Donor-Transmitted Malignancy in a Liver Transplant Recipient: A Case Report and Review of Literature
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Donor-transmitted malignancy is a rare complication of organ transplantation. This case illustrates a donor-transmitted adenocarcinoma in a patient 11 months after an orthotopic liver transplant for cryptogenic cirrhosis and hepatocellular carcinoma (HCC). Diagnosis of donor-transmitted malignancy may be challenging and can be confused with HCC recurrence. A timely diagnosis is crucial as a delay may limit treatment options. Biopsy of newly found liver lesions and the use of karyotypic and microsatellite analysis may be essential for diagnosis. Protocols should be in place to help recognize and limit the incidence of donor-transmitted malignancy.
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- Donor-Transmitted Malignancy in a Liver Transplant Recipient: A Case Report and Review of Literature
Digestive Diseases and Sciences
Volume 58, Issue 5 , pp 1185-1190
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- Liver transplant
- Donor-transmitted malignancy
- Microsatellite analysis
- Hepatocellular carcinoma
- Industry Sectors
- Author Affiliations
- 1. Division of Gastroenterology and Hepatology, Section of Transplant Hepatology, School of Medicine, Johns Hopkins University, 600 N. Wolfe Street, Blalock 459, Baltimore, MD, 21287, USA
- 2. Section of Liver Transplant Surgery, School of Medicine, Johns Hopkins University, 720 Rutland Avenue, Ross 771, Baltimore, MD, 21205, USA
- 3. Department of Pathology, School of Medicine, Johns Hopkins University, 600 N. Wolfe Street, Park SB 202, Baltimore, MD, 21287, USA
- 4. Department of Radiology, School of Medicine, Johns Hopkins University, 600 N. Wolfe Street, MRI 143, Baltimore, MD, 21287, USA
- 5. Division of Gastroenterology and Hepatology, Section of Transplant Hepatology, School of Medicine, Johns Hopkins University, 1830 E. Monument, Room 429, Baltimore, MD, 21205, USA