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Aripiprazole-induced chorioretinopathy: multimodal imaging and electrophysiological features

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Abstract

Purpose

To report the first documented case of aripiprazole-induced chorioretinopathy.

Methods and results

A 47-year-old schizophrenic patient with loss of vision due to an atypical retinopathy was investigated. She had been treated with aripiprazole for 8 years. Multimodal imaging showed in the right eye a large area of retinal atrophy predominating in the outer retina, including the posterior pole up to the upper temporal periphery, and in the left eye a serous retinal detachment. The electroretinogram exhibited decreased and delayed responses of both the rod and cone systems; the electrooculogram showed no light peak.

Conclusion

Aripiprazole, an atypical antipsychotic, was introduced more recently than the antipsychotics commonly incriminated in chorioretinopathies, such as thioridazine. Optical coherence tomography was not used to document former cases of antipsychotic-related chorioretinopathies. Although pathophysiological mechanisms are poorly understood, imaging of the present case points toward an involvement of the retinal pigmentary epithelium. Clinicians should be aware of the potential chorioretinal toxicity of new atypical antipsychotics.

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Acknowledgments

To Dr. Philippe REMY, MD, for the psychiatric follow-up of the patient; to Dr. Jihad KREIDIE, MD, for having referred the patient; to Mrs. Maryse FALUE, orthoptist, for her help in the electrophysiological recordings; to Dr. Céline VERSTUYET, PharmD, Ph.D, for the pharmacogenetic testings; to Mrs. Claudine RINALDI, Aline ANTONIO and Claire FRANCHISSEUR for the coordination of genetic screening, DNA collection and BEST1 Sanger sequencing.

Conflict of interest

None.

Author information

Authors and Affiliations

  1. Ophtalmologie, Hôpital Privé Saint Martin, 18 rue des Roquemonts, 14000, Caen, France

    Céline Faure

  2. U968, INSERM, 75012, Paris, France

    Isabelle Audo & Christina Zeitz

  3. UMR_S 968, Institut de la Vision, UPMC Univ Paris 06, 75012, Paris, France

    Isabelle Audo & Christina Zeitz

  4. UMR_7210, CNRS, 75012, Paris, France

    Isabelle Audo & Christina Zeitz

  5. Centre Hospitalier National d’Ophtalmologie des Quinze-Vingts, DHU ViewMaintain, INSERM-DHOS CIC 1423, 75012, Paris, France

    Isabelle Audo

  6. Ophtalmologie, CHU de Caen, Avenue de la Côte de Nacre, 14000, Caen, France

    Jean-Bernard Letessier

  7. Ophtalmologie, Hôpital Universitaire Necker-Enfants Malades, 149 rue de Sèvres, 75015, Paris, France

    Matthieu P. Robert

  8. COGNAC-G, UMR 8257, CNRS–IRBA-Université Paris Descartes, Sorbonne Paris Cité, Paris, France

    Matthieu P. Robert

Authors
  1. Céline Faure
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  2. Isabelle Audo
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  3. Christina Zeitz
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  4. Jean-Bernard Letessier
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  5. Matthieu P. Robert
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Corresponding author

Correspondence to Céline Faure.

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Faure, C., Audo, I., Zeitz, C. et al. Aripiprazole-induced chorioretinopathy: multimodal imaging and electrophysiological features. Doc Ophthalmol 131, 35–41 (2015). https://doi.org/10.1007/s10633-015-9494-x

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  • DOI: https://doi.org/10.1007/s10633-015-9494-x

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