Digestive Diseases and Sciences

, Volume 58, Issue 5, pp 1185–1190

Donor-Transmitted Malignancy in a Liver Transplant Recipient: A Case Report and Review of Literature

  • Brian Kim
  • Tinsay Woreta
  • Po-Hung Chen
  • Berkeley Limketkai
  • Andrew Singer
  • Nabil Dagher
  • Andrew Cameron
  • Ming-Tseh Lin
  • Ihab Kamel
  • Ahmet Gurakar
Review

DOI: 10.1007/s10620-012-2501-0

Cite this article as:
Kim, B., Woreta, T., Chen, PH. et al. Dig Dis Sci (2013) 58: 1185. doi:10.1007/s10620-012-2501-0

Abstract

Donor-transmitted malignancy is a rare complication of organ transplantation. This case illustrates a donor-transmitted adenocarcinoma in a patient 11 months after an orthotopic liver transplant for cryptogenic cirrhosis and hepatocellular carcinoma (HCC). Diagnosis of donor-transmitted malignancy may be challenging and can be confused with HCC recurrence. A timely diagnosis is crucial as a delay may limit treatment options. Biopsy of newly found liver lesions and the use of karyotypic and microsatellite analysis may be essential for diagnosis. Protocols should be in place to help recognize and limit the incidence of donor-transmitted malignancy.

Keywords

Liver transplantDonor-transmitted malignancyMicrosatellite analysisHepatocellular carcinoma

Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  • Brian Kim
    • 1
  • Tinsay Woreta
    • 1
  • Po-Hung Chen
    • 1
  • Berkeley Limketkai
    • 1
  • Andrew Singer
    • 2
  • Nabil Dagher
    • 2
  • Andrew Cameron
    • 2
  • Ming-Tseh Lin
    • 3
  • Ihab Kamel
    • 4
  • Ahmet Gurakar
    • 5
  1. 1.Division of Gastroenterology and Hepatology, Section of Transplant Hepatology, School of MedicineJohns Hopkins UniversityBaltimoreUSA
  2. 2.Section of Liver Transplant Surgery, School of MedicineJohns Hopkins UniversityBaltimoreUSA
  3. 3.Department of Pathology, School of MedicineJohns Hopkins UniversityBaltimoreUSA
  4. 4.Department of Radiology, School of MedicineJohns Hopkins UniversityBaltimoreUSA
  5. 5.Division of Gastroenterology and Hepatology, Section of Transplant Hepatology, School of MedicineJohns Hopkins UniversityBaltimoreUSA