Donor-Transmitted Malignancy in a Liver Transplant Recipient: A Case Report and Review of Literature
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Donor-transmitted malignancy is a rare complication of organ transplantation. This case illustrates a donor-transmitted adenocarcinoma in a patient 11 months after an orthotopic liver transplant for cryptogenic cirrhosis and hepatocellular carcinoma (HCC). Diagnosis of donor-transmitted malignancy may be challenging and can be confused with HCC recurrence. A timely diagnosis is crucial as a delay may limit treatment options. Biopsy of newly found liver lesions and the use of karyotypic and microsatellite analysis may be essential for diagnosis. Protocols should be in place to help recognize and limit the incidence of donor-transmitted malignancy.
- McPhaul JJ, McIntosh DA. Tissue transplantation still vexes. N Engl Med. 1965;272:105.
- Kauffman HM, McBride MA, Cherikh WS, Spain PC, Marks WH, Roza AM. Transplant tumor registry: donor related malignancies. Transplantation. 2002;74:358–362. CrossRef
- Mazzaferro V, Regalia E, Doci R, et al. Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis. N Engl Med. 1996;334:693–699. CrossRef
- Donovan JA, Simmons FA, Esrason KT, et al. Donor origin of a post-transplant liver allograft malignancy identified by fluorescence in situ hybridization for the Y chromosome and DNA genotyping. Transplantation. 1997;63:80–84. CrossRef
- Pfeiffer H, Ortmann C, Klein A, Brinkmann B. Origin of hepatocellular carcinoma recurring after allotransplantation revealed by microsatellite analysis. J Clin Pathol. 1997;50:792–794. CrossRef
- Ng IOL, Shek TWH, Thung SN, et al. Microsatellite analysis in post-tranplantation lymphoproliferative disorder to determine donor/recipient origin. Mod Pathol. 2000;13:1180–1185. CrossRef
- Kakar S, Burgart LJ, Charlton MR, Saito Y, Halling K, Thibodeau SN. Origin of adenocarcinoma in a transplanted liver determined by microsatelliteanalysis. Hum Pathol. 2002;33:435–436. CrossRef
- Ison MG, Nalesnik MA. An update on donor-derived disease transmission in organ transplantation. Am J Transplant. 2011;11:1123–1130. CrossRef
- Detry O, Honore P, Jacquet N. Management of recipients of hepatic allografts harvested from donors with malignancy diagnosed shortly after transplantation. Clin Tranplant. 1998;12:579–581.
- Florman S, Bowne W, Kim-Schluger L, et al. Unresectable squamous cell carcinoma of donor origin treated with immunosuppression withdrawal and liver transplantation. Am J Transplant. 2003;4:278–282. CrossRef
- Gray BN, Anderson JE, Burton MA, et al. Regression of liver metastases following treatment with yttrium-90 microspheres. Aust NZ J Surg. 1992;62:105–110.
- Birkeland SA, Storm HH. Risk for tumor and other disease transmission by transplantation: a population-based study of unrecognized malignancies and other diseases in organ donors. Transplantation. 2002;74:1409–1413. CrossRef
- Buell JF, Beebe TM, Trofe J, et al. Donor transmitted malignancies. Ann Transplant. 2004;9:53–56.
- Nalesnik MA, Woodle ES, DiMaio JM, et al. Donor-transmitted malignancies in organ transplantation: assessment of clinical risk. Am J Transplant. 2011;11:1140–1147. CrossRef
- Lipschutz GS, Baxter-Lowe LA, Nguyen T, Jones KD, Ascher NL, Feng S. Death from donor-transmitted malignancy despite emergency liver transplantation. Liver Transplant. 2003;9:1102–1107. CrossRef
- Fiorentino M, D’Errico A, Corti B, et al. A multiorgan donor cancer screening protocol: the Italian Emilia–Romagna region experience. Transplantation. 2003;76:1695–1699. CrossRef
- Zucchini N, Fiorentino M, Grigioni AD, et al. The Italian multiorgan donor cancer screening protocol: 2002–2005 experience. Transplantation. 2008;85:S57–S60. CrossRef
- Organ Procurement and Transplantation Network (OPTN) and Scientific Registry of Transplant Recipients (SRTR). OPTN/SRTR 2010 Annual Data Report. Rockville, MD: Department of Health and Human Services, Health Resources and Services Administration, Healthcare Systems Bureau, Division of Transplantation; 2011.
- Donor-Transmitted Malignancy in a Liver Transplant Recipient: A Case Report and Review of Literature
Digestive Diseases and Sciences
Volume 58, Issue 5 , pp 1185-1190
- Cover Date
- Print ISSN
- Online ISSN
- Springer US
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- Liver transplant
- Donor-transmitted malignancy
- Microsatellite analysis
- Hepatocellular carcinoma
- Industry Sectors
- Author Affiliations
- 1. Division of Gastroenterology and Hepatology, Section of Transplant Hepatology, School of Medicine, Johns Hopkins University, 600 N. Wolfe Street, Blalock 459, Baltimore, MD, 21287, USA
- 2. Section of Liver Transplant Surgery, School of Medicine, Johns Hopkins University, 720 Rutland Avenue, Ross 771, Baltimore, MD, 21205, USA
- 3. Department of Pathology, School of Medicine, Johns Hopkins University, 600 N. Wolfe Street, Park SB 202, Baltimore, MD, 21287, USA
- 4. Department of Radiology, School of Medicine, Johns Hopkins University, 600 N. Wolfe Street, MRI 143, Baltimore, MD, 21287, USA
- 5. Division of Gastroenterology and Hepatology, Section of Transplant Hepatology, School of Medicine, Johns Hopkins University, 1830 E. Monument, Room 429, Baltimore, MD, 21205, USA