Review

Digestive Diseases and Sciences

, Volume 58, Issue 5, pp 1185-1190

Donor-Transmitted Malignancy in a Liver Transplant Recipient: A Case Report and Review of Literature

  • Brian KimAffiliated withDivision of Gastroenterology and Hepatology, Section of Transplant Hepatology, School of Medicine, Johns Hopkins University Email author 
  • , Tinsay WoretaAffiliated withDivision of Gastroenterology and Hepatology, Section of Transplant Hepatology, School of Medicine, Johns Hopkins University
  • , Po-Hung ChenAffiliated withDivision of Gastroenterology and Hepatology, Section of Transplant Hepatology, School of Medicine, Johns Hopkins University
  • , Berkeley LimketkaiAffiliated withDivision of Gastroenterology and Hepatology, Section of Transplant Hepatology, School of Medicine, Johns Hopkins University
  • , Andrew SingerAffiliated withSection of Liver Transplant Surgery, School of Medicine, Johns Hopkins University
  • , Nabil DagherAffiliated withSection of Liver Transplant Surgery, School of Medicine, Johns Hopkins University
  • , Andrew CameronAffiliated withSection of Liver Transplant Surgery, School of Medicine, Johns Hopkins University
  • , Ming-Tseh LinAffiliated withDepartment of Pathology, School of Medicine, Johns Hopkins University
  • , Ihab KamelAffiliated withDepartment of Radiology, School of Medicine, Johns Hopkins University
    • , Ahmet GurakarAffiliated withDivision of Gastroenterology and Hepatology, Section of Transplant Hepatology, School of Medicine, Johns Hopkins University

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Abstract

Donor-transmitted malignancy is a rare complication of organ transplantation. This case illustrates a donor-transmitted adenocarcinoma in a patient 11 months after an orthotopic liver transplant for cryptogenic cirrhosis and hepatocellular carcinoma (HCC). Diagnosis of donor-transmitted malignancy may be challenging and can be confused with HCC recurrence. A timely diagnosis is crucial as a delay may limit treatment options. Biopsy of newly found liver lesions and the use of karyotypic and microsatellite analysis may be essential for diagnosis. Protocols should be in place to help recognize and limit the incidence of donor-transmitted malignancy.

Keywords

Liver transplant Donor-transmitted malignancy Microsatellite analysis Hepatocellular carcinoma