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Changes of HBV DNA After Chemoembolization for Hepatocellular Carcinoma and the Efficacy of Antiviral Treatment

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Abstract

Unlike systemic chemotherapy for hematological malignancies with hepatitis B virus (HBV) infection, transarterial chemoembolization (TACE) for HBV-related hepatocellular carcinoma (HCC) has only recently been reported to cause HBV reactivation and subsequent hepatitis. Most patients with HBV-related HCC have an underlying disease with liver fibrosis or cirrhosis, and TACE may potentially induce HBV reactivation and liver decompensation. Currently, there are no clinical guidelines for managing TACE-caused HBV reactivation. In this review, we summarize the changes of HBV status and liver function after TACE and the effect of antiviral treatment before, during, or after TACE.

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  1. Department of Hepatobiliary Oncology, Sun Yat-sen University Cancer Center, 651, Dongfeng Road East, Guangzhou, 510060, Guangdong, People’s Republic of China

    Xiao-Jun Lin, Xiang-Ming Lao, Ming Shi & Sheng-Ping Li

  2. State Key Laboratory of Southern China, Guangzhou, 510060, Guangdong, People’s Republic of China

    Xiao-Jun Lin, Xiang-Ming Lao, Ming Shi & Sheng-Ping Li

  3. Collaborative Innovation Center for Cancer Medicine, Guangzhou, 510060, Guangdong, People’s Republic of China

    Xiao-Jun Lin, Xiang-Ming Lao, Ming Shi & Sheng-Ping Li

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Lin, XJ., Lao, XM., Shi, M. et al. Changes of HBV DNA After Chemoembolization for Hepatocellular Carcinoma and the Efficacy of Antiviral Treatment. Dig Dis Sci 61, 2465–2476 (2016). https://doi.org/10.1007/s10620-016-4167-5

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