, weight gain, weight loss and weight fluctuation groups. For these men (age range: 55–74 years at start time of survival analysis) further survival was analyzed during the subsequent 15 years. Results Overall, 183 deaths were observed among the 505 men. Only weight fluctuations had a clear significant impact on all-cause mortality. Adjusted hazard rate ratio (HRR (95%-CI)) was 1.86 (1.31–2.66) after adjustment for age group, pre-existing cardiovascular disease or diabetes mellitus, smoking and socio-economic status. The risk rate due to weight loss was borderline significant (HRR = 1.81 (0.99–3.31)). Risk of death due to weight gain (HRR = 1.15 (0.70–1.88)) or stable obesity (HRR = 1.16 (0.69–1.94)), however, were not significantly increased compared to men staying non-obese for the first 15 years after cohort recruitment. Conclusion Weight fluctuations are a major risk factor for all-cause mortality in middle aged men. Moreover, stable obesity does not increase further mortality in men aged 55–74 years in long-term follow-up.

Keywords

Gender Cohort study Mortality Obesity Weight change Weight cycling

Abbreviations

BMI

Body mass index

ERFORT study

Erfurt Male Cohort Study

HRR

Hazard rate ratio

95%-CI

95%-Confidence interval

Copyright information

© Springer Science+Business Media B.V. 2007